【摘要】：目的研究癲癇患兒海馬急性損傷的MRI表現(xiàn),探討其發(fā)病原因及轉(zhuǎn)歸,提高對(duì)海馬急性損傷結(jié)構(gòu)改變的認(rèn)識(shí)。資料與方法回顧性分析經(jīng)頭顱MRI檢查擴(kuò)散加權(quán)成像(DWI)海馬表現(xiàn)為高信號(hào)的8例癲癇患兒的臨床及影像學(xué)資料,測(cè)量雙側(cè)海馬體積及表觀擴(kuò)散系數(shù)(ADC)值,分析海馬體積、T2WI信號(hào)變化及ADC值改變。結(jié)果 8例臨床診斷為癲癇,其中7例有反復(fù)癲癇發(fā)作史。MRI檢查距癲癇發(fā)作時(shí)間1~5 d。8例均為單側(cè)海馬體積增大,其中左側(cè)6例,右側(cè)2例,患側(cè)海馬體積為(2.096±0.570)cm3,顯著大于健側(cè)(1.768±0.447)cm3(t=-4.763,P0.01)。T2WI及FLAIR信號(hào)增高;DWI顯示高信號(hào),增高約25.52%�；紓�(cè)ADC值為(0.763±0.049)×10-3 mm2/s,較健側(cè)(0.859±0.054)×10-3 mm2/s降低(t=9.598,P0.01)。3例此次發(fā)作前曾由于熱性驚厥或抽搐發(fā)作行MRI檢查,雙側(cè)海馬未見(jiàn)異常。3例3~5個(gè)月后復(fù)查,患側(cè)海馬體積縮小;T2WI及FLAIR信號(hào)仍較高;ADC值增高15.6%,表現(xiàn)為海馬硬化。結(jié)論癲癇可以引起海馬急性損傷,表現(xiàn)為海馬腫大,T2WI信號(hào)增加,ADC值下降;海馬急性損傷發(fā)展為海馬硬化。
[Abstract]:Objective to study the MRI findings of acute hippocampal injury in children with epilepsy, to explore the cause and outcome of acute hippocampal injury, and to improve the understanding of structural changes of acute hippocampal injury. Materials and methods the clinical and imaging data of 8 epileptic children with high signal intensity on (DWI) were analyzed retrospectively. the bilateral hippocampal volume and apparent diffusion coefficient (ADC) were measured, and the hippocampal volume, T2WI signal changes and ADC values were analyzed. Results Epilepsy was diagnosed in 8 cases, and 7 cases had a history of recurrent seizures. MRI showed unilateral hippocampal volume enlargement in 8 cases, including 6 cases on the left side and 2 cases on the right side. The hippocampal volume of the affected side was (2.096 鹵0.570) cm3, which was significantly higher than that of the healthy side (1.768 鹵0.447) cm3 (t 鈮，

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