發(fā)布時(shí)間：2018-04-17 16:15

  本文選題：乙型肝炎 + 拉米夫定��； 參考：《中國(guó)全科醫(yī)學(xué)》2017年S1期

【摘要】：目的探討拉米夫定、乙型肝炎疫苗、免疫球蛋白三者聯(lián)合阻斷乙型肝炎母嬰傳播的臨床效果。方法選取2012年1月—2016年1月松陽(yáng)縣人民醫(yī)院妊娠合并乙型肝炎的患者共60例,根據(jù)治療方法分為拉米夫定、乙型肝炎疫苗、免疫球蛋白的三聯(lián)組和乙型肝炎疫苗、免疫球蛋白的二聯(lián)組,比較兩組患者分娩前后的乙型肝炎病毒(HBV)-DNA水平、兩組嬰兒的一般資料及分娩后12個(gè)月的HBV-DNA、乙型肝炎表面抗體(HBsAb)及乙型肝炎表面抗原(HBsAg)陽(yáng)性率。結(jié)果分娩前三聯(lián)組的丙氨酸氨基轉(zhuǎn)移酶(ALT)和HBV-DNA載量低于治療前,且低于二聯(lián)組,差異有統(tǒng)計(jì)學(xué)意義(P0.05),三聯(lián)組的阻斷率高于二聯(lián)組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。三聯(lián)組和二聯(lián)組的身長(zhǎng)、頭圍、體質(zhì)量、新生兒Apgar評(píng)分和出現(xiàn)新生兒窒息的比例比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論拉米夫定、乙型肝炎疫苗、免疫球蛋白三者聯(lián)合可顯著提高乙型肝炎母嬰傳播的阻斷效果,安全性良好,效果優(yōu)于聯(lián)合應(yīng)用乙型肝炎疫苗和免疫球蛋白。
[Abstract]:Objective to investigate the clinical effect of lamivudine, hepatitis B vaccine and immunoglobulin on blocking mother-to-child transmission of hepatitis B.Methods A total of 60 pregnant women with hepatitis B in Songyang County people's Hospital from January 2012 to January 2016 were divided into lamivudine, hepatitis B vaccine, immunoglobulin triple group and hepatitis B vaccine.The HBV-DNA levels before and after delivery, the general data of infants in the two groups, and the positive rates of HBV-DNA, HBV-DNA (HBV-DNA) and HBsAg (HBsAg) were compared between the two groups before and after delivery.Results the levels of alanine aminotransferase (alt) and HBV-DNA in the three groups before delivery were lower than those before treatment and lower than those in the two groups. The difference was statistically significant (P 0.05). The blocking rate of the three groups was higher than that of the two groups (P 0.05).There was no significant difference in body length, head circumference, body mass, neonatal Apgar score and the proportion of neonatal asphyxia between the three groups and the two groups (P 0.05).Conclusion the combination of lamivudine, hepatitis B vaccine and immunoglobulin can significantly improve the blocking effect of mother-to-child transmission of hepatitis B. the efficacy is better than that of combined application of hepatitis B vaccine and immunoglobulin.
【作者單位】： 浙江省麗水市松陽(yáng)縣人民醫(yī)院;
【分類號(hào)】：R714.251
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本文編號(hào)：1764328