【摘要】：目的探討羊水栓塞(AFE)孕兔血漿組織因子(TF)水平與凝血功能障礙的關(guān)系。方法將30只健康孕晚期家兔隨機(jī)分為A、B、C組各10只,分別經(jīng)耳緣靜脈輸入1%羊水胎糞混合液、自體羊水2.5 mL/kg及等量生理鹽水。分別于羊水注射前及注射后30 min,耳緣靜脈取血檢測血漿TF水平及凝血指標(biāo)[凝血酶原時間(PT)、活化部分凝血活酶時間(APTT)、凝血酶時間(TT)及纖維蛋白原(FIB)]。結(jié)果各組注射前血漿TF及凝血功能指標(biāo)比較差異無統(tǒng)計學(xué)意義(P均0.05),A、B組注射后較同組注射前及C組注射后血漿TF水平升高,PT、APTT、TT延長而FIB減少(P均0.05),且A組各指標(biāo)變化大于B組(P均0.05)。血漿TF與PT、APTT、TT呈正相關(guān)(r分別為0.95、0.86、0.89,P均0.05),與FIB呈負(fù)相關(guān)(r=-0.92,P0.05)。結(jié)論 AFE發(fā)生時羊水中的TF大量進(jìn)入母體血液循環(huán),從而激活外源性凝血途徑,引起母體凝血功能障礙。
[Abstract]:Objective to investigate the relationship between plasma tissue factor (TF) level and coagulation dysfunction in pregnant rabbits with amniotic fluid embolism (AFE). Methods 30 healthy rabbits in the third trimester of pregnancy were randomly divided into group A (n = 10) and group C (n = 10). 1% amniotic fluid meconium mixture, autologous amniotic fluid 2.5 mL/kg and the same amount of saline were infused into the ear margin vein, respectively. Plasma TF level and coagulation index were measured before amniotic fluid injection and 30 min, after amniotic fluid injection [prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB)]. Results there was no significant difference in plasma TF and coagulation function between the two groups before injection, but there was no significant difference in plasma TF and coagulation function between the two groups before injection. The plasma TF level and PT,APTT, in group B were higher than those before injection and group C after injection. TT prolonged and FIB decreased, and the changes of each index in group A were higher than those in group B (P < 0.05). Plasma TF was positively correlated with PT,APTT,TT (r = 0.95, 0.86, 0.89, P 0.05), and negatively correlated with FIB (r 鈮，

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