發(fā)布時間：2018-10-30 09:20

【摘要】：目的應用靜息態(tài)功能磁共振(RS-f MRI)局部一致性(Re Ho)技術(shù),探討僅有脊髓受累型多發(fā)性硬化患者(MS-SSCI)血氧水平依賴信號的Re Ho。方法對23例MS-SSCI患者(MS-SSCI組)及23名年齡、性別相匹配的健康志愿者(對照組)進行RS-f MRI掃描,比較兩組間Re Ho改變的腦區(qū),進一步分析MS-SSCI患者Re Ho值與臨床擴展殘疾狀態(tài)量表(EDSS)評分及病程間的相關(guān)性。結(jié)果與對照組相比,MS-SSCI患者左側(cè)小腦腳Ⅱ、雙側(cè)顳中回、左側(cè)紡錘體、左側(cè)中央前回、右側(cè)輔助運動區(qū)的Re Ho明顯降低;左側(cè)小腦Ⅸ區(qū)、雙側(cè)尾狀核、左側(cè)后扣帶回的Re Ho明顯升高(雙樣本t檢驗,經(jīng)Alpha Sim校正,P0.01,體素大小40)。相關(guān)性分析結(jié)果顯示,MS-SSCI患者左側(cè)后扣帶回Re Ho值和EDSS呈正相關(guān)(r=0.586,P=0.003)。結(jié)論 MS-SSCI患者靜息狀態(tài)下存在局部腦功能異常,且功能異常與臨床殘疾狀況密切相關(guān),RS-f MRI在探測MS-SSCI腦內(nèi)潛在性病變方面具有重要價值。
[Abstract]:Objective to investigate the application of resting functional magnetic resonance (RS-f MRI) locally consistent (Re Ho) technique in the study of Re Ho. with only oxygen-dependent signal in patients with multiple sclerosis (MS-SSCI) with spinal cord involvement. Methods RS-f MRI scans were performed in 23 MS-SSCI patients (MS-SSCI group) and 23 age-matched healthy volunteers (control group). The brain regions of Re Ho were compared between the two groups. To further analyze the correlation between Re Ho value of MS-SSCI patients and (EDSS) score of clinical extended disability status scale and course of disease. Results compared with the control group, the Re Ho of left cerebellum 鈪，

本文編號：2299595