【摘要】：目的探討聲輻射力脈沖成像技術(shù)(ARFI)及二維剪切波彈性成像技術(shù)(2D-SWE)在診斷肝臟纖維化等級(jí)(LF)方面的差異。方法新西蘭大白兔60只,隨機(jī)分為對(duì)照組(10只,無處理)和LF組(50只,注射四氯化碳以建立不同程度的LF模型)。利用ARFI及2D-SWE對(duì)所有動(dòng)物進(jìn)行肝臟硬度(LS)的測(cè)定,并取相同部位肝臟組織進(jìn)行病理學(xué)分析,根據(jù)Spearman等級(jí)相關(guān)分析LF及LS之間相關(guān)性,通過構(gòu)建受試者工作特性曲線比較兩種技術(shù)在診斷效能方面的差異。結(jié)果共成功取得37只動(dòng)物的實(shí)驗(yàn)數(shù)據(jù),其中F0級(jí)14處、F1級(jí)11處、F2級(jí)15處、F3級(jí)12處、F4級(jí)22處。所有動(dòng)物均成功進(jìn)行LS的測(cè)定,LF與ARFI測(cè)定結(jié)果之間呈線性相關(guān)(r=0.802,P0.01),與2D-SWE測(cè)定結(jié)果呈線性相關(guān)(r=0.892,P0.01)。成功構(gòu)建受試者工作特性曲線,ARFI診斷LFF0、F1、F2、F3的曲線下面積分別為0.809、0.916、0.938、0.934;2D-SWE診斷LFF0、F1、F2、F3的曲線下面積分別為0.917、0.935、0.976、0.974。結(jié)論 ARFI及2D-SWE技術(shù)均能較為準(zhǔn)確地反應(yīng)LF的等級(jí),且2D-SWE技術(shù)的診斷效能優(yōu)于ARFI技術(shù)。
[Abstract]:Objective to investigate the difference between acoustic radiation pulse imaging (ARFI) and two-dimensional shear wave elastography (2D-SWE) in the diagnosis of hepatic fibrosis grade (LF). Methods 60 New Zealand white rabbits were randomly divided into control group (10 rabbits, without treatment) and LF group (50 rabbits), which were injected with carbon tetrachloride to establish LF model. ARFI and 2D-SWE were used to determine the liver hardness (LS) of all animals, and the liver tissues of the same parts were taken for pathological analysis. The correlation between LF and LS was analyzed according to the Spearman grade correlation. The difference of diagnostic efficiency between the two techniques was compared by constructing the operating characteristic curve of the subjects. Results A total of 37 experimental data of 37 animals were successfully obtained, of which 14 were F0, 14, F _ 1, 11, F _ 2, 15, F _ 3, 12, and 12, F _ 4, 22, respectively. There was a linear correlation between LF and ARFI in all animals (r = 0.802, P 0.01) and a linear correlation with the results of 2D-SWE (r = 0.892g, P 0.01). The area under the curve for the diagnosis of LFF0,F1,F2,F3 by ARFI was 0.809 ~ 0.938 ~ 0.934 ~ 2D-SWE, respectively. The area under the curve was 0.917 ~ 0.935 ~ 0.97 ~ (6) ~ 0.974, respectively. Conclusion both ARFI and 2D-SWE can accurately reflect the grade of LF, and the diagnostic efficacy of 2D-SWE is better than that of ARFI.
【作者單位】： 中國人民解放軍總醫(yī)院超聲診斷科;
【分類號(hào)】：R445.1

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