【摘要】：目的：比較β-catenin蛋白及ABCG-2蛋白在子宮肉瘤組織及子宮肌瘤、正常子宮肌層中的表達,探討β-catenin蛋白及ABCG-2蛋白在子宮肉瘤發(fā)病機制中的作用。 方法：采用免疫組化SP二步法檢測β-catenin蛋白及ABCG-2蛋白在90例子宮肉瘤中的表達,比較不同病理類型子宮肉瘤,不同惡性程度以及不同臨床分期的子宮肉瘤之間的表達差異。并對二者的蛋白表達量進行相關性分析。 結(jié)果：1.β-catenin蛋白、ABCG-2蛋白在子宮肉瘤中陽性表達率分別為87%、82%,表達水平分別為(4.9±2.86)、(3.84±2.58)；在子宮平滑肌瘤細胞中的陽性表達率分別為3.3%、6.7%,表達水平為(0.20±0.81)、(0.201±0.81)；正常子宮平滑肌組織中陽性表達率3.3%、3.3%,表達水平為(0.067±0.305)、(0.07±0.305)。二者在子宮肉瘤組織中陽性表達率明顯高于在子宮平滑肌瘤組織及正常子宮平滑肌組織中的陽性表達率,差異有統(tǒng)計學意義(P0.05)；而二者在子宮平滑肌瘤組織及正常子宮平滑肌組織中的陽性表達率之間的差異無統(tǒng)計學意義(P0.05)。 2.在β-catenin蛋白、ABCG-2蛋白在子宮平滑肌肉瘤陽性表達率分別為87%、83%,表達水平分別為(4.93±2.86)、(3.6±2.12)；子宮內(nèi)膜間質(zhì)肉瘤中的陽性表達率分別為80%、77%,表達水平分別為(4.80±3.30)、(3.2±2.13)；在子宮癌肉瘤中陽性表達率分別93%、87%,表達水平分別為(4.67±2.70)、(4.7±3.17)。二者在子宮平滑肌肉瘤組織中陽性表達率與子宮內(nèi)膜間質(zhì)肉瘤及子宮癌肉瘤組織中的陽性表達率,兩兩相比差異無統(tǒng)計學意義(P0.05)。 3. β-catenin蛋白、ABCG-2蛋白在Ⅰ-Ⅱ期子宮肉瘤陽性表達率分別為74%,65%,表達水平分別為(3.28±0.20)、(2.94±0.47)；在Ⅲ-Ⅳ期子宮肉瘤陽性表達率分別為98%、93%,表達水平分別為(7.15±0.21)、(4.39±0.32)；在Ⅲ-Ⅳ期子宮肉瘤組中陽性表達率明顯高于在Ⅰ-Ⅱ期子宮肉瘤組中陽性表達率,差異有統(tǒng)計學意義(P0.05)。 4.高度惡性子宮內(nèi)膜間質(zhì)肉瘤的陽性表達率為91%,表達水平為(6.91±0.78)。 結(jié)論： 1. β-catenin蛋白、ABCG2蛋白在子宮肉瘤中的高表達提示二者在子宮肉瘤的發(fā)生發(fā)展中可能起重要作用。 2. β-catenin蛋白、ABCG2蛋白在各類型子宮肉瘤和子宮低度和高度惡性內(nèi)膜間質(zhì)肉瘤中的表達無統(tǒng)計學差異,提示β-catenin蛋白、ABCG2蛋白與子宮肉瘤病理類型和惡性程度無明顯關系。 3. β-catenin蛋白、ABCG2蛋白在Ⅲ-Ⅳ期子宮肉瘤中的表達明顯高于Ⅰ-Ⅱ期,提示二者與子宮肉瘤的病情嚴重程度有關。 4. β-catenin蛋白及ABCG2蛋白表達在子宮肉瘤中成正相關,提示二者可能協(xié)同促進子宮肉瘤的發(fā)生發(fā)展。
[Abstract]:Aim: to compare the expression of 尾-catenin protein and ABCG-2 protein in uterine sarcomas, uterine fibroids and normal myocytes, and to explore the role of 尾-catenin protein and ABCG-2 protein in the pathogenesis of uterine sarcomas. Methods: the expression of 尾-catenin protein and ABCG-2 protein in 90 cases of uterine sarcomas was detected by immunohistochemical SP two-step method. The expression of 尾-catenin protein and ABCG-2 protein in different pathological types of uterine sarcomas, different malignant degrees and different clinical stages of uterine sarcomas was compared. The correlation between the protein expression of the two proteins was analyzed. Results: 1. The positive expression rates of 尾-catenin protein and ABCG-2 protein in uterine sarcomas were 87% and 82%, respectively, and the expression levels were (4.9 鹵2.86), (3.84 鹵2.58), 3.3%, 6.7% and (0. 20 鹵0. 81), (0.201 鹵0. 81), respectively. The positive expression rate was 3.3% and 3.3% in normal uterine smooth muscle tissues, and the expression level was (0.067 鹵0.305), (0.07 鹵0.305). The positive expression rate of the two groups in uterine leiomyoma and normal uterine smooth muscle tissue was significantly higher than that in uterine leiomyoma tissue and normal uterine smooth muscle tissue (P 0.05), but there was no significant difference between the two groups in uterine leiomyoma tissue and normal uterine smooth muscle tissue (P 0.05). two銆，

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