【摘要】：目的檢測正常妊娠和子癇前期(preeclampsia)患者血漿網膜素(Omentin)及瘦素(Leptin)的水平變化,探究其與子癇前期的發(fā)病關系及意義,從而探討網膜素及瘦素是否對子癇前期有預測價值；分析網膜素與瘦素、血脂的相關性,初步探討網膜素及瘦素在子癇前期發(fā)病中的可能機制。 方法采用酶聯免疫吸附試驗法檢測30例正常健康孕婦(A組)、30例子癇前期輕度孕婦(B組)、30例子癇前期重度孕婦(C組)的血漿Omentin及Leptin水平；同時測定所有受試者的脂生化指標。 結果(1)子癇前期孕婦收縮壓(SBP)、舒張壓(DBP)。甘油三酯(TG)、總膽固醇(TC)、低密度脂蛋白膽固醇(LDL-C)均高于正常對照組,高密度脂蛋白膽固醇(HDL-C)低于正常對照組。(均P0.05)；(2)對照組、輕度子癇前期、重度子癇前期孕婦血漿Omentin濃度逐漸降低,分別為(400.05±211.9)ng/L,(307.03±230.34)ng/L,(155.84±20.71)ng/L],兩兩比較差異顯著(P0.05);對照組、輕度子癇前期、重度子癇前期孕婦血漿Leptin水平濃度逐漸升高,分別為(37.38±15.16)ng/mL,(54.59±16.89) ng/mL,(110.25±31.45) ng/mL,兩兩比較差異顯著(P0.05)；(3)血漿Omentin水平與HDL-C呈正相關,與BMI、收縮壓呈負相關(P0.05)；(4)多元逐步回歸分析顯示,BMI、收縮壓是影響血漿Omentin水平的重要因素(P0.05) 結論子癇前期孕婦存在脂代謝異常,子癇前期患者血漿網膜素濃度顯著低于正常健康孕婦,患者病情越重,血漿中網膜素的濃度越低。相反,子癇前期患者的血漿瘦素濃度顯著高于正常健康孕婦,血漿瘦素的濃度隨著病情加重而升高。Pearson相關分析顯示,血漿網膜素水平與瘦素呈負相關。提示網膜素及瘦素在子癇前期發(fā)生發(fā)展中的作用存在關聯。如孕期聯合測定血漿omentin及l(fā)eptin,將有可能成為疾病的預測指標。
[Abstract]:Objective to detect the changes of plasma levels of omental (Omentin) and leptin (Leptin) in normal pregnancy and preeclampsia (preeclampsia) patients, and to explore their relationship with preeclampsia. So as to explore whether omentofin and leptin have predictive value in preeclampsia. To explore the possible mechanism of omentofin and leptin in preeclampsia. Methods the levels of plasma Omentin and Leptin in 30 normal pregnant women (group A), 30 cases of mild preeclampsia (group B) and 30 cases of severe preeclampsia (group C) were detected by enzyme-linked immunosorbent assay (Elisa). At the same time, the lipid biochemical indexes of all subjects were measured. Results (1) systolic blood pressure (SBP),) diastolic blood pressure (DBP).) in preeclampsia pregnant women Triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) was higher than normal control group and high density lipoprotein cholesterol (HDL-C) was lower than that of normal control group. (P0.05); (2) in the control group, the plasma Omentin concentrations of mild preeclampsia and severe preeclampsia decreased gradually, which were (400.05 鹵211.9) ng/L, (307.03 鹵230.34) ng/L, (155.84 鹵20.71) ng/L, respectively. The difference was significant (P0.05). In the control group, the plasma Leptin levels of mild preeclampsia and severe preeclampsia were (37.38 鹵15.16) ng/mL, (54.59 鹵16.89) ng/mL, (110.25 鹵31.45) ng/mL, respectively. The difference was significant (P0.05). (3) the plasma Omentin level was positively correlated with HDL-C and negatively correlated with BMI, systolic blood pressure (P0.05). (4) multivariate stepwise regression analysis showed that BMI, systolic blood pressure was an important factor affecting plasma Omentin level (P0.05). Conclusion there is abnormal lipid metabolism in preeclampsia pregnant women. The concentration of omentin in preeclampsia patients was significantly lower than that in normal pregnant women. On the contrary, the plasma leptin concentration in preeclampsia patients was significantly higher than that in normal pregnant women, and the plasma leptin concentration increased with the severity of the disease. Pearson correlation analysis showed that the plasma leptin level was negatively correlated with leptin. The results suggest that the role of omental hormone and leptin in the development of preeclampsia is associated with the development of preeclampsia. Combined determination of plasma omentin and leptin, during pregnancy may be a predictor of disease.
【學位授予單位】：蘭州大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R714.244

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