【摘要】：目的探討定量反饋控制實(shí)時(shí)組織彈性成像(RTE)檢查過(guò)程中探頭施加的壓力區(qū)間與壓放頻率對(duì)應(yīng)變比值(SR)測(cè)量重復(fù)性和準(zhǔn)確性的影響。方法在日立HI VISION preirus型超聲診斷儀,EUP-L74M淺表超聲探頭兩側(cè)分別加裝一個(gè)FS01型壓力傳感器,構(gòu)成壓力反饋式超聲彈性成像探頭(以下簡(jiǎn)稱壓力探頭),通過(guò)圖像采集卡和數(shù)據(jù)采集卡將彈性圖像和探頭施予組織的“輕壓-解壓”的壓力區(qū)間和壓放頻率實(shí)時(shí)傳輸?shù)焦P記本電腦操作面板上便于及時(shí)調(diào)控和觀察,通過(guò)該系統(tǒng)可以實(shí)時(shí)調(diào)整探頭壓力區(qū)間及壓放頻率以獲得滿意的彈性成像圖。實(shí)驗(yàn)分別對(duì)壓力探頭做重復(fù)性及準(zhǔn)確性檢驗(yàn),方法如下:(1)重復(fù)性實(shí)驗(yàn):15位不同熟練度的操作者分別對(duì)楊氏模量為80 kPa、直徑為10.4 mm、中心深度為3 cm的超聲圓柱形仿體進(jìn)行3組不同條件下的RTE檢查:組1為參考?jí)悍磐扑]指標(biāo)2-3的常規(guī)方法;組2在0~80 g的壓力區(qū)間、1.5次/s的壓放頻率引導(dǎo)下進(jìn)行彈性成像檢查;組3在40~120 g的壓力區(qū)間、1.5次/s的壓放頻率的引導(dǎo)下進(jìn)行檢查,每組條件下均對(duì)滿意的彈性成像圖進(jìn)行SR值測(cè)量,每位醫(yī)師每組條件下均測(cè)量15次SR值,計(jì)算每位醫(yī)師各組SR測(cè)量值的CV值,并分析組與組之間CV值有無(wú)明顯差異。(2)準(zhǔn)確性實(shí)驗(yàn):分別在使用儀器自帶的壓放推薦指標(biāo)2-3(對(duì)照組)和在0~100g壓力區(qū)間、1.5次/s壓放頻率的引導(dǎo)條件下(實(shí)驗(yàn)組)測(cè)量彈性模量為(8,14,45和80kPa),直徑10.4 mm,中心深度3cm的4處圓柱形超聲仿體的應(yīng)變比值(SR),兩組條件下每個(gè)硬度仿體各測(cè)量45次,并將每組條件下測(cè)量數(shù)據(jù)分為3組,計(jì)算并比較組Ⅰ(80 kPa vs 45,14,8 kPa),組Ⅱ(80,45 kPa vs 14,8 kPa)和組Ⅲ(80,45,14kPa vs 8 kPa)的兩組實(shí)驗(yàn)條件下的ROC曲線下面積(AUC),以及兩組條件下測(cè)得4種彈性模量仿體的SR值有無(wú)差異。結(jié)果(1)重復(fù)性實(shí)驗(yàn):3組條件下15位操作醫(yī)師的CV值比較,差異有統(tǒng)計(jì)學(xué)意義(F=15.853,P0.001),組2與組3的CV值均低于組1的CV值,差異均有統(tǒng)計(jì)學(xué)意義(q=4.732,P0.001;q=5.038,P0.001),組2與組3的CV值比較,無(wú)統(tǒng)計(jì)學(xué)差異(q=0.625,P=0.685)。(2)準(zhǔn)確性實(shí)驗(yàn):兩組條件下組Ⅰ和組Ⅱ的ROC曲線的AUC之間差異無(wú)統(tǒng)計(jì)學(xué)意義(P=1.000),實(shí)驗(yàn)組的組Ⅲ的AUC大于對(duì)照組(P=0.0379);對(duì)照組中8kPa和14kPa的SR值之間差異無(wú)統(tǒng)計(jì)學(xué)意義(P=0.258),對(duì)照組中8,45和80kPa之間,14,45和80kPa之間以及實(shí)驗(yàn)組中四種彈性模量的仿體SR值之間差異均有統(tǒng)計(jì)學(xué)意義(P0.001)。結(jié)論通過(guò)對(duì)RTE檢查中的壓力區(qū)間與壓放頻率進(jìn)行定量控制來(lái)指導(dǎo)醫(yī)師操作較使用壓放推薦指標(biāo)2-3可以提高其SR值測(cè)量重復(fù)性和準(zhǔn)確性。
[Abstract]:Objective to investigate the effects of the pressure range and pressure-discharge frequency of the probe on the repeatability and accuracy of the strain ratio (SR) measurement in quantitative feedback controlled real-time tissue elastic imaging (RTE). Methods one FS01 pressure sensor was installed on both sides of Hitachi HI VISION preirus ultrasonic diagnostic instrument. The pressure feedback ultrasonic elastic imaging probe (hereinafter referred to as the pressure probe) is constructed. The elastic image and probe are applied to the "light pressure-decompression" pressure range and pressure-release frequency of the tissue through the image acquisition card and the data acquisition card in real time. Transmitted to the laptop operating panel for timely control and observation, Through this system, the probe pressure range and pressure-frequency can be adjusted in real time to obtain a satisfactory elastic imaging diagram. The repeatability and accuracy of the pressure probe were tested. The methods were as follows: (1) repetitive experiment: 15 operators with different proficiency performed three groups of RTE tests under different conditions for ultrasonic cylindrical phantom with Young's modulus of 80 kPa, diameter of 10.4 mm, center depth of 3 cm: group 1 as reference. The conventional method of pressure-setting recommendation index 2-3; Group 2 was examined by elastic imaging under the guidance of the pressure frequency of 1.5 times / s in the pressure range of 0 ~ 80 g, and group 3 under the guidance of 1.5 times / s in the pressure range of 40 ~ 120 g / s. The SR values of each group were measured in each group, the SR values of each group were measured 15 times, and the CV values of SR values were calculated for each group of physicians. (2) accuracy experiment: under the guidance of the recommended pressure-drop index 2-3 (control group) and the 0 ~ 100g pressure range 1.5 times / s pressure-release frequency (experimental group). The elastic modulus was (8 / 14 / 45 and 80kPa) and the strain ratio of cylindrical ultrasonic imitating body at 4 points of 3cm (diameter 10.4 mm, center depth) was measured 45 times for each hardness imitating body under the condition of (SR), group. The data were divided into three groups under each condition. The area (AUC), under the ROC curve of group 鈪，

本文編號(hào)：2233681