【摘要】：目的應(yīng)用超聲血流向量成像(VFM)技術(shù)可視量化評價急性心肌缺血比格犬舒張期左心室血流的能量損耗變化。方法分別對10只比格犬開胸模型基礎(chǔ)和急性缺血狀態(tài)行VFM檢查,存圖后導(dǎo)入血流向量標(biāo)測軟件分析獲得等容舒張期(T1)、舒張早期(T2)、舒張早期快速充盈(T3)、舒張中期(T4)、舒張晚期心房收縮期(T5)、舒張晚期快速充盈期(T6)左心室整體和基底、中間、心尖水平能量損耗,以及渦旋面積、渦旋循環(huán)強度。定性觀察并比較兩種狀態(tài)下結(jié)果。將缺血狀態(tài)左心室整體能量損耗與渦旋面積、循環(huán)強度進行相關(guān)分析。結(jié)果缺血狀態(tài)下舒張期各時相血流的運動方向相對不規(guī)則,出現(xiàn)典型的湍流及渦旋的波動,能量損耗的分布區(qū)域大且相對離散。與基礎(chǔ)狀態(tài)相比,缺血狀態(tài)下左心室整體能量損耗均增高,其中在T1、T4、T5、T6,差異有統(tǒng)計學(xué)意義(P均0.05)。同樣,缺血狀態(tài)左心室基底、中間水平能量損耗在T1、T4、T5、T6較基礎(chǔ)狀態(tài)增高(P均0.05),缺血狀態(tài)左心室心尖水平能量損耗在T1、T6上較基礎(chǔ)狀態(tài)增高(P均0.05)。在T4、T5、T6,缺血狀態(tài)下渦旋面積及循環(huán)強度均較基礎(chǔ)狀態(tài)增高(P均0.05),且其分別與左心室整體能量損耗顯著相關(guān)(r分別為0.61、0.71、0.55和0.79、0.83、0.65,P0.05)。結(jié)論急性心肌缺血誘導(dǎo)產(chǎn)生左心室血流湍流和異常的渦旋狀態(tài),導(dǎo)致舒張期流體能量損耗的增高,超聲血流能量損耗參數(shù)能夠敏感地反映缺血狀態(tài)左心室血流動力學(xué)的改變。
[Abstract]:Objective to evaluate the energy loss of left ventricular flow in acute myocardial ischemia Beagle canine during diastolic phase by using ultrasound flow vector imaging (VFM). Methods VFM was performed on 10 Beagle dogs with thoracotomy and acute ischemia respectively. The isovolumic diastolic phase (T1), early diastolic phase (T2) and early diastolic rapid filling (T3) were obtained by using flow vector mapping software. Middiastolic (T _ 4), late diastolic atrial contraction (T _ 5), late diastolic rapid filling (T _ 6) left ventricular global and basal, intermediate, apical energy loss, and vortex area, vortex circulation intensity. The results were observed and compared qualitatively. The energy loss of left ventricle was correlated with vortex area and circulation intensity in ischemic state. Results the movement direction of blood flow during diastolic phase was relatively irregular, typical turbulence and vortex fluctuated, and the distribution of energy loss was large and relatively discrete. Compared with the basic state, the whole energy loss of the left ventricle was increased in ischemic state, and the difference was statistically significant in T1T4 and T5T6 (all P 0.05). Similarly, the energy loss at the intermediate level in the left ventricular basement was significantly higher in the ischemic state than in the basal state (P 0.05), and the energy loss at the left ventricular apex in the ischemic state was higher than that in the basal state (P 0.05), and the energy loss of the left ventricular apex in the ischemic state was higher than that in the basal state. The level of T 6 was higher than that of basic state (P 0.05). The vortex area and circulation intensity in ischemic state were significantly higher than those in basic state (P 0.05), and they were significantly correlated with the overall energy loss of left ventricle (r = 0.61-0.71 鹵0.55, r = 0.79 鹵0.83N 0.65, r = 0.71, P < 0.05). P0.05). Conclusion Acute myocardial ischemia induces turbulence and abnormal vortex of left ventricular blood flow, which leads to the increase of flow energy loss in diastolic phase. The parameters of ultrasonic flow energy loss can sensitively reflect the changes of left ventricular hemodynamics in ischemic state.
【作者單位】： 重慶醫(yī)科大學(xué)超聲影像學(xué)研究所;四川省醫(yī)學(xué)科學(xué)院四川省人民醫(yī)院超聲醫(yī)學(xué)研究所;
【基金】：四川省科研院所科技成果轉(zhuǎn)化基金(11010122)
【分類號】：R542.2;R445.1

【共引文獻】

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