本文選題：實時功能磁共振 + 神經(jīng)反饋��； 參考：《浙江大學》2017年碩士論文

【摘要】：隨著磁共振影像技術(shù)廣泛地應用于神經(jīng)科學領(lǐng)域研究,關(guān)于大腦的功能分析不斷涌現(xiàn),幫助人們揭示了大腦的奧秘。其中,傳統(tǒng)的功能磁共振研究雖然實驗設計多種多樣,但因其實驗業(yè)務流程比較固定,在一定程度上限制了實驗變量的設定。本文在實現(xiàn)實時功能磁共振閉環(huán)回路系統(tǒng)的基礎(chǔ)上,以感興趣區(qū)血氧水平依賴(blood oxygen level dependent,BOLD)信號強度作為神經(jīng)反饋實驗設計變量,探索了受試者的自我調(diào)控能力對其大腦任務響應程度的影響。同時,結(jié)合了多層同時成像技術(shù)和局部掃描技術(shù)采集方法提高了實時功能磁共振的時間分辨率和空間分辨率,進而縮短了神經(jīng)反饋的周期,增加了神經(jīng)反饋的精細性。實驗結(jié)果表明,經(jīng)過神經(jīng)反饋訓練的所有受試者相較于對照組都能夠明顯地抑制大腦額中回感興趣區(qū)對負面情緒圖片刺激的響應水平。并且,在綜合了普通EPI、multiband-EPI和ZOOMit-EPI序列采集得到的任務實驗激活區(qū)BOLD信號強度響應的情況下,發(fā)現(xiàn)ZOOMit-EPI采集方法能夠在激活區(qū)提供更高的平靜和刺激狀態(tài)信號強度對比度。改善實驗業(yè)務流程不但可以拓展研究實驗中變量的設計,而且可以幫助提高臨床病人的功能任務實驗掃描的效率。為此,本文基于實時功能磁共振提出了一種具有實時更新和監(jiān)控功能的實驗任務刺激系統(tǒng)。該系統(tǒng)通過檢測受試者的任務實驗響應情況幫助主試者判斷是否提前無縫切換任務實驗至新階段。該系統(tǒng)不僅可以監(jiān)測數(shù)據(jù)的質(zhì)量,還可以縮短任務實驗掃描總時長,具有十分重要的實際應用價值。
[Abstract]:With the wide application of magnetic resonance imaging (MRI) in the field of neuroscience, functional analysis of the brain is emerging, which helps to reveal the mystery of the brain. The traditional functional magnetic resonance (fMRI) study has a variety of experimental designs, but its experimental business process is relatively fixed, which limits the setting of experimental variables to a certain extent. In this paper, based on the realization of real-time functional magnetic resonance closed-loop system, the signal intensity of blood oxygen level dependent Bod in the region of interest is used as the neural feedback experimental design variable. The effects of subjects' self-regulation ability on their brain task response were investigated. At the same time, the time resolution and spatial resolution of real-time fMRI are improved by combining multi-layer simultaneous imaging technique and local scanning technique, and the period of neural feedback is shortened and the fineness of neural feedback is increased. The results showed that all subjects trained with neural feedback could significantly inhibit the response level of the region of interest in frontal gyrus to the stimulation of negative emotional images compared with the control group. Furthermore, under the condition of synthesizing the signal intensity response of the activation region of the task experiment obtained from the common EPII-multiband-EPI and ZOOMit-EPI sequences, it is found that the ZOOMit-EPI acquisition method can provide a higher calm and contrast of the signal intensity of the stimulus state in the activation region. Improving the experimental business process can not only expand the design of the variables in the research experiment, but also help to improve the efficiency of the functional task experimental scanning of the clinical patients. Therefore, based on real-time functional magnetic resonance, an experimental task stimulation system with real-time updating and monitoring function is proposed. The system can help the subjects to decide whether to switch tasks seamlessly to the new stage by detecting the subjects' response to the task experiment. The system can not only monitor the quality of data, but also shorten the total scanning time of task experiment. It has very important practical application value.
【學位授予單位】：浙江大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：TP274;R445.2

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