體外受精-胚胎移植后妊娠早孕期間微量元素變化
發(fā)布時(shí)間：2019-07-09 21:02
【摘要】：目的了解接受外源性性激素治療的體外受精-胚胎移植患者早孕期間血清微量元素水平及雌、孕激素水平的改變情況。方法收集安徽醫(yī)科大學(xué)第一附屬醫(yī)院生殖中心接受體外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)/凍融胚胎移植(frozen-thawed embryo transfer,F-ET)治療后獲妊娠者800例及自然妊娠者63例,按周期類型分為新鮮周期組(212例)、解凍人工周期組(354例)、解凍自然周期組(234例)和自然妊娠組(63例)。在妊娠后6~8周于清晨空腹測(cè)血銅、鋅、鈣、鎂、鐵五種常見微量元素值及雌二醇(estradiol,E2)、孕酮(progesterone,P)水平。結(jié)果隨IVF-ET不同方案外源性激素?cái)z入量增加,孕婦血清E2、P水平逐漸升高,自然妊娠組最低,新鮮周期組最高。四組血清銅含量間差異有統(tǒng)計(jì)學(xué)意義(均有P0.05),自然妊娠組最低,解凍人工周期組最高,且銅水平與雌二醇水平呈正相關(guān)(r=0.08,P=0.024)。多胎妊娠者血清鎂、鐵均低于單胎妊娠者(均有P0.05)。結(jié)論接受IVF-ET/F-ET治療后獲妊娠者早孕期間血清銅較同期自然妊娠者高,且與其血清E2水平呈正相關(guān)。多胎妊娠對(duì)鎂、鐵的需求較單胎妊娠高。
[Abstract]:Objective to investigate the changes of serum trace elements and estrogen and progesterone levels in patients undergoing in vitro fertilisation and embryo transfer treated with exogenous sex hormones. Methods cases of pregnancy and 63 cases of natural pregnancy were collected from the Reproductive Center of the first affiliated Hospital of Anhui Medical University after in vitro fertilization and embryo transfer (in vitro fertilization-embryo transfer,IVF-ET) / freeze-thawed embryo transfer (frozen-thawed embryo transfer,F-ET). They were divided into fresh cycle group (n = 212), thawed artificial cycle group (n = 34) and natural pregnancy group (n = 63) according to the type of cycle. The levels of copper, zinc, calcium, magnesium and iron and the levels of estradiol,E2 and progesterone,P were measured on an empty stomach at 6: 8 weeks after pregnancy. Results with the increase of exogenous hormone intake in different regimens of IVF-ET, the serum E2 and P levels of pregnant women increased gradually, the natural pregnancy group was the lowest, and the fresh cycle group was the highest. There was significant difference in serum copper content among the four groups (P 0.05). The natural pregnancy group was the lowest and the thawed artificial cycle group was the highest, and the copper level was positively correlated with the level of estrogen (r 鈮，
本文編號(hào)：2512448
[Abstract]:Objective to investigate the changes of serum trace elements and estrogen and progesterone levels in patients undergoing in vitro fertilisation and embryo transfer treated with exogenous sex hormones. Methods cases of pregnancy and 63 cases of natural pregnancy were collected from the Reproductive Center of the first affiliated Hospital of Anhui Medical University after in vitro fertilization and embryo transfer (in vitro fertilization-embryo transfer,IVF-ET) / freeze-thawed embryo transfer (frozen-thawed embryo transfer,F-ET). They were divided into fresh cycle group (n = 212), thawed artificial cycle group (n = 34) and natural pregnancy group (n = 63) according to the type of cycle. The levels of copper, zinc, calcium, magnesium and iron and the levels of estradiol,E2 and progesterone,P were measured on an empty stomach at 6: 8 weeks after pregnancy. Results with the increase of exogenous hormone intake in different regimens of IVF-ET, the serum E2 and P levels of pregnant women increased gradually, the natural pregnancy group was the lowest, and the fresh cycle group was the highest. There was significant difference in serum copper content among the four groups (P 0.05). The natural pregnancy group was the lowest and the thawed artificial cycle group was the highest, and the copper level was positively correlated with the level of estrogen (r 鈮，
本文編號(hào)：2512448
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