【摘要】：目的探討聲輻射力脈沖成像技術(shù)(ARFI)及二維剪切波彈性成像技術(shù)(2D-SWE)在診斷肝臟纖維化等級(LF)方面的差異。方法新西蘭大白兔60只,隨機分為對照組(10只,無處理)和LF組(50只,注射四氯化碳以建立不同程度的LF模型)。利用ARFI及2D-SWE對所有動物進行肝臟硬度(LS)的測定,并取相同部位肝臟組織進行病理學分析,根據(jù)Spearman等級相關(guān)分析LF及LS之間相關(guān)性,通過構(gòu)建受試者工作特性曲線比較兩種技術(shù)在診斷效能方面的差異。結(jié)果共成功取得37只動物的實驗數(shù)據(jù),其中F0級14處、F1級11處、F2級15處、F3級12處、F4級22處。所有動物均成功進行LS的測定,LF與ARFI測定結(jié)果之間呈線性相關(guān)(r=0.802,P0.01),與2D-SWE測定結(jié)果呈線性相關(guān)(r=0.892,P0.01)。成功構(gòu)建受試者工作特性曲線,ARFI診斷LFF0、F1、F2、F3的曲線下面積分別為0.809、0.916、0.938、0.934;2D-SWE診斷LFF0、F1、F2、F3的曲線下面積分別為0.917、0.935、0.976、0.974。結(jié)論 ARFI及2D-SWE技術(shù)均能較為準確地反應LF的等級,且2D-SWE技術(shù)的診斷效能優(yōu)于ARFI技術(shù)。
[Abstract]:Objective to investigate the difference between acoustic radiation pulse imaging (ARFI) and two-dimensional shear wave elastography (2D-SWE) in the diagnosis of hepatic fibrosis grade (LF). Methods 60 New Zealand white rabbits were randomly divided into control group (10 rabbits, without treatment) and LF group (50 rabbits), which were injected with carbon tetrachloride to establish LF model. ARFI and 2D-SWE were used to determine the liver hardness (LS) of all animals, and the liver tissues of the same parts were taken for pathological analysis. The correlation between LF and LS was analyzed according to the Spearman grade correlation. The difference of diagnostic efficiency between the two techniques was compared by constructing the operating characteristic curve of the subjects. Results A total of 37 experimental data of 37 animals were successfully obtained, of which 14 were F0, 14, F _ 1, 11, F _ 2, 15, F _ 3, 12, and 12, F _ 4, 22, respectively. There was a linear correlation between LF and ARFI in all animals (r = 0.802, P 0.01) and a linear correlation with the results of 2D-SWE (r = 0.892g, P 0.01). The area under the curve for the diagnosis of LFF0,F1,F2,F3 by ARFI was 0.809 ~ 0.938 ~ 0.934 ~ 2D-SWE, respectively. The area under the curve was 0.917 ~ 0.935 ~ 0.97 ~ (6) ~ 0.974, respectively. Conclusion both ARFI and 2D-SWE can accurately reflect the grade of LF, and the diagnostic efficacy of 2D-SWE is better than that of ARFI.
【作者單位】： 中國人民解放軍總醫(yī)院超聲診斷科;
【分類號】：R445.1

【參考文獻】

相關(guān)期刊論文 前2條

1 Akihiko Osaki;Tomoyuki Kubota;Takeshi Suda;Masato Igarashi;Keisuke Nagasaki;Atsunori Tsuchiya;Masahiko Yano;Yasushi Tamura;Masaaki Takamura;Hirokazu Kawai;Satoshi Yamagiwa;Toru Kikuchi;Minoru Nomoto;Yutaka Aoyagi;;Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis[J];World Journal of Gastroenterology;2010年23期

2 唐文博;焦子育;穆晨;羅渝昆;劉迎娣;唐杰;;內(nèi)鏡下食管胃底靜脈曲張治療對肝硬化患者肝臟及脾臟彈性指數(shù)的影響[J];中國醫(yī)學影像學雜志;2013年05期

【共引文獻】

相關(guān)期刊論文 前10條

1 于樂成;何長倫;汪茂榮;;乙型肝炎肝硬化抗病毒治療的研究進展[J];實用肝臟病雜志;2010年04期

2 黃勇躍;金軍;湯小俐;王小宜;;擴散加權(quán)成像和瞬時彈性成像在肝纖維化診斷價值中的對比研究[J];磁共振成像;2013年04期

3 李寶亮;穆毅;蔣力;張珂;賈哲;黃容海;魯巖;赫嶸;丁振昊;李勤濤;郭立民;;Child-Pugh分級聯(lián)合ICG與肝瞬時彈性值評估肝部分切除術(shù)肝細胞癌患者肝儲備功能[J];中國肝臟病雜志(電子版);2013年03期

4 陸倫根;;肝纖維化非創(chuàng)傷性診斷評估及其臨床應用[J];國際消化病雜志;2013年05期

5 田麗艷;陸倫根;;肝纖維化影像學診斷研究進展[J];國際消化病雜志;2013年05期

6 Roberto Catanzaro;Michele Milazzo;Silvia Arona;Chiara Sapienza;Dario Vasta;Domenico Arcoria;Francesco Marotta;;Diagnostic accuracy of enhanced liver fibrosis test to assess liver fibrosis in patients with chronic hepatitis C[J];Hepatobiliary & Pancreatic Diseases International;2013年05期

7 武桂萍;顏學兵;王興田;郝俊貴;沈培璞;柳紅;;聲觸診組織量化技術(shù)無創(chuàng)評價慢性肝病肝纖維化程度的初步研究[J];中國肝臟病雜志(電子版);2013年04期

8 Ryota Masuzaki;Masao Omata;;Prevention of Hepatocellular Carcinoma[J];Infection International(Electronic Edition);2012年01期

9 夏長虹;王文歡;王偉芳;郭漢斌;李浩然;李亞松;曹建彪;;Fibrotouch與Fibroscan檢測肝臟硬度的臨床效能比較[J];北京醫(yī)學;2014年03期

10 劉京;劉映霞;董常峰;姚思敏;李莎茜;袁靜;陳川鐵;趙美芬;林益敏;彭忠田;;ARFI、Forns指數(shù)、FIB-4和APRI無創(chuàng)診斷慢性乙型病毒性肝炎肝纖維化的研究[J];中國肝臟病雜志(電子版);2014年01期

相關(guān)會議論文 前1條

1 陳永鵬;梁攜兒;張琪;戴琳;彭R，

本文編號：2234948