分子探針Tf-SPION在肝癌早期磁共振成像及同步治療中的應(yīng)用
發(fā)布時間：2019-06-04 10:12
【摘要】：目的探討分子探針Tf-SPION在肝癌早期磁共振(MR)成像及同步治療中的應(yīng)用價值。方法選擇40只雄性SD大鼠中的20只隨機分為A組與B組各10只,A組經(jīng)尾靜脈注入生理鹽水5 mg/kg;B組經(jīng)尾靜脈注入Tf-SPION 5 mg/kg。剩余20只大鼠建立肝癌模型,造模成功隨機分為C組與D組各10只,然后進(jìn)行同步治療,C組經(jīng)肝動脈注射生理鹽水5 mg/kg,D組經(jīng)肝動脈注射Tf-SPION 5 mg/kg。SD大鼠在干預(yù)后1、4、24 h后分別行腹部磁共振T2橫斷位掃描,并且計算腫瘤的T2相對信號強度比(RR)。在干預(yù)后1、24 h后取病理標(biāo)本進(jìn)行普魯士藍(lán)染色。結(jié)果A組與C組在注射生理鹽水前后的腫瘤T2 RR無明顯差異(P0.05),且組間對比差異也無統(tǒng)計學(xué)意義(P0.05)。B組在經(jīng)尾靜脈注入Tf-SPION后T2 RR值有稍微波動,但是無明顯差異(P0.05)。D組在經(jīng)肝動脈注射Tf-SPION后腫瘤T2 RR值明顯下降(P0.05)。A組腫瘤細(xì)胞內(nèi)均沒有藍(lán)染鐵粒子,D組在干預(yù)后1、24 h的鐵粒子含量明顯高于B組,C組在干預(yù)后第1小時的鐵粒子含量,低于同時間點的B組與D組(P0.05)。結(jié)論靶向成像分子探針Tf-SPION在肝癌早期MR成像與同步治療有很好的高效性與敏感性,可作為一個新途徑來評價肝癌同步治療后療效。
[Abstract]:Objective to evaluate the value of molecular probe Tf-SPION in early magnetic resonance (MR) imaging and synchronous treatment of hepatocellular carcinoma (HCC). Methods 20 of 40 male SD rats were randomly divided into two groups: group A (n = 10) and group B (n = 10). Group A was injected with normal saline 5 mg/kg;B via tail vein and Tf-SPION 5 mg/kg. was injected through tail vein. The remaining 20 rats were randomly divided into group C (n = 10) and group D (n = 10). The rats in group C were injected with normal saline 5 mg/kg, via hepatic artery. In group D, Tf-SPION 5 mg/kg.SD rats were injected into hepatic artery at 1, 4 and 24 hours after intervention, and abdominal MRI T2 transection scan was performed 24 hours later, and the T2 relative signal intensity ratio of tumor to (RR). Was calculated. The pathological specimens were stained with Prussian blue 24 hours after intervention. Results there was no significant difference in T2 RR between group A and group C before and after injection of saline (P 0.05), and there was no significant difference between groups (P 0.05). There was no significant difference in T2 RR between group A and group C before and after injection of normal saline (P 0.05). There was no significant difference in T2 RR between group A and group C (P 0.05). However, there was no significant difference (P < 0.05). The T2 RR value of tumor in). D group decreased significantly after Tf-SPION injection through hepatic artery (P 0.05). There were no blue iron particles in tumor cells in). A group (P 0.05). The content of iron particles in group D was significantly higher than that in group B at 24 hours after intervention, and the content of iron particles in group C at the first hour after intervention was lower than that in group B and group D at the same time point (P 0.05). Conclusion targeted imaging molecular probe Tf-SPION is highly effective and sensitive in early MR imaging and synchronous treatment of liver cancer, and can be used as a new way to evaluate the curative effect of synchronous treatment of liver cancer.
【作者單位】： 湖北醫(yī)藥學(xué)院附屬東風(fēng)醫(yī)院磁共振室;
【分類號】：R445.2;R735.7
本文編號：2492654
[Abstract]:Objective to evaluate the value of molecular probe Tf-SPION in early magnetic resonance (MR) imaging and synchronous treatment of hepatocellular carcinoma (HCC). Methods 20 of 40 male SD rats were randomly divided into two groups: group A (n = 10) and group B (n = 10). Group A was injected with normal saline 5 mg/kg;B via tail vein and Tf-SPION 5 mg/kg. was injected through tail vein. The remaining 20 rats were randomly divided into group C (n = 10) and group D (n = 10). The rats in group C were injected with normal saline 5 mg/kg, via hepatic artery. In group D, Tf-SPION 5 mg/kg.SD rats were injected into hepatic artery at 1, 4 and 24 hours after intervention, and abdominal MRI T2 transection scan was performed 24 hours later, and the T2 relative signal intensity ratio of tumor to (RR). Was calculated. The pathological specimens were stained with Prussian blue 24 hours after intervention. Results there was no significant difference in T2 RR between group A and group C before and after injection of saline (P 0.05), and there was no significant difference between groups (P 0.05). There was no significant difference in T2 RR between group A and group C before and after injection of normal saline (P 0.05). There was no significant difference in T2 RR between group A and group C (P 0.05). However, there was no significant difference (P < 0.05). The T2 RR value of tumor in). D group decreased significantly after Tf-SPION injection through hepatic artery (P 0.05). There were no blue iron particles in tumor cells in). A group (P 0.05). The content of iron particles in group D was significantly higher than that in group B at 24 hours after intervention, and the content of iron particles in group C at the first hour after intervention was lower than that in group B and group D at the same time point (P 0.05). Conclusion targeted imaging molecular probe Tf-SPION is highly effective and sensitive in early MR imaging and synchronous treatment of liver cancer, and can be used as a new way to evaluate the curative effect of synchronous treatment of liver cancer.
【作者單位】： 湖北醫(yī)藥學(xué)院附屬東風(fēng)醫(yī)院磁共振室;
【分類號】：R445.2;R735.7
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