本文關(guān)鍵詞：復(fù)發(fā)性流產(chǎn)合并抗磷脂抗體綜合征診療進(jìn)展　出處：《中國優(yōu)生與遺傳雜志》2016年05期 　論文類型：期刊論文

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【摘要】：抗磷脂抗體綜合征(Antiphospholipid syndrome,APS)是一組由抗磷脂抗體(Antiphospholipid antibodies,APA)介導(dǎo),臨床表現(xiàn)為反復(fù)動、靜脈血栓形成、復(fù)發(fā)性流產(chǎn)等,實驗室血清檢查持續(xù)性抗磷脂抗體陽性為特征的自身免疫性疾病�？沽字贵w綜合征病因涉及廣泛,疾病臨床表現(xiàn)多樣,臨床治療主要以抗凝治療為核心。目前國際上將與同一性伴侶連續(xù)發(fā)生兩次或兩次以上妊娠20w前的妊娠丟失稱為復(fù)發(fā)性流產(chǎn),其中約20%左右由抗磷脂抗體綜合征引起。復(fù)發(fā)性流產(chǎn)為育齡期抗磷脂抗體綜合征女性患者最常見臨床表現(xiàn),反復(fù)清宮治療影響子宮內(nèi)膜及遠(yuǎn)期妊娠,對育齡期女性身心造成負(fù)面影響�？沽字贵w綜合征可造成嚴(yán)重產(chǎn)科并發(fā)癥。因此,適當(dāng)、適時治療對于改善妊娠結(jié)局、提高女性生殖健康意義重大。目前雖然抗凝及免疫抑制及調(diào)節(jié)治療可有效提高患者成功分娩率,但尚無標(biāo)準(zhǔn)化治療規(guī)范。新的治療方式正在不斷探索中。本文綜述了復(fù)發(fā)性流產(chǎn)合并抗磷脂抗體綜合征的發(fā)病機制、疾病診斷及治療情況,旨在為疾病的診斷和治療提供參考及借鑒。
[Abstract]:Antiphospholipid syndrome of anti-phospholipid antibody syndrome. APS) is a group of antiphospholipid antibodies-mediated by antiphospholipid APA, clinical manifestations of recurrent arteriovenous thrombosis. Recurrent abortion and other autoimmune diseases characterized by persistent positive anti-phospholipid antibody in laboratory serum. The etiology of anti-phospholipid antibody syndrome is extensive and the clinical manifestations of the disease are diverse. Clinical treatment is mainly based on anticoagulant therapy. At present, two consecutive pregnancies with the same partner or more than two pregnancies before 20 weeks of pregnancy loss is called recurrent abortion. Recurrent abortion is the most common clinical manifestation of female patients with antiphospholipid antibody syndrome in childbearing age. Anti-phospholipid antibody syndrome can cause severe obstetric complications. Therefore, appropriate and timely treatment can improve the outcome of pregnancy. It is of great significance to improve the reproductive health of women. Although anticoagulant and immunosuppressive and regulatory therapy can effectively improve the rate of successful delivery of patients. However, there is no standardized treatment standard. New treatment methods are being explored. This article reviews the pathogenesis, disease diagnosis and treatment of recurrent abortion with anti-phospholipid antibody syndrome. The aim is to provide reference for diagnosis and treatment of disease.
【作者單位】： 北京大學(xué)第三醫(yī)院婦產(chǎn)科生殖醫(yī)學(xué)中心教育部輔助生殖重點實驗室北京市內(nèi)分泌與輔助生殖重點實驗室;
【分類號】：R714.21
【正文快照】： 抗磷脂抗體綜合征是以全身動、靜脈血栓形成為主要表現(xiàn)的自身免疫性疾病,疾病表現(xiàn)涉及全身多系統(tǒng)。目前我國男女患病率之比約為1∶9[1],育齡期女性多因反復(fù)出現(xiàn)妊娠丟失現(xiàn)象,于就診過程中首次發(fā)現(xiàn)。目前國際上將與同一性伴侶連續(xù)兩次或者兩次以上出現(xiàn)妊娠20周前的妊娠丟失稱為

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