吸煙和飲咖啡對(duì)局部腦血流量短期影響的動(dòng)脈自旋標(biāo)記研究
發(fā)布時(shí)間：2019-06-27 09:07
【摘要】：目的探討吸煙對(duì)正常成年人局部腦血流量(rCBF)產(chǎn)生的短期影響。材料與方法41名青中年健康志愿者(年齡22~55歲,平均年齡36.6±11.8歲)進(jìn)行吸煙試驗(yàn),并分為吸煙史組(男21名)和無(wú)吸煙史組(男20名),采用3D-ASL磁共振灌注技術(shù)定量測(cè)量41名志愿者吸煙前后枕葉、額葉、顳葉灰質(zhì)和丘腦、基底節(jié)區(qū)rCBF。結(jié)果(1)41名志愿者吸煙前后的各腦區(qū)rCBF無(wú)明顯統(tǒng)計(jì)學(xué)差異(P值均0.05)。(2)21名吸煙史組的吸煙前rCBF低于20名無(wú)吸煙史組,且在雙側(cè)枕葉、顳葉、丘腦以及左側(cè)基底節(jié)區(qū)的rCBF差別較大(P值均0.05)。結(jié)論基于3D-ASL技術(shù)檢測(cè)吸煙對(duì)局部腦灰質(zhì)血流量的短期影響,吸煙對(duì)rCBF并未產(chǎn)生短期影響,而長(zhǎng)期吸煙能導(dǎo)致rCBF降低。目的探討飲咖啡對(duì)正常成年人局部腦血流量(rCBF)產(chǎn)生的短期影響。材料與方法19名青年健康志愿者(年齡范圍22~27歲,平均年齡24.4±1.4歲)進(jìn)行咖啡試驗(yàn),采用3D-ASL磁共振灌注技術(shù)定量測(cè)量19名志愿者飲用咖啡前后枕葉、額葉、顳葉灰質(zhì)和丘腦、基底節(jié)區(qū)rCBF。結(jié)果19名志愿者飲用咖啡后,雙側(cè)枕葉、額葉、顳葉灰質(zhì)和丘腦、基底節(jié)的rCBF均產(chǎn)生明顯降低的急性變化(P值均0.05),且其下降幅度分別為14.5%(右)、16.5%(左)、11.6%(右)、11.7%(左)、17.6%(右)、15.7%(左)、14.0%(右)、14.3%(左)、14.4%(右)、15.4%(左),以右側(cè)顳葉變化最為顯著。結(jié)論基于3D-ASL技術(shù)檢測(cè)咖啡對(duì)局部腦灰質(zhì)血流量的短期影響,咖啡使rCBF發(fā)生降低的急性變化。
[Abstract]:Objective to investigate the short-term effect of smoking on regional cerebral blood flow (rCBF) in normal adults. Materials and methods 41 young and middle-aged healthy volunteers (22 years old, 55 years old, mean age 36.6 鹵11.8 years) were divided into smoking history group (21 males) and non-smoking history group (20 males). The occipital lobe, frontolobe, temporal lobe gray matter, thalamus and basal ganglia rCBF. of 41 volunteers before and after smoking were quantitatively measured by 3D-ASL magnetic resonance perfusion technique. Results (1) there was no significant difference in rCBF in each brain area of 41 volunteers before and after smoking (P < 0.05). (2). The rCBF of 21 smoking history groups before smoking was lower than that of 20 non-smoking history groups, and the rCBF in bilateral occipital lobe, temporal lobe, thalamus and left basal ganglia was significantly different (P < 0.05). Conclusion based on 3D-ASL, the short-term effect of smoking on local gray matter blood flow is detected. Smoking has no short-term effect on rCBF, but long-term smoking can lead to the decrease of rCBF. Objective to investigate the short-term effect of coffee drinking on regional cerebral blood flow (rCBF) in normal adults. Materials and methods Coffee test was carried out in 19 young healthy volunteers (age range 22 鈮，
本文編號(hào)：2506665
[Abstract]:Objective to investigate the short-term effect of smoking on regional cerebral blood flow (rCBF) in normal adults. Materials and methods 41 young and middle-aged healthy volunteers (22 years old, 55 years old, mean age 36.6 鹵11.8 years) were divided into smoking history group (21 males) and non-smoking history group (20 males). The occipital lobe, frontolobe, temporal lobe gray matter, thalamus and basal ganglia rCBF. of 41 volunteers before and after smoking were quantitatively measured by 3D-ASL magnetic resonance perfusion technique. Results (1) there was no significant difference in rCBF in each brain area of 41 volunteers before and after smoking (P < 0.05). (2). The rCBF of 21 smoking history groups before smoking was lower than that of 20 non-smoking history groups, and the rCBF in bilateral occipital lobe, temporal lobe, thalamus and left basal ganglia was significantly different (P < 0.05). Conclusion based on 3D-ASL, the short-term effect of smoking on local gray matter blood flow is detected. Smoking has no short-term effect on rCBF, but long-term smoking can lead to the decrease of rCBF. Objective to investigate the short-term effect of coffee drinking on regional cerebral blood flow (rCBF) in normal adults. Materials and methods Coffee test was carried out in 19 young healthy volunteers (age range 22 鈮，
本文編號(hào)：2506665
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