發(fā)布時間：2019-08-12 20:45

【摘要】：目的探究早孕期口服地屈孕酮與新鮮周期輔助生殖單胎孕婦子癇前期發(fā)病的關(guān)聯(lián)性。方法收集2008年1月—2016年6月接受胚胎移植新鮮周期輔助生殖且本院分娩的756例單胎孕婦病例資料進行回顧性隊列研究。按照早孕期孕激素黃體支持是否加用地屈孕酮,分為地屈孕酮組(黃體酮/雪諾酮+地屈孕酮)196例和對照組(黃體酮/雪諾酮)560例,比較組間孕婦子癇前期的發(fā)病率。采用Logistic回歸分析,探究地屈孕酮與子癇前期發(fā)生的關(guān)聯(lián)關(guān)系。結(jié)果地屈孕酮組子癇前期發(fā)病率(1.0%)低于對照組(4.5%,P=0.025)。地屈孕酮組配偶年齡≥40歲、孕婦合并癥的比例均高于對照組(P值分別為0.037、0.048)。將地屈孕酮、配偶年齡及孕婦合并癥納入Logistic回歸分析。多因素分析顯示僅地屈孕酮和子癇前期有統(tǒng)計學(xué)意義的關(guān)聯(lián)(OR=0.221,95%CI=0.052~0.940,P=0.041)。結(jié)論早孕期口服地屈孕酮是新鮮周期輔助生殖孕婦子癇前期發(fā)生的保護因素。
[Abstract]:Objective to investigate the relationship between oral diethylprogesterone in early pregnancy and preeclampsia in fresh cycle assisted reproductive single pregnant women. Methods A retrospective cohort study was conducted on 756 single pregnant women who received fresh cycle assisted reproduction from January 2008 to June 2016. According to whether the progesterone support was added or not, the patients in the early pregnancy group were divided into two groups: the progesterone group (196 cases) and the control group (560 cases). The incidence of preeclampsia between the two groups was compared. Logistic regression analysis was used to explore the relationship between diethylprogesterone and preeclampsia. Results the incidence of preeclampsia in preeclampsia group (1.0%) was lower than that in control group (4.5%, P 鈮，

本文編號：2525944