本文選題：妊娠期高血壓疾病 + 食欲素　； 參考：《廣東醫(yī)學(xué)》2017年S1期

【摘要】：目的探討妊娠期高血壓疾病(HDP)對(duì)新生兒臍血食欲素、白細(xì)胞介素(IL)-12、IL-10水平的影響及食欲素與IL-12、IL-10的關(guān)系。方法 HDP母親所生新生兒65例,按HDP診斷標(biāo)準(zhǔn)分為3組:HDP 1組24例、HDP 2組23例、HDP 3組18例,選擇同期、健康孕母所生的健康新生兒41例為健康對(duì)照組。采用放射免疫分析法測(cè)定臍血食欲素水平,采用酶聯(lián)免疫吸附法(ELISA)測(cè)定臍血IL-12、IL-10的水平,并分析食欲素與IL-12、IL-10的相關(guān)性。結(jié)果 (1)HDP各組新生兒食欲素水平均高于健康對(duì)照組,隨母親妊娠期高血壓疾病程度的加重逐漸升高,組間比較差異有統(tǒng)計(jì)學(xué)意義(P0.05)。(2)HDP各組新生兒IL-12水平均高于健康對(duì)照組,隨母親妊娠期高血壓疾病程度的加重逐漸升高,組間比較差異有統(tǒng)計(jì)學(xué)意義(P0.05);(3)HDP各組新生兒IL-10水平均低于健康對(duì)照組,隨母親妊娠期高血壓疾病程度的加重呈逐漸降低,組間比較差異有統(tǒng)計(jì)學(xué)意義(P0.05)。(4)HDP組新生兒臍血食欲素水平與IL-12水平呈正相關(guān),與IL-10水平呈負(fù)相關(guān)(r=0.316、P0.05;r=-0.289,P0.05)。結(jié)論 HDP影響了胎兒內(nèi)分泌代謝,且引起胎兒體內(nèi)炎癥因子調(diào)節(jié)紊亂,其影響程度與HDP的臨床進(jìn)程有一定的關(guān)系;食欲素與IL-12、IL-10具有相關(guān)性,提示食欲素與IL-12、IL-10可能共同參與HDP對(duì)胎兒影響的調(diào)節(jié)。
[Abstract]:Objective to investigate the effect of HDP on the levels of Interleukin-12 (IL-10) and Interleukin-12 (IL-10) in umbilical cord blood of neonates and the relationship between appetite and IL-12 IL-10. Methods Sixty-five newborns born to HDP mothers were divided into 3 groups according to the diagnostic criteria of HDP. There were 24 cases in group 1 and 23 cases in group 2. There were 18 cases in group 3. 41 healthy newborns born from healthy pregnant women were selected as healthy control group. The levels of Interleukin-10 (IL-12) in umbilical cord blood were measured by radioimmunoassay, and the levels of IL-12 IL-10 in cord blood were determined by enzyme linked immunosorbent assay (Elisa), and the correlation between orexin and IL-12 IL-10 was analyzed. Results the levels of appetite in newborns in each group were higher than those in healthy control group, and gradually increased with the aggravation of the degree of hypertension complicating pregnancy. The IL-12 levels of newborns in each group were significantly higher than those in healthy control group. With the aggravation of the degree of hypertension complicating pregnancy, the levels of IL-10 in the newborns of each group were lower than those in the healthy control group, and decreased gradually with the aggravation of the degree of hypertension disorder complicating pregnancy. There was a significant difference between the two groups. There was a positive correlation between the level of appetite in umbilical cord blood and the level of IL-12, and a negative correlation with the level of IL-10. Conclusion HDP affects the endocrine metabolism of the fetus and causes the disturbance of the regulation of inflammatory cytokines in the fetus, which is related to the clinical process of HDP, and the relationship between orexin and IL-12 / IL-10. These results suggest that appetite and IL-12 IL-10 may be involved in the regulation of fetal HDP.
【作者單位】： 石家莊市第五醫(yī)院兒科;河北醫(yī)科大學(xué)第一附屬醫(yī)院兒科;
【分類(lèi)號(hào)】：R714.246

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