【摘要】：目的檢測(cè)正常妊娠和子癇前期(preeclampsia)患者血漿網(wǎng)膜素(Omentin)及瘦素(Leptin)的水平變化,探究其與子癇前期的發(fā)病關(guān)系及意義,從而探討網(wǎng)膜素及瘦素是否對(duì)子癇前期有預(yù)測(cè)價(jià)值；分析網(wǎng)膜素與瘦素、血脂的相關(guān)性,初步探討網(wǎng)膜素及瘦素在子癇前期發(fā)病中的可能機(jī)制。 方法采用酶聯(lián)免疫吸附試驗(yàn)法檢測(cè)30例正常健康孕婦(A組)、30例子癇前期輕度孕婦(B組)、30例子癇前期重度孕婦(C組)的血漿Omentin及Leptin水平；同時(shí)測(cè)定所有受試者的脂生化指標(biāo)。 結(jié)果(1)子癇前期孕婦收縮壓(SBP)、舒張壓(DBP)。甘油三酯(TG)、總膽固醇(TC)、低密度脂蛋白膽固醇(LDL-C)均高于正常對(duì)照組,高密度脂蛋白膽固醇(HDL-C)低于正常對(duì)照組。(均P0.05)；(2)對(duì)照組、輕度子癇前期、重度子癇前期孕婦血漿Omentin濃度逐漸降低,分別為(400.05±211.9)ng/L,(307.03±230.34)ng/L,(155.84±20.71)ng/L],兩兩比較差異顯著(P0.05);對(duì)照組、輕度子癇前期、重度子癇前期孕婦血漿Leptin水平濃度逐漸升高,分別為(37.38±15.16)ng/mL,(54.59±16.89) ng/mL,(110.25±31.45) ng/mL,兩兩比較差異顯著(P0.05)；(3)血漿Omentin水平與HDL-C呈正相關(guān),與BMI、收縮壓呈負(fù)相關(guān)(P0.05)；(4)多元逐步回歸分析顯示,BMI、收縮壓是影響血漿Omentin水平的重要因素(P0.05) 結(jié)論子癇前期孕婦存在脂代謝異常,子癇前期患者血漿網(wǎng)膜素濃度顯著低于正常健康孕婦,患者病情越重,血漿中網(wǎng)膜素的濃度越低。相反,子癇前期患者的血漿瘦素濃度顯著高于正常健康孕婦,血漿瘦素的濃度隨著病情加重而升高。Pearson相關(guān)分析顯示,血漿網(wǎng)膜素水平與瘦素呈負(fù)相關(guān)。提示網(wǎng)膜素及瘦素在子癇前期發(fā)生發(fā)展中的作用存在關(guān)聯(lián)。如孕期聯(lián)合測(cè)定血漿omentin及l(fā)eptin,將有可能成為疾病的預(yù)測(cè)指標(biāo)。
[Abstract]:Objective to detect the changes of plasma levels of omental (Omentin) and leptin (Leptin) in normal pregnancy and preeclampsia (preeclampsia) patients, and to explore their relationship with preeclampsia. So as to explore whether omentofin and leptin have predictive value in preeclampsia. To explore the possible mechanism of omentofin and leptin in preeclampsia. Methods the levels of plasma Omentin and Leptin in 30 normal pregnant women (group A), 30 cases of mild preeclampsia (group B) and 30 cases of severe preeclampsia (group C) were detected by enzyme-linked immunosorbent assay (Elisa). At the same time, the lipid biochemical indexes of all subjects were measured. Results (1) systolic blood pressure (SBP),) diastolic blood pressure (DBP).) in preeclampsia pregnant women Triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) was higher than normal control group and high density lipoprotein cholesterol (HDL-C) was lower than that of normal control group. (P0.05); (2) in the control group, the plasma Omentin concentrations of mild preeclampsia and severe preeclampsia decreased gradually, which were (400.05 鹵211.9) ng/L, (307.03 鹵230.34) ng/L, (155.84 鹵20.71) ng/L, respectively. The difference was significant (P0.05). In the control group, the plasma Leptin levels of mild preeclampsia and severe preeclampsia were (37.38 鹵15.16) ng/mL, (54.59 鹵16.89) ng/mL, (110.25 鹵31.45) ng/mL, respectively. The difference was significant (P0.05). (3) the plasma Omentin level was positively correlated with HDL-C and negatively correlated with BMI, systolic blood pressure (P0.05). (4) multivariate stepwise regression analysis showed that BMI, systolic blood pressure was an important factor affecting plasma Omentin level (P0.05). Conclusion there is abnormal lipid metabolism in preeclampsia pregnant women. The concentration of omentin in preeclampsia patients was significantly lower than that in normal pregnant women. On the contrary, the plasma leptin concentration in preeclampsia patients was significantly higher than that in normal pregnant women, and the plasma leptin concentration increased with the severity of the disease. Pearson correlation analysis showed that the plasma leptin level was negatively correlated with leptin. The results suggest that the role of omental hormone and leptin in the development of preeclampsia is associated with the development of preeclampsia. Combined determination of plasma omentin and leptin, during pregnancy may be a predictor of disease.
【學(xué)位授予單位】：蘭州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R714.244

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