發(fā)布時(shí)間：2018-06-21 06:43

  本文選題：出血性轉(zhuǎn)化 + 彌散加權(quán)成像　； 參考：《中國(guó)醫(yī)學(xué)計(jì)算機(jī)成像雜志》2016年04期

【摘要】：目的:探討3.0T磁共振彌散加權(quán)成像(DWI)中表觀(guān)彌散系數(shù)(ADC)值及指數(shù)表觀(guān)彌散系數(shù)(e ADC)值對(duì)兔急性腦缺血性腦卒中出血性轉(zhuǎn)化(HT)的預(yù)測(cè)價(jià)值。方法:37只新西蘭大白兔頸內(nèi)動(dòng)脈注射自體血栓制備急性腦缺血性腦卒中模型,模型制備3.5h時(shí)行DWI檢查,模型制備成功者,術(shù)后4h行尿激酶靜脈溶栓。模型成功72h后處死動(dòng)物,行HE染色。應(yīng)用SPSS16.0統(tǒng)計(jì)學(xué)軟件,采用獨(dú)立樣本t檢驗(yàn)比較無(wú)HT組與HT組之間ADC值、e ADC值的差異有無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)果:27只新西蘭大白兔急性缺血性腦卒中模型制作成功,其中6例發(fā)展為HT,HI型5例,PH型1例。無(wú)HT組3.5h梗死區(qū)ADC值為(0.752±0.114)×10-3mm~2/s,HT組ADC值為(0.482±0.068)×10~(-3)mm~2/s,兩組ADC值的差異有統(tǒng)計(jì)學(xué)意義(P=0.000)。無(wú)HT組3.5h梗死區(qū)e ADC值為0.479±0.053,HT組e ADC值為0.618±0.074,兩組e ADC值的差異有統(tǒng)計(jì)學(xué)意義(P=0.000)。結(jié)論:缺血性腦卒中急性期ADC值、e ADC值的改變與HT的發(fā)生存在一定相關(guān)性,ADC值越低、eADC值越高則HT發(fā)生的可能性就越大,這對(duì)臨床溶栓治療的預(yù)后判斷有一定的參考意義。
[Abstract]:Objective: to study the predictive value of apparent diffusion coefficient (ADCC) and exponential apparent diffusion coefficient (e ADCV) in DWI of 3.0T magnetic resonance diffusion weighted imaging (DWI) for hemorrhagic transformation of acute cerebral ischemic stroke in rabbits. Methods the acute cerebral ischemic stroke model was established by injecting autologous thrombosis into the carotid artery of 37 New Zealand white rabbits. DWI was performed at 3.5 hours after the preparation of the model, and urokinase thrombolysis was performed 4 hours after the operation. After 72 hours of success, the animals were killed and stained with HE. Using SPSS 16.0 statistical software, the difference of ADC value between HT group and HT group was compared by independent sample t test. Results the acute ischemic cerebral apoplexy model of 27 New Zealand white rabbits was established successfully, of which 6 cases developed into 5 cases of HT HI type and 1 case of PH type. The ADC value of infarct area in the no HT group at 3.5 h was 0.752 鹵0.114) 脳 10 ~ (-3) mm ~ (-2) / s. The ADC value of the two groups was 0.482 鹵0.068) 脳 10 ~ (-3) mm ~ (-3) / s. The difference of ADC value between the two groups was statistically significant (P < 0.05). The eADC value in the infarct area of the no HT group was 0.479 鹵0.053% (0.618 鹵0.074), and the difference between the two groups was statistically significant (P < 0.05). Conclusion: there is a certain correlation between the change of ADC value and the occurrence of HT in the acute phase of ischemic stroke. The lower the ADC value is, the higher the ADC value is, the more likely it will be, which is useful for the prognosis of thrombolytic therapy.
【作者單位】： 江蘇省徐州市中心醫(yī)院CT室;江蘇省徐州醫(yī)學(xué)院附屬醫(yī)院影像科;
【基金】：徐州市科技計(jì)劃項(xiàng)目KC14SH019~~
【分類(lèi)號(hào)】：R445.2;R743.3
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本文編號(hào)：2047632