本文選題：青年女性 + 乳腺癌��； 參考：《臨床放射學(xué)雜志》2017年11期

【摘要】：目的回顧性分析青年女性乳腺浸潤性導(dǎo)管癌的動(dòng)態(tài)增強(qiáng)MRI特征,探討早期最大強(qiáng)化率(EPER)及時(shí)間信號(hào)強(qiáng)度曲線(TIC)與Ki-67之間的相關(guān)性。方法搜集術(shù)前均行MRI動(dòng)態(tài)增強(qiáng)掃描并經(jīng)病理證實(shí)的32例青年女性乳腺浸潤性導(dǎo)管癌患者資料,記錄腫瘤的形態(tài)學(xué)及血流動(dòng)力學(xué)特點(diǎn),記錄Ki-67的表達(dá)情況。采用Spearman相關(guān)檢驗(yàn)對(duì)EPER及TIC與Ki-67進(jìn)行相關(guān)性分析。結(jié)果 32例乳腺癌患者的病灶均位于單側(cè)乳腺,非腫塊型6例,腫塊型26例。腫塊型MRI表現(xiàn):不規(guī)則形17例,卵圓形6例,圓形3例;邊緣有毛刺或邊緣不規(guī)則23例,邊緣清晰3例;不均勻強(qiáng)化25例,均勻強(qiáng)化1例;非腫塊型的MRI表現(xiàn):彌漫分布5例,區(qū)域分布1例;不均勻強(qiáng)化占5例,均勻強(qiáng)化占1例。平掃時(shí)T_1低或等信號(hào)27例,T_1稍高或高信號(hào)5例;T_2低或等信號(hào)9例,T_2稍高或高信號(hào)23例;動(dòng)態(tài)增強(qiáng)后的TIC類型:平臺(tái)型4例,流出型28例。Ki-67表達(dá)水平為5%~80%,平均(44.38±22.50)%。EPER及TIC與生物學(xué)因子Ki-67之間的相關(guān)系數(shù)分別為-0.103、0.031(P0.05)。結(jié)論青年女性浸潤性導(dǎo)管癌多表現(xiàn)為形態(tài)不規(guī)則或彌漫分布,邊緣不清晰,T_1低或等信號(hào),T_2稍高信號(hào),增強(qiáng)后呈不均勻強(qiáng)化,TIC曲線呈流出型的MRI特征。本研究顯示,EPER及TIC與生物學(xué)因子Ki-67之間無明確相關(guān)性。
[Abstract]:Objective to analyze the characteristics of dynamic enhanced MRI in young women with invasive ductal carcinoma of breast, and to explore the correlation between early maximum enhancement rate (EPERA) and time signal intensity curve (TICs) and Ki-67. Methods the data of 32 young female breast invasive ductal carcinoma patients who underwent dynamic enhanced MRI scanning before operation and confirmed by pathology were collected. The morphological and hemodynamic characteristics of the tumor and the expression of Ki-67 were recorded. Spearman correlation test was used to analyze the correlation between EPER, TIC and Ki-67. Results the lesions of 32 cases of breast cancer were located in unilateral breast, 6 cases were non-mass type and 26 cases were mass type. MRI findings of mass type were irregular in 17 cases, oval in 6 cases, round in 3 cases, brim or irregular margin in 23 cases, edge clear in 3 cases, uneven enhancement in 25 cases, homogeneous enhancement in 1 case, and diffuse distribution in 5 cases. Regional distribution was found in 1 case, heterogeneous enhancement in 5 cases and homogeneous enhancement in 1 case. 27 cases of low or iso-signal T _ 1 on plain scan 27 cases of T _ 1 slightly high or high signal 5 cases of T _ 2 low or iso-signal 9 cases of T _ 2 slightly high or high signal 23 cases; dynamic enhancement of TIC type: platform type 4 cases, The expression level of Ki-67 was 54.38 鹵22.50)%.EPER, and the correlation coefficient between TIC and Ki-67 was -0.103 and 0.031, respectively. Conclusion the infiltrating ductal carcinoma in young women is characterized by irregular or diffuse distribution, low or equal signal intensity of T _ (2) on the edge of T _ (1) and slightly high signal intensity of T _ (2), and an inhomogeneous enhanced TIC curve with efflux type of MRI after enhancement. This study showed that there was no clear correlation between Eper and TIC and biological factor Ki-67.
【作者單位】： 第二軍醫(yī)大學(xué)附屬長海醫(yī)院放射介入科;第二軍醫(yī)大學(xué)附屬長海醫(yī)院放射科;
【基金】：國家臨床重點(diǎn)專科軍隊(duì)建設(shè)項(xiàng)目資助
【分類號(hào)】：R445.2;R737.9
，

本文編號(hào)：1958634