本文選題：靜息態(tài) + 功能磁共振成像�。� 參考：《河北醫(yī)科大學》2017年碩士論文

【摘要】：目的:運用靜息態(tài)功能磁共振成像(Resting-state functional magneti c resonance imaging,rs-fMRI)技術,采用基于體素的靜息態(tài)功能連接(F unctional connectivity,FC)分析方法,研究中老年人和年輕人小腦各亞區(qū)之間功能連接模式,從而闡明小腦各亞區(qū)的功能連接模式是否存在年齡差異,以探討正常腦老化對小腦功能連接的影響,了解小腦是否存腦認知功能及正常腦老化對小腦功能的影響。材料與方法:選擇符合標準的正常志愿者共121人,均為右利手,分為兩組:年輕組60人(男23人,女37人,年齡范圍22-31歲,平均年齡26.15±1.9歲);中老年組61人(男23人,女38人,年齡范圍45-65歲,平均年齡52.6±5.9歲)。采用GE公司Signa Excite 3.0T超導型磁共振對所有被試者行靜息態(tài)fMRI掃描。應用基于MATLAB平臺的DPARSFA、SPM8及REST軟件進行預處理、功能連接計算及統(tǒng)計分析。預處理過程包括時間校正、頭動校正、空間標準化、空間平滑、去線性漂移、去除協(xié)變量和低頻濾波。在AAL模板中小腦共包含26個亞區(qū),將其作為感興趣區(qū)(ROI)分別進行功能連接分析,得到功能連接圖。統(tǒng)計分析采用兩樣本T檢驗,觀察中老年人和年輕人靜息態(tài)狀態(tài)下的功能連接模是否存在差異(P0.01),經(jīng)過alphasim校正(rmm=5)。將經(jīng)過兩樣本T檢驗的功能連接圖分別疊加到Ch2bet結構模板進行顯示,應用REST軟件觀察有統(tǒng)計學意義的激活團塊大小、包含腦區(qū)、MNI峰值坐標、團塊大小,并觀察其T值。結果:1中老年人組與年輕人組比較功能連接減弱的腦區(qū):1.1小腦蚓部1、2區(qū)(ROI1)中老年組較年輕組功能連接減弱的腦區(qū):雙側中央前回、雙側中央后回、雙側楔葉、雙側顳上回、雙側舌回、雙側枕中回、雙側枕下回、左側枕上回、左側梭狀回、右側島葉;1.2小腦蚓部3區(qū)(ROI2)中老年組較年輕組功能連接減弱的區(qū)域有:雙側枕中回、右側枕下回、左側舌回;1.3小腦蚓部4、5區(qū)(ROI3)中老年組較年輕組功能連接減弱的腦區(qū):雙側中央后回、右側中央前回、左側眶部額上回、左側內(nèi)側額上回、左側背外側額上回、右側背外側額上回;1.4小腦蚓部6區(qū)(ROI4)中老年組較年輕組功能連接減弱的腦區(qū):右側背外側額上回、左側顳下回、左側直回、左側楔前葉;1.5小腦蚓部7區(qū)(ROI5)中老年組較年輕組功能連接減弱的腦區(qū):右側中央后回、雙側內(nèi)側額上回、雙側眶部額中回;1.6小腦蚓部8區(qū)(ROI6)中老年組較年輕組功能連接減弱的腦區(qū):雙側中央后回、雙側矩狀裂周圍部分皮質、雙側眶部額中回、右側島蓋部額下回、右側顳下回、右側梭狀回、左側枕下回;1.7小腦蚓部9區(qū)(R0I7)中老年組較年輕組功能連接減弱的腦區(qū):雙側中央后回、雙側中央前回、雙側矩狀裂周圍皮質、左側直回、左側舌回、左側梭狀回、右側顳中回;1.8小腦蚓部10區(qū)(R0I8)中老年組較年輕組功能連接減弱的腦區(qū):雙側中央后回、右側中央前回、雙側枕上回、雙側枕下回、雙側眶部額上回、雙側梭狀回、右側顳下回、右側顳中回;1.9左側小腦3區(qū)(ROI9)中老年組較年輕組功能連接減弱的腦區(qū):雙側中央前回、雙側中央后回、雙側枕上回、雙側枕中回、雙側枕下回、雙側楔葉、雙側梭狀回、雙側顳中回、右側顳下回、右側額中回、左側額上回、左側額中回、左側舌回、左側頂下緣角回;1.10右側小腦3區(qū)(ROI10)中老年組較年輕組功能連接減弱的腦區(qū):雙側中央前回、雙側中央后回、雙側舌回、雙側楔葉、雙側顳中回、雙側顳下回、雙側梭狀回、雙側枕上回、雙側枕中回、雙側枕下回、雙側島葉、右側內(nèi)側額上回、中腦左側、右側補充活動區(qū);1.11左側小腦4、5 區(qū)(ROI11)中老年組較年輕組功能連接減弱的腦區(qū):右側中央前回、右側中央后回、右側島蓋下額下回、右側內(nèi)側額上回、右側海馬、左側島葉、左側顳上回;1.12右側小腦4、5區(qū)(ROI12)中老年組較年輕組功能連接減弱的腦區(qū):雙側角回、左側額中回、右側內(nèi)側額上回、右側眶部額下回;1.13左側小腦6區(qū)(ROI13)中老年組較年輕組功能連接減弱的腦區(qū):左側顳上回顳極、雙側島葉、右側海馬、右側額上回、右側丘腦、右側扣帶回前部;1.14右側小腦6區(qū)(ROI14)中老年組較年輕組功能連接減弱的腦區(qū):雙側海馬、左側海馬旁回、左側楔葉、左側中央前回、左側中央后回、左側島蓋部額下回、左側三角部額下回、右側顳中回、右側中央后回;1.15左側小腦7b區(qū)(R0I15)中老年組較年輕組功能連接減弱的腦區(qū):胼胝體、雙側扣帶回前部、雙側梭狀回、雙側海馬旁回、左側直回、左側眶部額下回、右側內(nèi)側額上回、右側眶部額中回;1.16右側小腦7b區(qū)(R0I16)中老年組較年輕組功能連接減弱的腦區(qū):左側海馬旁回、左側梭狀回、左側顳上回顳極、左側顳中回顳極、右側內(nèi)側額上回、胼胝體;1.17左側小腦8區(qū)(R0I17)中老年組較年輕組功能連接減弱的腦區(qū):腦干、雙側梭狀回、雙側矩狀裂周圍皮質、右側島葉、左側眶部額上回;1.18右側小腦8區(qū)(ROI18)中老年組較年輕組功能連接減弱的腦區(qū):腦干、延髓、左側丘腦、左側豆狀核、胼胝體、右側島葉、右側枕中回、左側中央鉤蓋;1.19左側小腦9區(qū)(R0I19)中老年組較年輕組功能連接減弱的腦區(qū):右側海馬旁回、右側枕中回;1.20右側小腦9區(qū)(ROI20)中老年組較年輕組功能連接減弱的腦區(qū):雙側內(nèi)側額上回、右側顳上回、左側矩狀裂周圍部分皮質;1.21左側小腦10區(qū)(ROI21)中老年組較年輕組功能連接減弱的腦區(qū):右側中央后回、右側眶部額上回、右側顳橫回、右側中央溝蓋、左側直回、雙側島葉;1.22右側小腦10區(qū)(ROI22)中老年組較年輕組功能連接減弱的腦區(qū):雙側中央后回、右側中央前回、雙側島葉、左側顳上回、右側梭狀回、左側舌回、右側楔葉、右側枕上回、右側枕中回、右側枕下回、右側矩狀裂周圍部分皮質、左側枕上回、左側丘腦、左側殼核;1.23左側小腦腳1區(qū)(ROI23)中老年組較年輕組功能連接減弱的腦區(qū):雙側中央前回、雙側中央后回、腦干偏左側、左側丘腦、雙側顳上回、左側外側額上回、左側島葉、右側額中回、雙側扣帶回中部、雙側補充活動區(qū);1.24右側小腦腳1區(qū)(ROI24)中老年組較年輕組功能連接減弱的腦區(qū):腦干偏左側、左側丘腦、雙側豆狀核、殼核、雙側中央后回、右側中央溝蓋、雙側扣帶回中部;1.25左側小腦腳2區(qū)(ROI25)中老年組較年輕組功能連接減弱的腦區(qū):左側額中回、右側海馬旁回、右側梭狀回、腦干、左側丘腦;1.26右側小腦腳2區(qū)(ROI26)中老年組較年輕組功能連接減弱的腦區(qū):左側顳上回、右側舌回、右側海馬旁回。