發(fā)布時(shí)間：2018-02-10 00:15

  本文關(guān)鍵詞： 閉經(jīng) 染色體核型 遺傳學(xué)分析 性腺發(fā)育不良 先天畸形　出處：《中國婦產(chǎn)科臨床雜志》2015年04期 　論文類型：期刊論文

【摘要】：目的探討外周血細(xì)胞染色體檢查在閉經(jīng)患者診斷中的臨床意義。方法回顧性分析1990年1月至2013年1月山西醫(yī)科大學(xué)第一臨床醫(yī)院進(jìn)行外周血淋巴細(xì)胞染色體檢查的455例閉經(jīng)患者的臨床資料,并分為原發(fā)性閉經(jīng)組與繼發(fā)性閉經(jīng)組,比較兩組患者染色體檢查結(jié)果及臨床特點(diǎn)。結(jié)果在455例患者中,染色體異常104例(22.86%),其中原發(fā)性閉經(jīng)患者染色體異常率為24.59%(89/362);繼發(fā)性閉經(jīng)患者為16.13%(15/93)。原發(fā)性閉經(jīng)組中先天性無子宮和(或)無陰道患者156例,其中染色體正常124例,異常32例。原發(fā)性閉經(jīng)合并內(nèi)分泌異常者占20.17%(73/362),繼發(fā)性閉經(jīng)合并內(nèi)分泌異常占68.82%(64/93)。104例染色體異常患者中,含Y染色體者占30.77%(32/104),X染色體數(shù)目異常占46.15%(48/104),X染色體結(jié)構(gòu)異常占19.23%(20/104),常染色體異常占3.85%(4/104)。結(jié)論染色體異常是導(dǎo)致閉經(jīng)的主要原因,不僅重視原發(fā)閉經(jīng)患者的染色體檢查,繼發(fā)閉經(jīng)患者也不容忽視。
[Abstract]:Objective to investigate the clinical significance of peripheral blood cell chromosome examination in the diagnosis of amenorrhea. Methods from January 1990 to January 2013, the chromosome examination of peripheral blood lymphocytes was performed in the first Clinical Hospital of Shanxi Medical University. Clinical data of 455 patients with amenorrhea, It was divided into primary amenorrhea group and secondary amenorrhea group. The results of chromosome examination and clinical features were compared between the two groups. There were 104 cases of chromosomal abnormalities, of which the rate of chromosomal abnormalities in primary amenorrhea was 24.5989 / 362g; in secondary amenorrhea, 16.131315 / 93%; in primary amenorrhea, 156 cases were congenital without uterus and / or without vagina, among which 124 cases were normal chromosomes. 32 cases were abnormal. Primary amenorrhea complicated with endocrine abnormality accounted for 20.1773 / 362a, secondary amenorrhea with endocrine abnormality accounted for 68.82n64 / 93n.104 cases with chromosomal abnormality. The number of chromosomes with Y chromosomes is 30.7777 / 104% and the number of X chromosomes is abnormal, accounting for 46.15% and 46.15%. The chromosomal structural abnormalities of 48% 104% X chromosomes account for 19.23% 10 / 104%, and the autosomal abnormalities account for 3.85% 104% .Conclusion chromosomal abnormalities are the main cause of amenorrhea, and not only the chromosome examination of primary amenorrhea patients, Secondary amenorrhea patients should not be ignored.
【作者單位】： 山西醫(yī)科大學(xué)第一臨床醫(yī)學(xué)院婦產(chǎn)科;山西大醫(yī)院婦產(chǎn)科;山西醫(yī)科大學(xué)第一醫(yī)院;
【分類號】：R711.51

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本文編號：1499200