本文關(guān)鍵詞： 腎移植術(shù) 肺炎 血必凈注射液　出處：《福建中醫(yī)藥大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:采用血必凈注射液聯(lián)合常規(guī)治療治療腎移植術(shù)后肺炎屬痰熱挾瘀阻肺證者,與常規(guī)治療組對(duì)比,觀察2組治療前后相關(guān)炎癥指標(biāo)、細(xì)胞免疫、凝血功能、腎功能、生活質(zhì)量的變化情況,探討血必凈注射液對(duì)腎移植術(shù)后肺炎患者的輔助治療作用。方法:收集2015年7月-2017年1月在南京軍區(qū)福州總醫(yī)院呼吸與危重癥醫(yī)學(xué)科、干細(xì)胞治療科、泌尿外科三科住院部符合腎移植術(shù)后肺炎納入標(biāo)準(zhǔn)的患者42例,依據(jù)隨機(jī)數(shù)字表將其分為對(duì)照組22例,試驗(yàn)組20例。兩組均予以包括抗感染、控制性氧療、解痙、化痰、平喘等在內(nèi)的常規(guī)治療,試驗(yàn)組在常規(guī)治療的基礎(chǔ)上加用血必凈注射液(天津紅日藥業(yè)股份有限公司)50ml+NS 100ml靜滴2/日,療程為7天。兩組病人均于治療前(D0)、治療第3日(D3)、治療第7日(D7)檢測(cè)外周血白細(xì)胞計(jì)數(shù)(WBC)、中性粒細(xì)胞比率(NE%)、淋巴細(xì)胞計(jì)數(shù)(LY)、降鈣素原(PCT)、C反應(yīng)蛋白(CRP)、D-二聚體、血小板計(jì)數(shù)(PLT)、纖維蛋白原(Fib)、活化部分凝血酶原時(shí)間(APTT)、凝血酶原時(shí)間(PT)、血肌酐(SCR)、尿素氮(BUN)及行APACHEⅡ評(píng)分,于D0及D7檢測(cè)外周血CD3、CD4、CD8、CD4/CD8。所有數(shù)據(jù)均應(yīng)用統(tǒng)計(jì)學(xué)軟件SPSS20.0進(jìn)行統(tǒng)計(jì)分析。結(jié)果:1.兩組病人治療前一般資料、WBC、NE%、LY、PCT、CRP、D-二聚體、PLT、Fib、APTT、PT、SCR、BUN、CD3、CD4、CD8、CD4/CD8、APACHEⅡ評(píng)分差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。2.D3 試驗(yàn)組 WBC、NE%、PCT、CRP、SCR、BUN、D-二聚體、APACHEⅡ評(píng)分較前有所下降,差異具有統(tǒng)計(jì)學(xué)意義(P0.05);對(duì)照組WBC、NE%、PCT、CRP、BUN、D-二聚體、APACHEⅡ評(píng)分較前有所下降,差異具有統(tǒng)計(jì)學(xué)意義(P0.05);試驗(yàn)組與對(duì)照組相對(duì)比,PCT、CRP下降更明顯,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。D7兩組 WBC、NE%、PCT、CRP、SCR、BUN、D-二聚體、APACHEⅡ評(píng)分較前有所下降,差異具有統(tǒng)計(jì)學(xué)意義(P0.05);試驗(yàn)組與對(duì)照組相對(duì)比,PCT、CRP、SCR、BUN、D-二聚體、APACHEⅡ評(píng)分下降更明顯,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組治療前后 LY、PLT、Fib、APTT、PT、CD3、CD4、CD8、CD4/CD8 差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。3.無(wú)論D3日或D7日,試驗(yàn)組總體療效優(yōu)于對(duì)照組(P0.05)。結(jié)論:1.血必凈注射液能有效改善腎移植術(shù)后肺炎屬痰熱挾瘀阻肺證患者的臨床癥狀,減輕炎癥反應(yīng)。2.血必凈注射液對(duì)腎移植術(shù)后肺炎屬痰熱挾瘀阻肺證患者可改善凝血功能異常。3.血必凈注射液對(duì)腎移植術(shù)后肺炎屬痰熱挾瘀阻肺證患者可改善腎功能異常。4.血必凈注射液對(duì)于增強(qiáng)腎移植術(shù)后肺炎屬痰熱挾瘀阻肺證患者的細(xì)胞免疫功能方面療效尚未明確,有待進(jìn)一步研究。
[Abstract]:Objective: to use Xuebijing injection combined with routine therapy to treat pneumonia after renal transplantation which belongs to phlegm-heat combined with stagnation of lung syndrome. Compared with the routine treatment group, the inflammatory indexes, cellular immunity and coagulation function were observed before and after treatment in two groups. Changes of renal function and quality of life. Objective: to investigate the effect of Xuebijing injection on the treatment of pneumonia patients after renal transplantation. Methods: from July 2015 to January 2017, collected from the Department of Respiratory and critical Medicine of Fuzhou General Hospital of Nanjing military region. Forty-two patients who met the admission criteria of pneumonia after renal transplantation were divided into control group (n = 22) according to random digital table. There were 20 cases in the experimental group. Both groups were given routine treatment including anti-infection, controlled oxygen therapy, spasmolysis, phlegm reduction, asthma relief and so on. The experimental group was treated with Xuebijing injection on the basis of routine therapy (Tianjin Hongri Pharmaceutical Co., Ltd.) 50ml NS 100ml intravenous drip 2 days. The course of treatment was 7 days. The patients in both groups were treated with D0 and D3 on 3rd and D7 on 7th respectively. The white blood cell count and neutrophil ratio were detected by WBC and neutrophil ratio (neutrophil ratio, neutrophil ratio, neutrophil ratio, neutrophil ratio, neutrophil ratio). Lymphocyte count, procalcitonin (PCT) C-reactive protein (CRP), platelet count (PLT), fibrinogen (Fib). Activated partial prothrombin time (APTTT), prothrombin time (PTT), serum creatinine (SCR), bun (bun) and APACHE 鈪，

本文編號(hào)：1489784