發(fā)布時(shí)間：2018-01-23 11:34

  本文關(guān)鍵詞： 用力肺活量 一秒量 一秒率 肺功能非特異改變 限制性通氣功能障礙　出處：《山東大學(xué)》2014年碩士論文　論文類(lèi)型：學(xué)位論文

【摘要】：研究目的： 分析肺功能非特異改變的肺功能參數(shù)特點(diǎn),探討其臨床意義。 研究方法： 采用回顧性隊(duì)列研究的方法,調(diào)取山東大學(xué)齊魯醫(yī)院2013.8.1至2014.2.1期間歸檔的肺功能檢查報(bào)告單5259例。納入標(biāo)準(zhǔn)：①用力肺活量(FVC)及第一秒用力呼氣容積(FEV,)下降；②第一秒用力呼氣容積占用力肺活量比值(FEV1/FVC)正常；共304例。繼之,從中選擇具有一氧化碳彌散法或體積描計(jì)儀法肺總量(TLC)數(shù)據(jù)者,共65例。最后,根據(jù)受試者TLC正常或降低,分為肺功能非特異改變組(TLC正常,n=20)20例和限制性通氣功能障礙組(TLC下降,n=45)45例兩組。應(yīng)用SPSS19.0軟件,進(jìn)行兩樣本t檢驗(yàn),比較肺功能非特異組和限制性通氣功能障礙組,性別、年齡、體重指數(shù)(BMI)、吸煙史以及與肺功能參數(shù)特點(diǎn)；分析肺功能非特異改變組中包含的疾病種類(lèi)。 研究結(jié)果 1.肺功能結(jié)果表現(xiàn)為FVC及FEV1下降,FEV1/FVC正�；蛏叩氖茉囌吖�304例,占所有肺功能受試者的5.7%,其中65例進(jìn)行TLC的測(cè)定。 2.肺功能非特異改變組和限制性通氣功能障礙組相比,年齡、性別、吸煙史及BMI無(wú)統(tǒng)計(jì)學(xué)差異。與限制性通氣功能障礙組相比,肺功能非特異改變組的肺活量占預(yù)計(jì)值百分比(VC%pred)、用力肺活量占預(yù)計(jì)值百分比(FVC%pred),第一秒用力呼氣容積占預(yù)計(jì)值的百分比(FEV,%pred)、殘氣量占預(yù)計(jì)值百分比(RV%pred)、肺總量占預(yù)計(jì)值百分比(TLC%pred)、殘總比(RV/TLC)較高,均有統(tǒng)計(jì)學(xué)差異(P0.05)。肺功能非特異改變組的最顯著特點(diǎn)為殘氣量(RV)及RV/TLC增加,其中有56.5%的受試者表現(xiàn)為RV升高,78.3%的受試者表現(xiàn)為RV/TLC升高。 3.肺功能非特異改變組的臨床診斷包括支氣管哮喘10例；慢性支氣管炎3例；支氣管擴(kuò)張癥2例；間質(zhì)性肺疾病2例；脊髓側(cè)索硬化癥1例；診斷不明確2例。最常見(jiàn)的疾病為支氣管哮喘。 結(jié)論： 1.表現(xiàn)為FVC及FEV1下降,FEV1/FVC正常的肺功能結(jié)果類(lèi)型并不少見(jiàn),臨床醫(yī)生應(yīng)提起關(guān)注。 2.導(dǎo)致肺功能的非特異改變的疾病主體,既包括阻塞性疾病也包括限制性疾病。最常見(jiàn)的疾病為支氣管哮喘。 3.肺功能結(jié)果表現(xiàn)為FVC及FEV1下降,FEV1/FVC正常時(shí),需進(jìn)一步測(cè)定TLC。
[Abstract]:Objectives of the study: To analyze the characteristics of pulmonary function parameters in non-specific changes of lung function and to explore its clinical significance. Research methods: Retrospective cohort study was used. 5259 cases of lung function examination report filed in Qilu Hospital, Shandong University from 8.1 to 2014.2.1. FVC was included in the standard of forced vital capacity (FVC). Forced expiratory volume and FEV at 1 second. ) decline; 2the ratio of forced expiratory volume occupancy and FEV1 / FVCwas normal at 1 second; A total of 304 cases were followed by 65 patients who had carbon monoxide dispersion or volumetric instrument data. Finally, the TLC was normal or decreased according to the subjects. The patients were divided into two groups: 20 patients with normal TLC and 45 patients with restrictive ventilation dysfunction. SPSS19.0 software was used. Two t-test samples were performed to compare the characteristics of lung function nonspecific group and restrictive ventilation dysfunction group, sex, age, body mass index (BMI), smoking history and pulmonary function parameters. The types of diseases included in non-specific changes in lung function were analyzed. Research results 1. There were 304 subjects with normal or elevated FEV1 / FVC in FVC and FEV1, accounting for 5.7% of all pulmonary functional subjects. TLC was measured in 65 cases. 2. There were no significant differences in age, sex, smoking history and BMI between non-specific pulmonary function change group and restrictive ventilation dysfunction group. The vital capacity of the patients with nonspecific changes in lung function was as a percentage of the predicted value, and the forced vital capacity as a percentage of the predicted value was higher than that of the control group (FVCpredd). 1 second forced expiratory volume as a percentage of expected value FEV predder, residual volume as percentage of predicted value RV predd, total lung volume as percentage of predicted value TLCpred). The residual total was higher than that of RV / TLC, and there was statistical difference (P 0.05). The most significant feature of non-specific changes in lung function was the increase of residual volume (RV) and RV/TLC. 56.5% of the subjects showed elevated RV and 78. 3% showed elevated RV/TLC. 3. 10 cases of bronchial asthma were included in the clinical diagnosis of nonspecific changes in lung function. 3 cases of chronic bronchitis; Bronchiectasis 2 cases; 2 cases of interstitial pulmonary disease; 1 case of lateral sclerosis of spinal cord; The diagnosis was unclear in 2 cases. The most common disease was bronchial asthma. Conclusion: 1. The type of normal pulmonary function with FVC and FEV1 decreased and FEV1 / FVC is not uncommon. Clinicians should pay attention to it. 2. The main body of disease that causes nonspecific changes in lung function, both obstructive and restrictive. The most common disease is bronchial asthma. 3. The results of pulmonary function showed that FVC and FEV1 decreased and FEV 1 / FVC was normal, TLC should be measured further.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R56

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

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本文編號(hào)：1457443