【摘要】：目的探討3.0T MRI化學(xué)交換飽和位移成像技術(shù)(chemical exchange saturation transfer,CEST)對肌酸代謝成像的可行性及相關(guān)影響因素。方法準(zhǔn)備不同濃度肌酸及其代謝產(chǎn)物的體外模型和不同pH值的肌酸及其對照組體外模型。采用3.0T MRI對這兩組模型進(jìn)行CEST成像,通過CEST效應(yīng)及Z譜進(jìn)行量化分析。結(jié)果 3.0T MRI可檢測到不同濃度肌酸之間信號(hào)(±1.8ppm)差異明顯(F=99.08,P0.001),且信號(hào)強(qiáng)度隨著濃度增加而增強(qiáng)(r=0.963,P0.001)。另外,不同pH值環(huán)境CEST效應(yīng)差異明顯(F=5.539,P=0.002),信號(hào)隨pH值下降而逐漸減低(r=0.41,P=0.035)。結(jié)論 3.0T MRI進(jìn)行CEST成像評價(jià)肌酸代謝是可行的,且其CEST效應(yīng)受肌酸濃度及代謝環(huán)境pH值等因素影響。
[Abstract]:Objective to investigate the feasibility and related factors of 3.0T MRI chemical-exchange saturated displacement imaging (chemical exchange saturation transfer,CEST) on creatine metabolism imaging. Methods in vitro models of creatine and its metabolites with different concentrations of creatine and creatine with different pH values were prepared. The CEST imaging of the two groups of models was performed with 3.0T MRI, and the CEST effect and Z spectrum were analyzed quantitatively. Results the signal (鹵1.8ppm) of creatine at different concentrations could be detected by 3.0T MRI, and the signal intensity was increased with the increase of concentration (r = 0.963, P 0.001). In addition, there were significant differences in CEST effect among different pH values (FV 5.539 P0. 002), and the signal decreased gradually with the decrease of pH value (r 0. 41% P0. 035). Conclusion it is feasible to evaluate creatine metabolism by CEST imaging with 3.0T MRI, and its CEST effect is affected by creatine concentration and pH value of metabolic environment.
【作者單位】： 四川大學(xué)華西第二醫(yī)院放射科婦兒疾病與出生缺陷教育部重點(diǎn)實(shí)驗(yàn)室;四川大學(xué)華西醫(yī)院放射科;貴州遵義醫(yī)學(xué)院附屬醫(yī)院影像科;西門子醫(yī)療東北亞磁共振科研合作部;西門子澳大利亞有限公司醫(yī)療事業(yè)部;
【基金】：國家自然科學(xué)基金(No.81471721) 教育部新世紀(jì)優(yōu)秀人才支持計(jì)劃(No.NCET-13-0386) 四川省應(yīng)用基礎(chǔ)研究項(xiàng)目(No.2014JY0157) 成都市科技惠民項(xiàng)目(No.2014-HM01-00077-SF)資助
【分類號(hào)】：R445.2
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本文編號(hào)：2362694