【摘要】：目的探討不良妊娠史ABO型血孕婦產(chǎn)前檢測(cè)血清Ig G抗體效價(jià)的臨床意義。方法選取既往不良妊娠史孕婦92例(血清標(biāo)本),其中母子ABO血型不合86例,Rh血型不合6例。分別檢測(cè)孕婦血清中Ig G抗A(B)抗體效價(jià)及Ig G抗C(D)抗體效價(jià),對(duì)Ig G抗體效價(jià)較高存在新生兒溶血病(HDN)發(fā)病風(fēng)險(xiǎn)孕婦進(jìn)行孕期干預(yù)。結(jié)果 ABO血型不合86例,確診HDN 52例,HDN發(fā)生率為60%。Ig G抗A(B)抗體效價(jià)1∶64孕婦11例,經(jīng)菌陳湯治療后均分娩健康嬰兒;Ig G抗A(B)抗體效價(jià)≥1∶128孕婦77例,經(jīng)吸氧、靜脈滴注維生素C等治療,59例胎兒出生并存活,但均存在不同程度黃疸,后經(jīng)光療、靜滴丙種球蛋白治療痊愈。Rh血型不合6例,孕婦Ig G抗D抗體陽(yáng)性5例,抗體效價(jià)為1∶16;Ig G抗C抗體陽(yáng)性1例(死胎)。5例Ig G抗D抗體陽(yáng)性孕婦孕期行血漿去除及靜滴丙種球蛋白治療,1例胎兒出生2 h死亡,4例胎兒出生臨床確診為均Rh血型不合HDN行換血治療治愈出院。結(jié)論既往不良妊娠史ABO型孕婦存在較高的HDN發(fā)病風(fēng)險(xiǎn),產(chǎn)前檢測(cè)血型lg G抗體效價(jià)并及時(shí)治療干預(yù)對(duì)預(yù)防HDN的發(fā)生有重要意義。
[Abstract]:Objective to investigate the clinical significance of prenatal detection of serum IgG antibody in ABO type pregnant women with adverse pregnancy history. Methods 92 pregnant women (serum samples) with previous adverse pregnancy history were selected, including 86 cases of maternal and child ABO blood group incompatibility and 6 cases of Rh blood group incompatibility. The titer of IgG anti-A (B) antibody and IgG anti-C (D) antibody in pregnant women's serum were detected respectively. The pregnant women with high Ig G antibody titer were treated with high risk of neonatal hemolytic disease (HDN). Results 86 cases of ABO blood group incompatibility, 52 cases of confirmed HDN with HDN incidence of 60.Ig G anti-A (B) antibody titer of 11 pregnant women with 1:64 antibody titer, and 77 cases of pregnant women with Ig G anti-A (B) antibody titer 鈮，

本文編號(hào)：2126911