本文選題：高純度人絕經(jīng)促性腺激素　切入點：重組FSH　出處：《生殖醫(yī)學(xué)雜志》2016年12期 　論文類型：期刊論文

【摘要】：目的探討高純度人絕經(jīng)期促性腺激素(HP-HMG)在體外受精-胚胎移植(IVF-ET)促排卵治療中的有效使用方法。方法回顧性分析2013年1月5日至10月30日于中信湘雅生殖與遺傳�？漆t(yī)院行IVF-ET助孕的298名患者的臨床資料,根據(jù)促排卵藥物的不同分成2組:單純使用HP-HMG的138人為第1組,使用重組FSH(rFSH)和HP-HMG的160人為第2組。比較兩組患者促排卵過程中卵巢反應(yīng)、激素水平、用藥情況及治療結(jié)局。結(jié)果第2組Gn第6天的E2水平[(2 923.06±430.64)pmol/L]顯著高于第1組[(2 218.44±1 745.86)pmol/L](P0.05)。第1組HCG日及Gn第6天HCG水平、總Gn用量和Gn天數(shù)明顯高于第2組[(分別為(1.79±0.78)U/L vs.(0.89±0.59)U/L,(1.38±1.03)U/L vs.(0.48±0.35)U/L,(1 623.02±547.08)U vs.(1 287.53±498.58)U,(9.89±1.57)d vs.(9.35±1.48)d](P0.05)。兩組患者的平均獲卵數(shù)、受精數(shù)、優(yōu)胚數(shù)、早期流產(chǎn)率、取消率、中重度卵巢過度刺激綜合征(OHSS)發(fā)生率、OHSS取消率、宮外孕發(fā)生率比較均無顯著性差異(P0.05)。第2組患者的妊娠率、著床率和活產(chǎn)率顯著高于第1組(分別為81.06%vs.67.29%,62.25%vs.46.60%,74.24%vs.59.81%)(P0.05)。結(jié)論在IVF-ET治療中,使用rFSH和HP-HMG聯(lián)合促排卵可以獲得比單純應(yīng)用HP-HMG較高的臨床妊娠率。
[Abstract]:Objective to investigate the effective use of high purity human menopausal gonadotropin (HP-HMG) in the treatment of ovulation promotion by IVF-ET.Methods the reproductive and genetic characteristics of Citic Xiangya from January 5th 2013 to October 30th were retrospectively analyzed. The clinical data of 298 patients who received IVF-ET for pregnancy, According to the different ovulation drugs, the patients were divided into two groups: the first group was treated with HP-HMG alone, the second group was treated with recombinant FSHrFSHs and the second group was treated with HP-HMG. The ovarian response and hormone levels during ovulation induction were compared between the two groups. Results the level of E2 on the 6th day of Gn in group 2 was significantly higher than that in group 1 [2218.44 鹵1 745.86 pmol / L] on the 6th day of Gn, and the level of HCG in group 1 was significantly higher than that in group 1 on day 6 of HCG and G _ n on day 6, and the level of E _ 2 in group 2 was significantly higher than that in group 1 [2 218.44 鹵1 745.86 pmol / L]. The total dosage of Gn and the days of Gn were significantly higher than those of the second group [(1.79 鹵0.78 UL vs.(0.89 鹵0.59 UL vs.(0.89 鹵0.59 U / L, respectively 1.38 鹵1.03U / L vs.(0.48 鹵0.35U / L 鹵0.35U / L) 1.623.02 鹵547.08U vs.(1 287.53 鹵498.58U9.89 鹵1.57U / d vs.(9.35 鹵1.48d] P0.05. The average number of eggs, the number of fertilized embryos, the number of excellent embryos, the early abortion rate, the cancellation rate, the rate of cancellations of OHSS were measured. There was no significant difference in the incidence of ectopic pregnancy (P 0.05). The pregnancy rate, implantation rate and live birth rate in group 2 were significantly higher than those in group 1 (81.06vs.67.29vs.46.60g. 74.24vs.59.81P0.050.Conclusion in the treatment of IVF-ET, the pregnancy rate, the implantation rate and the live delivery rate were significantly higher than those in the first group (81.06vs.67.29vs.46.60g / 74.24vs.59.81.Conclusion in the treatment of IVF-ET, The combination of rFSH and HP-HMG can obtain a higher clinical pregnancy rate than that with HP-HMG alone.
【作者單位】： 中南大學(xué)生殖與干細(xì)胞工程研究所;中信湘雅生殖與遺傳專科醫(yī)院;
【分類號】：R714.8

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