發(fā)布時間：2018-11-28 11:26

【摘要】：目的探討3.0T MRI化學交換飽和位移成像技術(chemical exchange saturation transfer,CEST)對肌酸代謝成像的可行性及相關影響因素。方法準備不同濃度肌酸及其代謝產物的體外模型和不同pH值的肌酸及其對照組體外模型。采用3.0T MRI對這兩組模型進行CEST成像,通過CEST效應及Z譜進行量化分析。結果 3.0T MRI可檢測到不同濃度肌酸之間信號(±1.8ppm)差異明顯(F=99.08,P0.001),且信號強度隨著濃度增加而增強(r=0.963,P0.001)。另外,不同pH值環(huán)境CEST效應差異明顯(F=5.539,P=0.002),信號隨pH值下降而逐漸減低(r=0.41,P=0.035)。結論 3.0T MRI進行CEST成像評價肌酸代謝是可行的,且其CEST效應受肌酸濃度及代謝環(huán)境pH值等因素影響。
[Abstract]:Objective to investigate the feasibility and related factors of 3.0T MRI chemical-exchange saturated displacement imaging (chemical exchange saturation transfer,CEST) on creatine metabolism imaging. Methods in vitro models of creatine and its metabolites with different concentrations of creatine and creatine with different pH values were prepared. The CEST imaging of the two groups of models was performed with 3.0T MRI, and the CEST effect and Z spectrum were analyzed quantitatively. Results the signal (鹵1.8ppm) of creatine at different concentrations could be detected by 3.0T MRI, and the signal intensity was increased with the increase of concentration (r = 0.963, P 0.001). In addition, there were significant differences in CEST effect among different pH values (FV 5.539 P0. 002), and the signal decreased gradually with the decrease of pH value (r 0. 41% P0. 035). Conclusion it is feasible to evaluate creatine metabolism by CEST imaging with 3.0T MRI, and its CEST effect is affected by creatine concentration and pH value of metabolic environment.
【作者單位】： 四川大學華西第二醫(yī)院放射科婦兒疾病與出生缺陷教育部重點實驗室;四川大學華西醫(yī)院放射科;貴州遵義醫(yī)學院附屬醫(yī)院影像科;西門子醫(yī)療東北亞磁共振科研合作部;西門子澳大利亞有限公司醫(yī)療事業(yè)部;
【基金】：國家自然科學基金(No.81471721) 教育部新世紀優(yōu)秀人才支持計劃(No.NCET-13-0386) 四川省應用基礎研究項目(No.2014JY0157) 成都市科技惠民項目(No.2014-HM01-00077-SF)資助
【分類號】：R445.2
，

本文編號：2362694