【摘要】：目的探討腦源性神經(jīng)營養(yǎng)因子(BDNF)及其低親和力受體P75在ⅠB1~ⅡB期宮頸鱗癌及正常宮頸組織中的表達(dá)特點(diǎn)及表達(dá)位置關(guān)系。方法收集南方醫(yī)科大學(xué)南方醫(yī)院婦科2014—2016年ⅠB1~ⅡB期宮頸鱗癌病例124例,用免疫組織化學(xué)、免疫熒光及生物體視學(xué)圖像分析法觀察124例宮頸鱗癌及10例正常宮頸BDNF及P75的表達(dá)分布、定量情況及位置關(guān)系。結(jié)果 BDNF及P75受體均主要表達(dá)于宮頸鱗癌細(xì)胞及正常宮頸上皮細(xì)胞的細(xì)胞膜、其次為膜漿共表達(dá)。BDNF及P75的表達(dá)部位之間差異有統(tǒng)計學(xué)意義(χ2=4.127,P=0.042),兩者表達(dá)位置之間無相關(guān)性(B=1.246,P0.05)。在宮頸鱗癌中,BDNF的表達(dá)量低于正常宮頸(t=4.289,P=0.04);P75則高于正常宮頸(t=9.970,P=0.002)。BDNF、P75膜漿共表達(dá)組分期高于膜表達(dá)組(χ2=22.841,P=0.000)、(χ2=23.442,P=0.000)。各分期宮頸鱗癌BDNF及P75表達(dá)量之間差異無統(tǒng)計學(xué)意義(F=0.545,P=0.703)、(F=1.673,P=0.162)。結(jié)論腦源性神經(jīng)營養(yǎng)因子及其低親和力受體P75可能參與宮頸鱗癌的發(fā)生,且其兩者之間存在一定關(guān)系,共同作用于腫瘤的生長。
[Abstract]:Objective to investigate the expression of brain-derived neurotrophic factor (BDNF) and its low affinity receptor (P75) in cervical squamous cell carcinoma (SCC) and normal cervical tissues. Methods 124 cases of cervical squamous cell carcinoma from 2014 to 2016 in Southern Hospital of Southern Medical University were collected. The expression of BDNF and P75 in 124 cases of cervical squamous cell carcinoma and 10 cases of normal cervix were observed by immunofluorescence and biological image analysis. Results BDNF and P75 receptors were mainly expressed in the cell membrane of cervical squamous cell carcinoma and normal cervix epithelium, followed by the co-expression of BDNF and P75. There was significant difference between the expression sites of BDNF and P75 (蠂 2, 4.127, P 0.042). There was no correlation between the two expression positions (P 0.05). The expression of BDNF in squamous cell carcinoma of cervix was lower than that in normal cervix (t = 4.289). P75 was higher than that of normal cervix (tn970), and the stage of co-expression of BDNF,P75 was higher than that of membranous expression (蠂 2 + 22.841), (蠂 2 23. 442P 0. 000). There was no significant difference in the expression of BDNF and P75 among different stages of cervical squamous cell carcinoma (FG 0.545U / P 0.703), (/ F 1.673 / P = 0.162). Conclusion brain-derived neurotrophic factor and its low affinity receptor P75 may be involved in the development of cervical squamous cell carcinoma, and there is a certain relationship between them.
【作者單位】： 南方醫(yī)科大學(xué)南方醫(yī)院婦產(chǎn)科;南方醫(yī)科大學(xué)南方醫(yī)院病理科;
【基金】：國家科技支撐計劃(2014BAI05B03) 國家自然科學(xué)基金(81272585) 廣東省自然科學(xué)基金—重點(diǎn)項目(2015A030311024) 廣東省醫(yī)學(xué)科研基金(20151222283499) 廣州市科技計劃(158100075) 南方醫(yī)院高層次匹配課題(201406);南方醫(yī)院院長基金(2015C015)
【分類號】：R737.33

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