2中老年人組與年輕人組比較,小腦各亞區(qū)與大腦功能連接增強的腦區(qū)主要分布在額中回、額下回、顳中回、顳下回、頂下緣角回、緣上回及角回。結論:1在靜息態(tài)下,中老年人組與年輕人比較小腦功能連接減弱的腦區(qū)范圍較廣泛,幾乎涉所有靜息態(tài)網(wǎng)絡,而不是僅僅位于感覺運動網(wǎng)絡;2中老年人組與年輕人組比較小腦功能連接減弱的腦區(qū)部分屬于"大腦-小腦"回路;3正常腦老化對左、右側小腦半球功能連接影響具有不對稱性;4中老年人組與年輕人組比較存在小腦與大腦功能連接增強腦區(qū),可能是對功能連接減弱相關腦區(qū)功能補償?shù)慕Y果。
[Abstract]:Objective: To study the functions of the cerebellar subregions by using the resting state function magnetic resonance imaging (Resting-state functional magneti c resonance imaging, rs-fMRI) and the resting state function connection based on the voxel (F unctional connectivity, FC) method to study the functional connection patterns between the middle and the aged and the young cerebellum subregions. The effect of normal brain aging on cerebellar functional connection and the effect of brain cognitive function on cerebellum and the effect of normal aging on cerebellum function. Materials and methods: 121 normal volunteers were selected as right hand and were divided into two groups: 60 young men (23 men and 37 women). The age range of 22-31 years, the average age of 26.15 + 1.9 years, 61 people in the middle and old age group (23 men, 38 women, age 45-65, average age 52.6 + 5.9 years old). GE company Signa Excite 3.0T superconducting magnetic resonance (MRI) for all subjects resting state fMRI scan. MATLAB platform based DPARSFA, SPM8 and REST software for preprocessing, functional connectivity The preprocessing process includes time correction, head motion correction, space standardization, spatial smoothing, de linear drift, removal of covariance and low-frequency filtering. In the AAL template, the small brain consists of 26 sub regions, and the functional connection analysis is carried out as a region of interest (ROI), and a functional connection diagram is obtained. Statistical analysis uses two samples. T test was used to observe the difference between the resting state of the elderly and the young people in the resting state (P0.01), and the alphasim correction (rmm=5). The functional connection charts after two samples T test were superimposed to the Ch2bet structure template, and the REST software was used to observe the significant size of the activated mass, including the brain area, MNI peak. Value coordinates, mass size, and observe its T value. Results: 1 the elderly group and the young group compared the functional connection of the brain area: 1.1 the aged group (ROI1) in the 1.1 cerebellar vermis (ROI1) is more than the younger group's functional connection in the brain area: bilateral central anterior gyrus, bilateral central posterior gyrus, bilateral cuneate lobe, bilateral superior temporal gyrus, bilateral lingual gyrus, bilateral occipital gyrus, bilateral occipital Gyrus, left occipital gyrus, left fusiform gyrus, right Island leaf; 1.2 middle aged group (ROI2) in the 3 area