本文關(guān)鍵詞：白介素-33在急性呼吸窘迫綜合征中的研究進展　出處：《重慶醫(yī)科大學學報》2016年04期 　論文類型：期刊論文

  更多相關(guān)文章： 急性呼吸窘迫綜合癥 白介素- 細胞因子 警報素 信號通路

【摘要】：急性呼吸窘迫綜合征(acute respiratory distress syndrome,ARDS)是以頑固性低氧血癥和進行性呼吸困難為主要臨床特點的綜合征,是危重癥患者死亡的主要原因之一。盡管,近年來醫(yī)療技術(shù)的迅猛發(fā)展和新的藥物的應用使ARDS的預后有所改善,但其病死率仍高達40%~50%。因此,更充分的了解ARDS的發(fā)病機制,實現(xiàn)早期診斷,為臨床上ARDS的防治提供指導仍是呼吸和重癥醫(yī)學界研究的重點和熱點。白介素(interleukin,IL)-33是新近發(fā)現(xiàn)的IL-1家族成員,在炎癥、感染、自身免疫性疾病等多種疾病中發(fā)揮重要的警報素作用,促進機體的炎癥反應,加重機體組織的損傷。故IL-33及其信號通路可能成為阻斷炎癥通路的級聯(lián)反應的一個潛在的分子靶點。本文就IL-33在ARDS中的研究進展做一綜述。
[Abstract]:Acute respiratory distress syndrome. ARDS is a syndrome characterized by intractable hypoxemia and progressive dyspnea, and is one of the leading causes of death in critically ill patients. In recent years, with the rapid development of medical technology and the application of new drugs, the prognosis of ARDS has been improved, but its mortality is still as high as 40%. Therefore, the pathogenesis of ARDS is fully understood. To achieve early diagnosis and provide guidance for the prevention and treatment of ARDS in clinic is still the focus and focus of the research of respiratory and critical medicine. IL)-33 is a newly discovered member of IL-1 family, which plays an important role in many diseases, such as inflammation, infection, autoimmune diseases and so on. Therefore, IL-33 and its signaling pathway may become a potential molecular target for blocking the cascade of inflammatory pathways. This paper reviews the progress of IL-33 in ARDS. State.
【作者單位】： 重慶醫(yī)科大學附屬第一醫(yī)院急診醫(yī)學科和重癥醫(yī)學科;
【基金】：國家自然科學基金資助項目(編號:81570069)
【分類號】：R563.8
【正文快照】： 白介素(interleukin,IL)-33是IL-1家族的新成員,在正常人體組織中持續(xù)表達[1-2],具有核內(nèi)調(diào)控基因轉(zhuǎn)錄和核外調(diào)節(jié)炎癥反應的雙重功能[3-4]。目前,IL-33作為炎癥細胞因子的作用及其作用機制越來越受到重視,本文就IL-33在ARDS這一以炎癥反應為中心環(huán)節(jié)的臨床綜合征中的研究進展，

本文編號：1356679