本文關(guān)鍵詞：肉芽腫性肺疾病的臨床診治現(xiàn)狀　出處：《吉林大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 肉芽腫性肺疾病 肺結(jié)核 結(jié)節(jié)病 韋格納肉芽腫 Churg-Strauss綜合征

【摘要】：背景:肉芽腫性肺疾病(Granulomatous Lung Disease,GLD)或稱肺肉芽腫病(1ung granulomatosis),是一組病因不同但均以肉芽腫形成為共同病理特征的肺部疾病的總稱。肉芽腫性肺疾病在臨床上較常見,包括臨床上發(fā)病率較高的肺結(jié)核(pulmonary tuberculosis,TB)和結(jié)節(jié)病等,也包括臨床少見的韋格納肉芽腫(Wegener’s granulomatosis,WG,也稱肉芽腫性多血管炎,granulomatosis with polyangiitis,GPA)、Churg-Strauss綜合征(Churg-Stauss Syndrome,CSS,也稱變應(yīng)性肉芽腫性血管炎,allergic granulomatous angiitis,AGA,也稱嗜酸性肉芽腫性多血管炎,eosinophilic granulomatosis with polyangiitis,EGPA)以及多種罕見疾病。各種疾病的病因不同,在流行病學(xué)、臨床表現(xiàn)、影像學(xué)表現(xiàn)、實驗室檢查等方面具有不同的特點,在治療方法上也存在很大差別。目的:探討肉芽腫性肺疾病的臨床特點,歸納其現(xiàn)有的診斷和治療方法,以利于提高對肉芽腫性肺疾病的認(rèn)識及診療水平。方法:通過檢索Pub Med、CNKI、萬方數(shù)據(jù)庫等,搜集篩選相關(guān)中英文文獻(xiàn),總結(jié)肉芽腫性肺疾病的病因和發(fā)病機(jī)制以及肺結(jié)核、結(jié)節(jié)病、韋格納肉芽腫、Churg-Strauss綜合征等四種疾病的流行病學(xué)、臨床表現(xiàn)、診斷、治療等各方面的研究現(xiàn)狀,將對臨床工作有指導(dǎo)意義的內(nèi)容予以歸納,并總結(jié)肺結(jié)核與結(jié)節(jié)病、韋格納肉芽腫與Churg-Strauss綜合征鑒別診斷的要點。結(jié)論:肉芽腫性肺疾病根據(jù)肉芽腫形成的病因,可分為感染性和非感染性兩類。非感染性肉芽腫性肺疾病包括多種病因尚未明確的疾病,國內(nèi)外文獻(xiàn)認(rèn)為遺傳、環(huán)境、免疫、感染等多種因素參與其發(fā)病,但尚無統(tǒng)一共識。肉芽腫的形成是各種肉芽腫性肺疾病共同的病理學(xué)特征,而各種類型又具有各自的特點,常是診斷和鑒別診斷的關(guān)鍵證據(jù)。這些疾病在流行病學(xué)、臨床表現(xiàn)、影像學(xué)表現(xiàn)、實驗室檢查等方面具有一定的特點,可以為臨床診斷提供線索,但尚缺乏特異性和敏感性均較高的診斷手段。感染性肉芽腫性肺疾病的治療主要是有效的抗感染和對癥支持治療。結(jié)節(jié)病、韋格納肉芽腫、Churg-Strauss綜合征等非感染性肉芽腫性肺疾病的治療主要是糖皮質(zhì)激素和免疫抑制劑,手段單一,療程長,長期應(yīng)用不良反應(yīng)多,而且用量和減量速度不當(dāng)可能會造成病情反復(fù)。肉芽腫性肺疾病的預(yù)后與早期有效的治療密切相關(guān)。此外,某些類型與疾病累及臟器、有無并發(fā)癥等因素有關(guān)。
[Abstract]:Background: granulomatous Lung Disease. GLDs, or pulmonary granulomatosis). Granulomatous lung disease is a group of pulmonary diseases with different etiology but common pathological features of granuloma. Granulomatous lung disease is common in clinical practice. It includes pulmonary tuberculosis tuberculosis (TBB) and sarcoidosis with high incidence in clinic. Also included in the clinical rare Wegener's granulomatosis or WGG, also known as granulomatous polyvasculitis. Granulomatosis with polyangiitis (GPA). Churg-Strauss syndrome Churg-Stauss Syndromesis-CSSs, also known as allergic granulomatous vasculitis. Allergic granulomatous angitisAGA, also known as eosinophilic granulomatous polyvasculitis. Eosinophilic granulomatosis with polyangiitis) and a variety of rare diseases. The etiology of various diseases is different. There are different characteristics in epidemiology, clinical manifestation, imaging manifestation, laboratory examination and so on. Objective: to explore the clinical characteristics of granulomatous lung disease. The existing diagnosis and treatment methods were summarized in order to improve the understanding and diagnosis and treatment of granulomatous lung diseases. Methods: by searching Pub Med#en0#, Wanfang database and so on. To summarize the etiology and pathogenesis of granulomatous lung disease, pulmonary tuberculosis, sarcoidosis and Wegener's granuloma. The research status of epidemiology, clinical manifestation, diagnosis and treatment of Churg-Strauss syndrome and other four diseases will be summarized. The main points of differential diagnosis between pulmonary tuberculosis and sarcoidosis, Wegener's granuloma and Churg-Strauss 's syndrome were summarized. Conclusion: granulomatous pulmonary disease is based on the etiology of granuloma. Noninfectious granulomatous lung disease includes many diseases whose etiology is not clear, and many factors such as heredity, environment, immunity, infection and so on are considered to be involved in the disease. However, there is no unified consensus. Granuloma formation is the common pathological characteristics of various granulomatous lung diseases, and each type has its own characteristics. These diseases have some characteristics in epidemiology, clinical manifestation, imaging manifestation, laboratory examination and so on, which can provide clues for clinical diagnosis. However, there is still a lack of specificity and sensitivity of the diagnostic methods. Infectious granulomatous lung disease treatment is mainly effective anti-infection and symptomatic support treatment. Sarcoidosis, Wegener granuloma. The treatment of non-infectious granulomatous lung diseases such as Churg-Strauss syndrome is mainly glucocorticoid and immunosuppressant. The prognosis of granulomatous lung disease is closely related to the early effective treatment.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R563.9

