發(fā)布時(shí)間：2019-02-18 18:31

【摘要】：本文結(jié)合國(guó)家自然基金項(xiàng)目和天津市支撐重大項(xiàng)目,對(duì)圖像導(dǎo)航近距離粒子放療手術(shù)中的劑量規(guī)劃計(jì)算方法、劑量可視化方法、劑量?jī)?yōu)化方法等關(guān)鍵技術(shù)進(jìn)行研究,提出了三維適形劑量規(guī)劃方法,并開(kāi)發(fā)了三維近距離粒子植入治療計(jì)劃系統(tǒng),最后通過(guò)實(shí)驗(yàn)與蒙特卡羅模擬驗(yàn)證了劑量計(jì)算精度。本文的主要研究?jī)?nèi)容及成果如下:首先,采用TG-43線源劑量模型,繪制了單顆粒子的劑量分布曲線。采用標(biāo)量線性疊加算法,實(shí)現(xiàn)了空間中多顆粒子的劑量分布計(jì)算。由放射性衰變規(guī)律,推導(dǎo)了劑量吸收量的計(jì)算方法。其次,針對(duì)放射性粒子植入放療,提出了其三維適形劑量規(guī)劃方法。通過(guò)對(duì)劑量進(jìn)行優(yōu)化,避免了局部劑量盲區(qū)和正常組織的過(guò)量照射。在此基礎(chǔ)上,開(kāi)發(fā)了三維近距離粒子植入治療計(jì)劃系統(tǒng),改進(jìn)了劑量體積直方圖的繪制算法,提高繪制的精確度。最后,設(shè)計(jì)開(kāi)發(fā)了I-125放射性粒子載體裝置,搭建了粒子劑量分布實(shí)驗(yàn)平臺(tái),進(jìn)行了單粒子和多粒子劑量分布實(shí)驗(yàn)。通過(guò)與蒙特卡羅方法數(shù)值模擬結(jié)果和治療計(jì)劃系統(tǒng)輸出結(jié)果對(duì)比,驗(yàn)證了治療計(jì)劃系統(tǒng)中劑量計(jì)算的精確性。
[Abstract]:In this paper, the key techniques such as dose planning, dose visualization, dose optimization, and so on, are studied in combination with the National Natural Fund project and the important projects in Tianjin, such as image navigation, brachyparticle radiotherapy, and so on. A three dimensional conformal dose planning method is proposed and a three dimensional near distance particle implantation treatment planning system is developed. Finally, the accuracy of dose calculation is verified by experiments and Monte Carlo simulations. The main contents and achievements of this paper are as follows: firstly, the dose distribution curve of single particle is drawn by using the TG-43 line source dose model. The scalar linear superposition algorithm is used to calculate the dose distribution of multiple particles in space. According to the law of radioactive decay, the calculation method of dose absorption is deduced. Secondly, a three-dimensional conformal dose planning method is proposed for radioactive particle implantation radiotherapy. By optimizing the dose, the local dose blind area and the overdose of normal tissue were avoided. On this basis, a treatment planning system for three dimensional close-range particle implantation is developed, and the algorithm of dose volume histogram is improved to improve the accuracy of the rendering. Finally, the device of I-125 radioactive particle carrier is designed and developed, the experimental platform of particle dose distribution is set up, and the single-particle and multi-particle dose distribution experiments are carried out. The accuracy of dose calculation in the treatment planning system is verified by comparing the numerical simulation results with the Monte Carlo method and the output results of the treatment plan system.
【學(xué)位授予單位】：天津大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R730.55

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