of cerebellar vermis: bilateral occipital gyrus, right occipital gyrus, left lingual gyrus, and 1.3 cerebellar vermis 4,5 zone (ROI3) in older group than younger group: bilateral central posterior gyrus, right anterior central gyrus, left side The upper frontal gyrus of the orbit, the upper lateral frontal gyrus, the upper lateral frontal and lateral frontal gyrus, the right dorsal lateral frontal gyrus, and the 1.4 middle aged group (ROI4) in the 6 cerebellar vermis were compared with the younger group's functional connectivity: the right dorsolateral upper lateral frontal gyrus, left temporal gyrus, left left direct gyrus, and left anterior wedge lobe, and 1.5 cerebellar vermis (ROI5) in the middle aged group of 1.5 cerebellar vermis. The weak brain area: right posterior central gyrus, bilateral medial frontal gyrus, bilateral orbital frontal gyrus, and bilateral orbital frontal gyrus; 1.6 middle aged group (ROI6) in the 8 cerebellar vermis, compared with the younger group, the functional connection weakened in the brain: bilateral central posterior gyrus, bilateral partial cortex, bilateral orbital frontal gyrus, right inferior frontal gyrus, right inferior temporal gyrus, right fusiform gyrus, left occipital left 1.7 in the 9 region of the cerebellar vermis (R0I7) in the middle and old age group, the functional connection of the young group was less than that of the younger group: bilateral central posterior gyrus, bilateral central anterior gyrus, bilateral medial cortex, left straight gyrus, left lingual gyrus, left fusiform gyrus, right middle temporal gyrus, and 1.8 cerebellar vermis (R0I8) in the older group than the younger group. Back, right anterior central gyrus, bilateral occipital gyrus, bilateral occipital gyrus, bilateral orbital frontal gyrus, bilateral orbital frontal gyrus, bilateral spindle gyrus, right inferior temporal gyrus, right temporal gyrus, 1.9 left cerebellum 3 region (ROI9) older group than young group's functional connection weakened brain area: bilateral central anterior gyrus, bilateral central posterior gyrus, bilateral occipital gyrus, bilateral occipital gyrus, bilateral and inferior occipcipital gyrus, bilateral Cun Leaf, bilateral spindle gyrus, bilateral temporal gyrus, right temporal gyrus, right frontal gyrus, left superior frontal gyrus, left frontal gyrus, left lateral frontal gyrus, left lingual gyrus, and left apical angle gyrus; 1.10 right cerebellum 3 region (ROI10) aged group were compared with young group's functional connection weakened brain area: bilateral central anterior gyrus, bilateral central posterior gyrus, bilateral lingual gyrus, bilateral cuneate lobe, bilateral cuneate lobe, bilateral temporal gyrus Lateral temporal gyrus, bilateral spindle gyrus, bilateral occipital gyrus, bilateral occipital gyrus, bilateral occipital gyrus, bilateral occipital gyrus, bilateral insula, right medial frontal gyrus, left side of the middle brain, right supplementation area; 1.11 left cerebellar 4,5 area (ROI11) middle