【摘要】：目的:觀察貞芪扶正顆粒輔助治療宮頸癌的療效和安全性。方法:86例宮頸癌患者隨機(jī)分為對照組(43例)和觀察組(43例)。對照組患者于化療前0.5 h分別靜脈滴注鹽酸苯海拉明注射液20 mg,鹽酸格拉司瓊葡萄糖注射液5 mg,西咪替丁注射液20mg,靜脈滴注0.5 h后開始化療:多西他賽注射液40 mg/m~2,d1,d8,靜脈滴注;注射用順鉑25 mg/m~2,d1-3,靜脈滴注;21 d為1個周期,共4~6個周期。觀察組患者在對照組治療的基礎(chǔ)上口服貞芪扶正顆粒5 g,每日2次。觀察兩組患者的臨床療效,治療前后T細(xì)胞亞群指標(biāo)[CD3+、CD4+、CD8+、自然殺傷細(xì)胞(NK)]、功能狀態(tài)(KPS)評分,化療終止情況、終止時間、化療次數(shù)及毒副反應(yīng)發(fā)生情況。結(jié)果:觀察組患者總緩解率顯著高于對照組,觀察組化療終止患者占比顯著少于對照組,化療終止時間顯著短于對照組,化療次數(shù)顯著多于對照組,胃腸道反應(yīng)、貧血、血小板降低、白細(xì)胞下降發(fā)生率均顯著低于對照組,差異均有統(tǒng)計學(xué)意義(P0.05);兩組患者肝功能損傷、腎功能損傷、口腔炎發(fā)生率比較,差異均無統(tǒng)計學(xué)意義(P0.05)。治療前,兩組患者T細(xì)胞亞群指標(biāo)及KPS評分比較,差異均無統(tǒng)計學(xué)意義(P0.05)。治療后,觀察組患者CD3+、CD4+、NK細(xì)胞水平均顯著高于同組治療前及對照組,CD8+水平顯著低于同組治療前及對照組;兩組患者KPS評分均顯著高于同組治療前,且觀察組顯著高于對照組,差異均有統(tǒng)計學(xué)意義(P0.05);對照組患者治療前后T細(xì)胞亞群指標(biāo)比較,差異均無統(tǒng)計學(xué)意義(P0.05)。結(jié)論:在常規(guī)治療的基礎(chǔ)上,貞芪扶正顆�？商岣邔m頸癌患者的療效,改善機(jī)體免疫功能,提高生存質(zhì)量,降低毒副反應(yīng)。
[Abstract]:Objective: to observe the efficacy and safety of Zhenqi Fuzheng granule in the treatment of cervical cancer. Methods: 86 cases of cervical cancer were randomly divided into control group (43 cases) and observation group (43 cases). The patients in the control group were given diphenhydramine hydrochloride injection 20 mg, granisetron hydrochloride glucose injection 5 mg, cimetidine injection 20 mg, respectively, 0.5 h before chemotherapy. After intravenous infusion for 0.5 h, chemotherapy was started: 40 mg/m~2,d1,d8, of docetaxel injection was given intravenously; Cisplatin was injected intravenously for 25 mg/m~2,d1-3, 21 days as a cycle, a total of 4 cycles for 6 cycles. The patients in the observation group took Zhenqi Fuzheng granule 5 g twice a day on the basis of treatment in the control group. To observe the clinical efficacy of the two groups, T cell subgroup indexes [CD3, CD4, CD8, natural killer cell (NK)], functional status (KPS) score, chemotherapy termination, termination time, chemotherapy times and side effects before and after treatment. Results: the total remission rate of the observation group was significantly higher than that of the control group. The proportion of patients with chemotherapy termination in the observation group was significantly less than that in the control group, the termination time of chemotherapy was significantly shorter than that in the control group, and the number of chemotherapy was significantly higher than that in the control group. The incidence of platelet reduction and leukopenia was significantly lower than that of the control group (P0.05). There was no significant difference in the incidence of liver function injury, renal function injury and stomatitis between the two groups (P0.05). Before treatment, there was no significant difference in T lymphocyte subsets and KPS scores between the two groups (P0.05). After treatment, the levels of CD3, CD4 and NK cells in the observation group were significantly higher than those in the same group before treatment and in the control group, while the level of CD8 in the observation group was significantly lower than that before treatment and in the control group. The KPS score of the two groups was significantly higher than that of the same group before treatment, and that of the observation group was significantly higher than that of the control group, the difference was statistically significant (P0.05). There was no significant difference in T cell subsets before and after treatment in the control group (P0.05). Conclusion: on the basis of routine treatment, Zhenqi Fuzheng granule can improve the curative effect of cervical cancer patients, improve the immune function of the body, improve the quality of life and reduce the toxic and side effects.
【作者單位】： 蘭州市婦幼保健院藥劑科;蘭州市婦幼保健院婦科;蘭州市婦幼保健院病理科;
【分類號】：R737.33

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