【摘要】：目的采用高頻超聲生物顯微鏡（HFB,40MHz）觀察二丙酸倍他米松治療病理性瘢痕效果的臨床研究。 方法對(duì)39例接受二丙酸倍他米松局部注射治療的患者（治療組）和20例未接受任何治療的患者（對(duì)照組）以40MHz探頭行高頻超聲檢查，，于第1、31、61、91天測(cè)量瘢痕橫徑、垂直厚度；以DFY型超聲圖像診斷儀測(cè)量其面積、平均灰度值、聲強(qiáng)值；同時(shí)結(jié)合溫哥華瘢痕量表(VSS)對(duì)瘢痕評(píng)分。 結(jié)果治療組：第31、61、91天較治療前橫徑、垂直厚度明顯減�。≒均0.05），面積、平均灰度值、平均聲強(qiáng)值明顯減�。≒均0.05），VSS評(píng)分明顯降低（P均0.01）；第61天較第31天、第91天較第61天以上各參數(shù)均明顯減�。≒0.05），評(píng)分明顯降低（P0.01）。對(duì)照組：各參數(shù)及評(píng)分均降低，但差異均無統(tǒng)計(jì)學(xué)意義（P均0.05）。 結(jié)論高頻超聲生物顯微鏡能無創(chuàng)、定量觀察二丙酸倍他米松局部治療后病理性瘢痕改變，對(duì)其治療情況的評(píng)價(jià)有一定的臨床價(jià)值。
[Abstract]:Objective to observe the therapeutic effect of betamethasone dipropionate on pathological scar by high frequency ultrasound biomicroscopy (HFB,40MHz). Methods 39 patients (treatment group) and 20 patients (control group) who received local injection of betamethasone dipropionate were examined by high frequency ultrasound with 40MHz probe. The area, average gray value and sound intensity were measured with DFY ultrasonic imaging diagnostic instrument, and the scar score was evaluated with Vancouver scar scale (VSS). Results in the treatment group, the transverse diameter, vertical thickness, area, average gray value and average sound intensity were significantly decreased on day 31 (61 / 91) compared with those before treatment (P < 0. 05). On the 61st day, on the 31st day, on the 91st day, the parameters decreased obviously (P0.05), and the score decreased significantly (P0.01). In control group, all parameters and scores were decreased, but the difference was not statistically significant (P 0.05). Conclusion High frequency ultrasound biomicroscope can be used to quantitatively observe pathological scar changes after local treatment of betamethasone dipropionate.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R445.1;R622

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