aged group compared with the younger group, the functional connection weakened in the brain area: right lateral central anterior gyrus, right posterior central gyrus, right Island inferior frontal and inferior gyrus, right island under the right side The medial frontal gyrus, right hippocampal, left insula, left temporal gyrus, 1.12 right cerebellar 4,5 area (ROI12) middle aged group were compared with the younger group's functional connectivity: bilateral angular gyrus, left middle frontal gyrus, right medial upper frontal gyrus, right orbital inferior frontal gyrus, and 1.13 left cerebellum 6 areas (ROI13) middle aged group compared with the younger group functional connection weakened brain area: left left brain area: left left brain area: left left brain area: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side: left side The upper temporal and temporal pole, bilateral Island, right hippocampus, right frontal gyrus, right frontal gyrus, right thalamus, right cingulate gyrus, and 1.14 right cerebellum 6 regions (ROI14) were compared with the younger group's functional connection in the brain: bilateral hippocampus, left parahippocampal gyrus, left cuneate lobe, left central anterior gyrus, left central posterior gyrus, left islid inferior frontal gyrus, left triangle frontal The lower right temporal gyrus, right posterior central posterior gyrus, 1.15 left cerebellar 7b area (R0I15) in the elderly group were compared with the younger group, the corpus callosum, bilateral cingulate gyrus, bilateral fusiform gyrus, bilateral parahippocampal gyrus, left side straight gyrus, left orbital frontal gyrus, right medial frontal gyrus, right orbital frontal gyrus, and right cerebellar 7b zone (R0I16), 1.16 In the older group, the functional connection weakened in the younger group: the left parahippocampal gyrus, the left fusiform gyrus, the left temporal gyrus and the temporal pole, the left temporal and temporal pole, the right medial frontal gyrus, the corpus callosum; the 1.17 middle aged group of the left cerebellum (R0I17) were compared with the younger group, the brain stem, the bilateral spindle gyrus, the bilateral fissure peri cortex, the right island. Leaves, left orbital frontal gyrus, 1.18 right cerebellum 8 region (ROI18) older group than the younger group functional connection weakened brain area: brain stem, medulla, left thalamus, left lenticular nucleus, corpus callosum, right Isle lobe, right occipital gyrus, left central hook lid, 1.19 left cerebellum 9 region (R0I19) older group than the younger group functional connection weakened brain area: right hippocampus hippocampus Paraplastic gyrus, right occipital gyrus, 1.20 right cerebellum 9 area (ROI20) older group than young group functional connection weakened brain area: bilateral medial upper frontal gyrus, right superior temporal gyrus, left moment split peripheral cortex; 1.21 left cerebellum 10 region (ROI21) middle aged group than young group function connected brain area: right