本文選題：先天性心臟病 + 葉酸�。� 參考：《山東醫(yī)藥》2015年37期

【摘要】：目的觀察孕婦血清葉酸(FA)和同型半胱氨酸(Hcy)水平變化并探討其與胎兒先天性心臟病(CHD)的關(guān)系。方法選擇有胎兒CHD的孕婦46例為病例組,無胎兒CHD的孕婦43例為對(duì)照組。采用競(jìng)爭(zhēng)法測(cè)定血清FA水平,酶法測(cè)定血清Hcy水平,比較兩組血清FA和Hcy水平的差異。采用單因素及多因素Logistic回歸分析各指標(biāo)間的相關(guān)性。結(jié)果病例組的FA水平低于對(duì)照組(t=2.426,P0.017);病例組Hcy水平高于對(duì)照組,但差異無統(tǒng)計(jì)學(xué)意義(P0.05)。孕婦體質(zhì)量高、血清FA水平低是胎兒發(fā)生CHD的危險(xiǎn)因素。血清FA≥41.6 nmol/L的孕婦與32.5 nmol/L的孕婦相比,胎兒CHD發(fā)生率降低36倍,是胎兒患CHD的保護(hù)因素;Hcy的OR=1.036,95%CI:0.807~1.329,但并未增加胎兒CHD發(fā)生的危險(xiǎn)性(P0.05)。結(jié)論孕婦血清高水平FA是胎兒CHD的保護(hù)因素,血清FA水平對(duì)胎兒CHD的發(fā)生有預(yù)測(cè)價(jià)值。
[Abstract]:Objective to investigate the changes of serum folate (FA) and homocysteine (Hcy) levels in pregnant women and their relationship with fetal congenital heart disease (CHD). Methods 46 pregnant women with fetal CHD were selected as case group and 43 pregnant women without fetal CHD as control group. The levels of serum FA and Hcy were measured by competition law and enzymatic method respectively. The differences of FA and Hcy levels between the two groups were compared. Univariate and multivariate Logistic regression analysis was used to analyze the correlation among the indexes. Results the FA level in the case group was lower than that in the control group (2.426p 0.017), and the Hcy level in the case group was higher than that in the control group, but the difference was not statistically significant (P 0.05). High body mass and low serum FA level are the risk factors of fetal CHD. The incidence of fetal CHD in pregnant women with FA 鈮，

本文編號(hào)：1961672