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新兵適應(yīng)障礙的亞頻段低頻振幅功能MRI研究

發(fā)布時(shí)間:2018-06-05 23:16

  本文選題:適應(yīng)障礙 + 低頻振幅 ; 參考:《放射學(xué)實(shí)踐》2017年12期


【摘要】:目的:應(yīng)用亞頻段低頻振幅(ALFF)分析方法,研究適應(yīng)障礙新兵腦靜息狀態(tài)下自發(fā)性神經(jīng)活動(dòng)改變的特點(diǎn)。方法:17例適應(yīng)障礙新兵及20例健康軍人(對照組)行靜息態(tài)下腦功能MRI掃描,成像數(shù)據(jù)經(jīng)后處理,獲得各頻段的ALFF圖,采用雙樣本t檢驗(yàn)比較兩組間各頻段ALFF值的差異,并分析ALFF值改變與患者臨床量表評分之間的相關(guān)性。結(jié)果:與正常對照組比較,患者組在Slow-5亞頻段ALFF值減低的腦區(qū)包括右側(cè)小腦腳、左側(cè)眶部額下回、左內(nèi)側(cè)前額葉、右側(cè)額中回及雙側(cè)額上回(P0.01,AlphaSim校正),在Slow-4亞頻段ALFF值減低的腦區(qū)有左內(nèi)側(cè)前額葉和左側(cè)眶部額下回(P0.01,AlphaSim校正);颊呓M中各ALFF值異常腦區(qū)的ALFF值與臨床量表評分間的相關(guān)性均無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:適應(yīng)障礙新兵有多個(gè)腦區(qū)存在自發(fā)性神經(jīng)活動(dòng)異常,這些腦區(qū)與認(rèn)知、情緒調(diào)節(jié)及執(zhí)行功能有關(guān),且不同亞頻段異常活動(dòng)腦區(qū)的空間分布不同。
[Abstract]:Objective: to study the characteristics of spontaneous nerve activity in recruits with adaptation disorder under resting state by using subfrequency low frequency amplitude analysis. Methods MRI scans of brain function were performed in 17 recruits with adaptation disorder and 20 healthy soldiers (control group). After post-processing of imaging data, the ALFF images of each frequency band were obtained. The difference of ALFF values between the two groups was compared by double sample t-test. The correlation between the change of ALFF and the clinical scale score was analyzed. Results: compared with the normal control group, the patients with decreased Slow-5 subband ALFF included the right cerebellar foot, the left orbital inferior frontal gyrus, the left medial prefrontal lobe, and the left medial prefrontal lobe. In the right middle frontal gyrus and bilateral superior frontal gyrus, P0.01T AlphaSim correction was found in the left medial prefrontal lobe and left orbital inferior frontal gyrus. There was no significant correlation between ALFF value and clinical scale score in patients with abnormal ALFF value (P 0.05). Conclusion: there are many brain regions with abnormal neural activity in recruits with adaptation disorder. These areas are related to cognition, emotion regulation and executive function, and the spatial distribution of abnormal brain regions in different subfrequency regions is different.
【作者單位】: 中國人民解放軍福州總醫(yī)院影像科;
【基金】:全軍醫(yī)藥衛(wèi)生科研基金資助項(xiàng)目(10Z030)
【分類號(hào)】:R445.2;R82

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