posterior central gyrus, right orbital upper frontal gyrus, right Lateral temporal transverse gyrus, right central sulcus cover, left straight gyrus, bilateral insula, and 1.22 right cerebellum 10 areas (ROI22) in the middle and old age group compared with the younger group, the functional connection weakened in the brain: bilateral central posterior gyrus, right anterior central gyrus, bilateral insula, left lateral temporal gyrus, right fusiform gyrus, left lingual gyrus, right cuneate, right occipital gyrus, right occipital gyrus, right and right occipcipcipital gyrus, right The peripheral part cortex, left superior occipital gyrus, left thalamus, left putamen, 1.23 left cerebellar foot 1 (ROI23) middle aged group were compared with the younger group's functional connected brain area: bilateral central anterior gyrus, bilateral central posterior gyrus, left side of brain stem, left thalamus, bilateral superior temporal gyrus, left lateral frontal gyrus, left lateral insula, right middle frontal gyrus, bilateral buckle. 1.24 right cerebellar foot 1 areas (ROI24) in the right cerebellar foot 1 (ROI24) group had less functional connectivity than the younger group: the left side of the brain stem, the left thalamus, the bilateral lenticular nucleus, the putamen, the bilateral central posterior gyrus, the right central sulcus cover, the bilateral cingulate gyrus, and the 1.25 left cerebellar foot 2 (ROI25) middle aged group than the younger group. The weak brain area: left middle frontal gyrus, right parahippocampal gyrus, right fusiform gyrus, brain stem, left thalamus, 1.26 right cerebellar foot 2 (ROI26) middle aged group compared with young group functional connection weakened brain area: left temporal gyrus, right tongue gyrus, right hippocampal gyrus.2 middle aged group compared with young group, cerebellar subregions and brain functional connections were enhanced The brain region mainly distributed in the middle frontal gyrus, the lower frontal gyrus, the middle temporal gyrus, the inferior temporal gyrus, the inferior Cape gyrus, the upper margin and the angular gyrus. Conclusion: 1 in the resting state, the cerebellar functional connection of the middle-aged and the elderly compared with the young people is more extensive, almost all the resting networks, not only the sensory network; the elderly group and the young are younger than the young. The part of the brain region that the cerebellar functional connection is weaker than the cerebellar part belongs to the "cerebro cerebellum" loop, and the 3 normal brain aging has an asymmetric effect on the left and right cerebellar hemispheric functional connections; 4 in the middle and old age group, the cerebellar and brain functional connections are found to enhance the brain area, and can be compensatory for functional connection to decrease the function of the brain area. Result.

【學位授予單位】：河北醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R445.2

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