發(fā)布時(shí)間：2018-05-22 09:03

  本文選題：股骨頭壞死 + 脂肪含量��； 參考：《放射學(xué)實(shí)踐》2017年12期

【摘要】：目的:利用磁共振IDEAL-IQ和IVIM-DWI定量分析技術(shù),評(píng)估單髖激素性股骨頭壞死患者正常側(cè)股骨頭的脂肪含量及局部微循環(huán)狀況及其臨床意義。方法:將30例經(jīng)臨床首次確診的單髖激素性股骨頭壞死初治患者及16例性別和年齡相匹配的健康志愿者(對(duì)照組)納入研究,所有患者行X線及MRI檢查(包括常規(guī)序列、IDEAL-IQ及IVIMDWI),經(jīng)圖像后處理,獲得股骨頭脂肪含量(FF)及灌注分?jǐn)?shù)(f)值。對(duì)各定量參數(shù)值在壞死側(cè)、對(duì)側(cè)及對(duì)照組之間的差異進(jìn)行統(tǒng)計(jì)學(xué)分析,并采用ROC曲線評(píng)估其診斷效能。結(jié)果:對(duì)照組的FF值小于對(duì)側(cè)組及壞死組,差異均有統(tǒng)計(jì)學(xué)意義(P0.01)。壞死組的f值小于對(duì)側(cè)正常組及對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.01)。FF值的ROC曲線下面積為0.974,相應(yīng)的敏感度和特異度分別為96.9%和86.7%(P0.01)。f值的診斷效能無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:單髖激素性股骨頭壞死患者的對(duì)側(cè)股骨頭在常規(guī)MRI上無(wú)異常形態(tài)學(xué)改變,但I(xiàn)DEAL-IQ及IVIM-DWI定量分析技術(shù)卻能顯示其內(nèi)的脂肪含量和微循環(huán)狀況已發(fā)生改變,為股骨頭壞死的超早期診斷提供可能。
[Abstract]:Objective: to evaluate the fat content and local microcirculation of femoral head in patients with single hip steroid-induced femoral head necrosis by IDEAL-IQ and IVIM-DWI quantitative analysis. Methods: a total of 30 patients with steroid-induced osteonecrosis of the femoral head and 16 healthy volunteers (control group) with sex and age matching were included in the study. All the patients were examined by X-ray and MRI (including routine sequence IDEAL-IQ and IVIMDWIX). After image processing, the FFFs and perfusion fraction of femoral head were obtained. The difference of the quantitative parameters between the necrotic side, the contralateral side and the control group was analyzed statistically, and the diagnostic efficacy was evaluated by ROC curve. Results: the FF value of the control group was lower than that of the contralateral group and the necrotic group, and the difference was statistically significant (P 0.01). The f value of the necrotic group was lower than that of the contralateral normal group and the control group. The area under the ROC curve of the difference between the two groups was 0.974, the sensitivity and specificity were 96.9% and the diagnostic efficacy of 86.7%(P0.01).f was not statistically significant. Conclusion: the contralateral femoral head in patients with single hip steroid-induced femoral head necrosis has no abnormal morphological changes on conventional MRI. However, quantitative analysis of IDEAL-IQ and IVIM-DWI can show that the fat content and microcirculation in the femoral head have changed. It provides the possibility for ultrearly diagnosis of femoral head necrosis.
【作者單位】： 廣州市第一人民醫(yī)院華南理工大學(xué)附屬第二醫(yī)院;廣州中醫(yī)藥大學(xué);廣東藥科大學(xué)附屬第一醫(yī)院;廣州中醫(yī)藥大學(xué)第一附屬醫(yī)院;
【基金】：廣東省科技計(jì)劃項(xiàng)目(項(xiàng)目編號(hào):2014A020212594) 國(guó)家自然科學(xué)基金(8167150729) 廣東省杰出青年科學(xué)基金(2015A030306037)
【分類號(hào)】：R445.2;R681.8

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