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 張京東;高維忠;;黃色肉芽腫性腎孟腎炎2例誤診分析[J];臨床誤診誤治;1990年01期

2 鐘觀林;;慢性肉芽腫性疾患[J];國外醫(yī)學(xué)(臨床放射學(xué)分冊);1982年06期

3 王尚蘭;段西凌;;石膏樣癬菌所致泛發(fā)性肉芽腫性體癬一例報告[J];醫(yī)學(xué)科技;1987年01期

4 何家聲;特發(fā)性肉芽腫性腦膜炎[J];國外醫(yī)學(xué).神經(jīng)病學(xué)神經(jīng)外科學(xué)分冊;1990年04期

5 陳文彬;;原發(fā)性肉芽腫性肺疾病概述[J];中國實用內(nèi)科雜志;1994年10期

6 劉換新;袁懷文;;感染相關(guān)性肉芽腫性淋巴結(jié)炎1例報道[J];武警醫(yī)學(xué)院學(xué)報;2006年04期

7 張德平;孟凡青;;肉芽腫性肺疾病[J];中國呼吸與危重監(jiān)護(hù)雜志;2011年02期

8 周志瑜;中線不愈性肉芽腫[J];國外醫(yī)學(xué).口腔醫(yī)學(xué)分冊;1986年01期

9 鄧采菽;肖波;謝先潔;梁靜慧;;肉芽腫性肌病一例[J];卒中與神經(jīng)疾病;1996年02期

10 宋愛國;陸文熊;;黃色肉芽腫性膽V⒀，

本文編號：1389318