發(fā)布時間：2018-04-17 18:00

  本文選題：輸卵管妊娠 + 糖類抗原��； 參考：《上海交通大學學報(醫(yī)學版)》2015年03期

【摘要】：目的分析輸卵管妊娠患者腹腔血與靜脈血清中糖類抗原125(CA125)、β-人絨毛膜促性腺素(β-h CG)、孕酮(P)、肌酸激酶(CK)和血管內(nèi)皮生長因子(VEGF)含量及其比值,分析各指標與不同類型輸卵管妊娠間的關(guān)系,尋找早期診斷輸卵管妊娠破裂的生化標志物。方法測定322例輸卵管妊娠患者靜脈血清及腹腔血中CA125、β-h CG、P、CK和VEGF的含量,計算腹腔血與靜脈血清中各標志物的比值(Rv/p),繪制受試者工作特征曲線(ROC曲線)并確定各項值診斷輸卵管妊娠破裂型的最佳界值,評價其診斷輸卵管妊娠破裂的靈敏度和特異度。結(jié)果 1CA125v、β-h CGv、Pv、CKv、VEGFv診斷輸卵管妊娠破裂型的ROC曲線下面積(AUCROC)分別為0.528、0.674、0.570、0.643和0.542。2CA125p、β-h CGp、Pp、CKp、VEGFp診斷輸卵管妊娠破裂型的AUCROC分別為0.896、0.595、0.656、0.586和0.682。3Rv/p-CA125、Rv/p-(β-h CG)、Rv/p-P、Rv/p-CK和Rv/p-VEGF診斷輸卵管妊娠破裂型的AUCROC分別為0.883、0.757、0.607、0.628和0.598。4當CA125p400.15 U/m L時,其診斷輸卵管妊娠破裂的靈敏度為73.68%,特異度達92.83%。5當Rv/pCA12515.20時,其診斷輸卵管妊娠破裂的靈敏度和特異度分別為73.68%和89.81%。結(jié)論當CA125p400.15 U/m L或Rv/p-CA12515.20時可診斷為輸卵管妊娠破裂型,而CA125p400.15 U/m L的特異度更高。
[Abstract]:Objective to analyze the contents and ratio of serum carbohydrate antigen 125 (CA125), 尾 -human chorionic gonadotropin (尾 -h CGN), progesterone (PRP), creatine kinase (CK) and vascular endothelial growth factor (VEGF) in serum of patients with tubal pregnancy.In order to find the biochemical markers for early diagnosis of tubal pregnancy rupture, the relationship between each index and different types of tubal pregnancy was analyzed.Methods the contents of CA125, 尾 -h CGTP-CK and VEGF in plasma of 322 patients with tubal pregnancy were measured.The ratio of serum markers in peritoneal blood and vein was calculated, and the operating characteristic curve and ROC curve were plotted. The best boundary value for diagnosis of tubal pregnancy rupture type was determined, and the sensitivity and specificity of diagnosis of tubal pregnancy rupture were evaluated.緇撴灉 1CA125v,尾-h CGv,Pv,CKv,VEGFv璇婃柇杈撳嵉綆″濞犵牬瑁傚瀷鐨凴OC鏇茬嚎涓嬮潰縐，

本文編號：1764665