本文選題：磁共振成像 + Tρ��； 參考：《中國(guó)醫(yī)學(xué)影像技術(shù)》2015年04期

【摘要】：目的探討磁共振T1ρ成像檢測(cè)兔膝關(guān)節(jié)軟骨早期退變的可行性。方法將32只實(shí)驗(yàn)兔隨機(jī)分組;其中24只(實(shí)驗(yàn)組)隨機(jī)分為A~D組,每組6只,均予左側(cè)膝關(guān)節(jié)腔內(nèi)注射木瓜蛋白酶,建立關(guān)節(jié)軟骨早期退變的模型;余8只作為空白對(duì)照組(E組),隨機(jī)分為EA、EB、EC、ED亞組,每組2只,分別做為A、B、C、D組的空白對(duì)照。于末次注藥后1、2、3、4周分別對(duì)A~D組(對(duì)EA、EB、EC、ED亞組進(jìn)行同期對(duì)照成像)行雙膝常規(guī)T2W、3D-FS-SPGR和T1ρ掃描后處死并取雙膝關(guān)節(jié)股骨髁軟骨做組織學(xué)檢查。測(cè)量并分析兔股骨髁軟骨T1ρ值組內(nèi)及組間的差異,并與組織學(xué)結(jié)果對(duì)照。結(jié)果實(shí)驗(yàn)組處理側(cè)(左側(cè))股骨髁軟骨T1ρ值均明顯高于對(duì)照側(cè)(P0.05);實(shí)驗(yàn)組處理側(cè)股骨髁軟骨T1ρ值隨時(shí)間推移逐漸升高(P0.05);T1ρ偽彩圖顯示實(shí)驗(yàn)組處理側(cè)軟骨呈淺綠色向深綠色的漸進(jìn)性改變;組織學(xué)檢查顯示實(shí)驗(yàn)組處理側(cè)股骨髁軟骨發(fā)生早期退變,軟骨內(nèi)PG含量明顯下降。結(jié)論 T1ρ值能夠敏感地量化反映關(guān)節(jié)軟骨退變?cè)缙�、形態(tài)學(xué)改變之前的蛋白多糖變化。T1ρ成像可能為臨床檢測(cè)關(guān)節(jié)軟骨早期退變提供影像學(xué)依據(jù)。
[Abstract]:Objective to investigate the feasibility of detecting early degeneration of articular cartilage in rabbits with T 1 蟻 magnetic resonance imaging (MRI). Methods Thirty-two experimental rabbits were randomly divided into two groups: group A (n = 6), and group A (n = 6) were injected papain into the left knee joint to establish the model of early degeneration of articular cartilage. The remaining 8 rats were randomly divided into two groups as a blank control group, two in each group. At 1: 2 and 3 ~ 4 weeks after the last injection, two knee routine T2WN 3D-FS-SPGR and T1 蟻 scans were performed respectively in Agna D group (EAA EBE ECE Ed subgroup), and the cartilage of femur condyle of both knee joints were taken for histological examination. The T 1 蟻 value of femoral condylar cartilage in rabbits was measured and analyzed, and the results were compared with histological results. Results the T1 蟻 value of femoral condylar cartilage in the experimental group (left side) was significantly higher than that in the control group (P 0.05), and the T1 蟻 value of the femoral condylar cartilage in the experimental group gradually increased with the passage of time. Gradual change of green; Histological examination showed that the early degeneration of femoral condylar cartilage and the decrease of PG content were observed in the experimental group. Conclusion T1 蟻 value can reflect the early degeneration of articular cartilage sensitively. The proteoglycan changes before morphologic changes. T1 蟻 imaging may provide the imaging basis for clinical detection of early degeneration of articular cartilage.
【作者單位】： 暨南大學(xué)附屬第一醫(yī)院疼痛門(mén)診;暨南大學(xué)附屬第一醫(yī)院影像中心;
【基金】：暨南大學(xué)科研培育與創(chuàng)新基金青年基金(21612304)
【分類號(hào)】：R445.2;R684

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本文編號(hào)：1936790