發(fā)布時(shí)間：2018-03-31 09:49

  本文選題：Toll樣受體　切入點(diǎn)：Toll樣受體信號(hào)通路　出處：《山東醫(yī)藥》2015年43期

【摘要】：目的觀察不同宮頸病變組織中Toll樣受體(TLR)4、TLR9及其信號(hào)通路下游因子NF-κB、IFN-γ基因的表達(dá)變化。方法接受婦科手術(shù)或?qū)m頸活檢術(shù)的患者共90例,根據(jù)手術(shù)或活檢宮頸組織病理檢查結(jié)果分為三組:正常組[高危型人乳頭瘤病毒(HPV)陰性、未見(jiàn)上皮內(nèi)病變]30例,宮頸上皮內(nèi)瘤變(CIN)組(HPV陽(yáng)性、CIN)30例(CINⅠ4例,CINⅡ9例,CINⅢ17例),宮頸癌組(HPV陽(yáng)性、宮頸癌)30例(病理分期ⅠA~ⅡA期12例、ⅡB~Ⅳ期18例)。采用實(shí)時(shí)熒光定量PCR法檢測(cè)三組患者宮頸組織中的TLR4、TLR9、NF-κB、IFN-γ基因。結(jié)果TLR4、TLR9、NF-κB、IFN-γ基因在三組患者宮頸組織中均有表達(dá),隨著宮頸病變的進(jìn)展,其表達(dá)量均逐漸上升,組間相比,P均0.05。結(jié)論 TLR4、TLR9及其信號(hào)通路下游因子NF-κB、IFN-γ基因表達(dá)量隨子宮頸病變進(jìn)展呈上升趨勢(shì),TLR4、TLR9及其信號(hào)通路參與并可能促進(jìn)宮頸癌的發(fā)生和發(fā)展。
[Abstract]:Objective to observe the expression of Toll like receptor (TLR) 4 and its downstream factor NF- 魏 B ~ (1) IFN- 緯 in different cervical lesions. Methods 90 patients underwent gynecological or cervical biopsy. According to the pathological results of operation or biopsy of cervix, the patients were divided into three groups: 30 cases in normal group [HPV-negative, no intraepithelial lesion]. In the cervical intraepithelial neoplasia (cin) group, there were 30 cases of cin 鈪，

本文編號(hào)：1690203