本文選題：磁共振波譜 + γ-氨基丁酸�。� 參考：《中國醫(yī)學影像技術》2015年12期

【摘要】：目的探討磁共振波譜MEGA-PRESS序列定量檢測紋狀體γ-氨基丁酸(GABA)濃度的可行性及年齡、性別、腦內(nèi)區(qū)域差異與紋狀體GABA濃度的關系。方法招募117名健康的志愿者,對其行三維MP-RAGE序列掃描,并進行冠狀位、矢狀位、軸位圖像重建。ROI定位于雙側(cè)紋狀體,行MEGA-PRESS序列波譜掃描。將掃描數(shù)據(jù)導入LCModel軟件行自動分析,獲取3.0ppm處的GABA含量。結(jié)果最終符合LCModel數(shù)據(jù)標準者共103名。志愿者總體左、右側(cè)GABA濃度均隨年齡增長而減低(F=17.429、10.415),男性志愿者左、右側(cè)(F=9.459、6.666)和女性志愿者左、右側(cè)(F=8.479、3.457)GABA濃度分別隨年齡增長而減低,差異均有統(tǒng)計學意義(P均0.01)。男、女性志愿者左側(cè)與右側(cè)GABA濃度(t=0.471、0.891)及志愿者總體左側(cè)與右側(cè)GABA濃度(t=0.483),差異均無統(tǒng)計學意義(P均0.05)。結(jié)論正常人紋狀體GABA濃度隨年齡增長而減少,不同性別GABA含量相等,GABA呈左右對稱性分布。
[Abstract]:Objective to investigate the feasibility and the relationship between age, sex, brain region difference and striatal GABA concentration in the quantitative detection of striatum 緯 -aminobutyric acid (GABA) concentration by magnetic resonance spectroscopy (MEGA-PRESS) sequence. Methods 117 healthy volunteers were recruited and scanned with 3D MP-RAGE sequence. Coronal, sagittal and axial images were reconstructed in bilateral striatum and scanned by MEGA-PRESS sequence. The scanning data were imported into the LCModel software line for automatic analysis, and the GABA content at 3.0ppm was obtained. Results there were 103 patients who met the LCModel data standard. The total concentration of GABA in the left and right sides of the volunteers decreased with age, while in male volunteers the concentration of GABA decreased with age (P < 0.01), and the concentration of GABA in female volunteers decreased with age (P < 0.01), and that of female volunteers was lower than that of female volunteers (P < 0.01). The concentration of GABA in the left and right sides of male and female volunteers was 0.471U 0.891) and the total concentration of GABA in the left and right sides of the volunteers was 0.483g. There was no significant difference between the two groups (P < 0.05). Conclusion the concentration of GABA in striatum decreases with age, and the distribution of GABA in different sex is symmetrical.
【作者單位】： 廣西醫(yī)科大學第一附屬醫(yī)院放射科;青島大學醫(yī)學院附屬醫(yī)院放射科;
【基金】：國家自然科學基金項目資助項目(81260215) 廣西區(qū)基金項目(2012GXNSFAA053142)
【分類號】：R445.2;R741

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