發(fā)布時(shí)間：2018-11-19 16:22

【摘要】：目的采用圖論衍生的成本整合(CI)分析對(duì)復(fù)發(fā)緩解型多發(fā)性硬化(RRMS)患者默認(rèn)網(wǎng)絡(luò)(DMN)亞區(qū)間(內(nèi))相互關(guān)系進(jìn)行研究。方法采集24例處于緩解期的RRMS患者及相同數(shù)量健康對(duì)照組靜息態(tài)功能磁共振(R-f MRI)和高分辨率T1WI數(shù)據(jù)。R-f MRI數(shù)據(jù)處理助手(DPARSFA)基于Matlab2012a平臺(tái)進(jìn)行數(shù)據(jù)預(yù)處理,提取DMN核心和雙側(cè)亞系統(tǒng)區(qū)20個(gè)感興趣區(qū)信號(hào),Pearson相關(guān)計(jì)算功能連接系數(shù)為邊,計(jì)算并比較兩組維持網(wǎng)絡(luò)不碎裂條件下,DMN亞區(qū)間(內(nèi))的CI值的改變,及與臨床參數(shù)如臨床擴(kuò)展殘疾量表(EDSS)、同步聽(tīng)覺(jué)連續(xù)加法測(cè)驗(yàn)評(píng)分(PASAT)、腦實(shí)質(zhì)分?jǐn)?shù)(BPF)、T2WI可見(jiàn)病灶體積和病程的相關(guān)性。結(jié)果最小網(wǎng)絡(luò)密度(Dmin)條件下,RRMS患者DMN功能網(wǎng)絡(luò)左側(cè)顳中葉(MTL)亞系統(tǒng)區(qū)成本整合(0.80 vs.0.30)較對(duì)照組顯著增高(P=0.006),且和BPF之間呈負(fù)相關(guān)(r=-0.414,P=0.045)。結(jié)論處于緩解期的RRMS患者,存在和腦萎縮相關(guān)的DMN亞區(qū)成本整合增高改變。該方法為理解疾病狀態(tài)下的功能整合機(jī)制提供了新的視角。
[Abstract]:Objective to study the relationship between default network (DMN) subinterval (internal) of recurrent multiple sclerosis (RRMS) patients with relapsed multiple sclerosis (RMS) by means of graph derived cost integration (CI) analysis. Methods resting functional magnetic resonance imaging (R-f MRI) and high-resolution T1WI data were collected from 24 patients with RRMS in remission and the same number of healthy controls. R-f MRI data processing assistant (DPARSFA) was used for data preprocessing based on Matlab2012a platform. DMN core and bilateral sub-system signals of 20 regions of interest were extracted, and the functional connection coefficient of Pearson correlation was calculated as edge. The changes of CI value of DMN subinterval (inner) were calculated and compared under the condition of maintaining the network without fragmentation. And its correlation with clinical parameters, such as clinical extended disability scale (EDSS), simultaneous auditory continuous addition test (PASAT), brain parenchyma score (BPF), T2WI), lesion volume and course of disease. Results under the condition of minimal network density (Dmin), the cost integration of (MTL) subsystem in the left temporal middle temporal lobe of DMN patients with RRMS was significantly higher than that in the control group (P0. 006). There was a negative correlation with BPF (r = 0.414, P < 0. 045). Conclusion in patients with RRMS in remission period, the cost integration of DMN subregion associated with brain atrophy is increased. This method provides a new perspective for understanding the mechanism of functional integration in disease state.
【作者單位】： 南昌大學(xué)第一附屬醫(yī)院影像科 江西省醫(yī)學(xué)影像研究所;南昌市第二醫(yī)院腫瘤科;
【基金】：國(guó)家自然科學(xué)基金(編號(hào):81060116,81101041,81260217) 江西省科技支撐計(jì)劃項(xiàng)目(編號(hào):20111BBG70028-1) 江西省青年自然科學(xué)基金(編號(hào):2013BAB215008)
【分類號(hào)】：R744.51;R445.2

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