長(zhǎng)方案促排卵過程中血清LH低于正常值時(shí)補(bǔ)充LH對(duì)助孕結(jié)局的影響
發(fā)布時(shí)間：2019-05-07 15:06
【摘要】：目的探討在體外受精-胚胎移植(IVF-ET)周期長(zhǎng)方案促排卵過程中晚卵泡期血清促黃體生成素(LH)低于正常值時(shí),補(bǔ)充基因重組人黃體生成素(r-hLH)或人絕經(jīng)期尿促性腺激素(HMG)對(duì)IVF-ET助孕結(jié)局的影響。方法采用回顧性分析,選擇因女方輸卵管因素行IVF-ET助孕的患者529例,所有患者均采用標(biāo)準(zhǔn)長(zhǎng)方案,單用基因重組促卵泡激素(rFSH)促排卵。根據(jù)年齡、晚卵泡期血清LH、是否補(bǔ)充外源性LH將所有患者分成6組:35歲的A組血清LH1.2mU/mL,單用rFSH促排46例,B組血清LH1.2mU/mL,補(bǔ)充r-hLH 52例,C組血清LH1.2mU/mL,補(bǔ)充HMG 257例;≥35歲的D組血清LH1.2mU/mL,單用rFSH促排34例,E組血清LH1.2mU/mL,補(bǔ)充rhLH 41例,F組血清LH1.2mU/mL,補(bǔ)充HMG 99例。結(jié)果 35歲的3組患者之間和≥35歲的3組患者之間在年齡、不孕年限、BMI,基礎(chǔ)FSH、LH、E2水平,Gn使用天數(shù)、Gn用量,HCG日LH、P水平,HCG日內(nèi)膜厚度及獲卵數(shù)等方面差異均無(wú)統(tǒng)計(jì)學(xué)意義(均P0.05)。B組及E組rFSH總量分別高于C組及F組,差異有統(tǒng)計(jì)學(xué)意義(均P0.05);B組及F組E2水平及2PN受精率分別明顯高于A組及D組,差異有統(tǒng)計(jì)學(xué)意義(均P0.05);A、B、C組之間優(yōu)質(zhì)胚胎率及妊娠率比較差異無(wú)統(tǒng)計(jì)學(xué)意義(均P0.05);E組優(yōu)質(zhì)胚胎率及妊娠率明顯高于D組,差異有統(tǒng)計(jì)學(xué)意義(均P0.05)。結(jié)論口服避孕藥降調(diào)長(zhǎng)方案晚卵泡期血LH值1.2mU/mL時(shí),適量添加r-hLH可以改善卵子質(zhì)量,提高受精率,改善妊娠結(jié)局,尤其是明顯提高≥35歲患者的臨床妊娠率、受精率及優(yōu)胚率。
[Abstract]:Objective to investigate whether the serum luteinizing hormone (LH) in late follicular phase of in vitro fertilization-embryo transfer (IVF-ET) is lower than normal in the course of ovulation induction by long-term regimen of in vitro fertilization-embryo transfer (IVEF). Effects of recombinant human luteinizing hormone (r-hLH) or human gonadotropin (HMG) on the outcome of IVF-ET assisted pregnancy. Methods A retrospective analysis was conducted in 529 patients who were assisted with IVF-ET due to fallopian tube factors. All patients were treated with standard long-term regimen using recombinant follicle-stimulating hormone (rFSH) alone to induce ovulation. According to age, serum LH, in late follicular phase was supplemented with exogenous LH. All patients were divided into 6 groups: 46 cases of serum LH1.2mU/mL, in group A (35 years old) and 52 cases of serum LH1.2mU/mL, supplemented with r-hLH (group B), and 46 cases of serum LH1.2mU/mL, in group A (35 years old). In group C, serum LH1.2mU/mL, was supplemented with HMG in 257 cases; Serum LH1.2mU/mL, in group D (鈮，
本文編號(hào)：2471178
[Abstract]:Objective to investigate whether the serum luteinizing hormone (LH) in late follicular phase of in vitro fertilization-embryo transfer (IVF-ET) is lower than normal in the course of ovulation induction by long-term regimen of in vitro fertilization-embryo transfer (IVEF). Effects of recombinant human luteinizing hormone (r-hLH) or human gonadotropin (HMG) on the outcome of IVF-ET assisted pregnancy. Methods A retrospective analysis was conducted in 529 patients who were assisted with IVF-ET due to fallopian tube factors. All patients were treated with standard long-term regimen using recombinant follicle-stimulating hormone (rFSH) alone to induce ovulation. According to age, serum LH, in late follicular phase was supplemented with exogenous LH. All patients were divided into 6 groups: 46 cases of serum LH1.2mU/mL, in group A (35 years old) and 52 cases of serum LH1.2mU/mL, supplemented with r-hLH (group B), and 46 cases of serum LH1.2mU/mL, in group A (35 years old). In group C, serum LH1.2mU/mL, was supplemented with HMG in 257 cases; Serum LH1.2mU/mL, in group D (鈮，
本文編號(hào)：2471178
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