【摘要】：目的應(yīng)用磁共振擴(kuò)散成像技術(shù)探討兒童皮質(zhì)脊髓束年齡和性別差異及其變化規(guī)律。方法 90例無(wú)中樞神經(jīng)系統(tǒng)癥狀及體征且顱腦磁共振檢查正常的兒童(年齡5d~18歲)。按年齡分為5組:嬰兒組(組1,≤1歲),幼兒組(組2,1~3歲),學(xué)齡前組(組3,3~6歲),學(xué)齡組(組4,6~12歲),青春發(fā)育期組(組5,12~18歲)。每個(gè)年齡組內(nèi)再按性別分為男、女2組。各組兒童分別行頭部擴(kuò)散張量成像,根據(jù)感興趣法選取皮質(zhì)脊髓束感興趣區(qū)并重建,測(cè)量重建的皮質(zhì)脊髓束的擴(kuò)散張量參數(shù)并進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果各年齡組的表觀擴(kuò)散系數(shù)(ADC)值、分?jǐn)?shù)各向異性(FA)值、纖維示蹤平均長(zhǎng)度、體積以及示蹤的纖維束數(shù)量不完全相同(P0.01);組間的兩兩比較間發(fā)現(xiàn),1組與2組間ADC值、FA值及示蹤纖維平均長(zhǎng)度差異具有統(tǒng)計(jì)學(xué)意義;2組與3組間FA值差異具有統(tǒng)計(jì)學(xué)意義;3組與4組間ADC值、FA值、示蹤纖維平均長(zhǎng)度、纖維束數(shù)目及體積差異均具有統(tǒng)計(jì)學(xué)意義。ADC值與年齡間呈負(fù)相關(guān),余參數(shù)與年齡間呈正相關(guān)。結(jié)論兒童皮質(zhì)脊髓束發(fā)育具有階段性,且具有階段性特征;磁共振擴(kuò)散張量技術(shù)可用于觀測(cè)兒童皮質(zhì)脊髓束,評(píng)價(jià)其發(fā)育狀況。
[Abstract]:Objective to investigate the age and sex differences of corticospinal tract in children by using magnetic resonance diffusion imaging (MRI). Methods 90 children (aged 5d~18) with no symptoms and signs of central nervous system and normal craniocerebral magnetic resonance examination were studied. They were divided into five groups according to their age: infant group (group 1, 鈮，

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