本文選題：小肝癌 + 肝臟加速容積采集技術(shù)�。� 參考：《寧夏醫(yī)科大學(xué)》2014年碩士論文

【摘要】：目的探討3.0T MR肝臟加速容積采集技術(shù)聯(lián)合DWI對(duì)肝硬化背景上小肝癌檢出與定性的價(jià)值。方法收集經(jīng)病理、DSA介入證實(shí)的107例肝硬化背景上的小肝癌患者的影像資料。共發(fā)現(xiàn)病灶119個(gè)，單發(fā)病灶95個(gè)，兩個(gè)病灶的12例，所有小肝癌患者均行T1WI（正、反相位），T2WI，多期動(dòng)態(tài)增強(qiáng)掃描（LAVA序列），，DWI掃描（b值800s/mm2）。比較并分析T1WI、T2WI、DWI、 LAVA增強(qiáng)各期及LAVA增強(qiáng)聯(lián)合DWI與LAVA增強(qiáng)對(duì)小肝癌的檢出率；T1WI（正、反相位）、T2WI、LAVA增強(qiáng)（Ａ組），T1WI（正、反相位）、T2WI、DWI（Ｂ組），二者聯(lián)合（Ｃ組）在小肝癌定性方面的價(jià)值。觀察各序列上小肝癌的信號(hào)特點(diǎn)，比較并分析各序列對(duì)小肝癌包膜的顯示，繪制病灶及周?chē)谓M織的時(shí)間信號(hào)強(qiáng)度曲線(xiàn)，測(cè)量小肝癌及其周?chē)谓M織ADC值。結(jié)果1、LAVA增強(qiáng)檢出小肝癌較DWI，T2WI，T1WI高，但LAVA增強(qiáng)與DWI比較無(wú)統(tǒng)計(jì)學(xué)差異。2、LAVA動(dòng)脈期檢出小肝癌較門(mén)脈期或平衡期高，且具有統(tǒng)計(jì)學(xué)差異。3、LAVA增強(qiáng)顯示小肝癌包膜（數(shù)量及完整性）多于于T1WI、T2WI，其中T1WI又多于T2WI。4、LAVA增強(qiáng)聯(lián)合DWI較單獨(dú)使用LAVA增強(qiáng)檢出微小肝癌高，但兩者之間無(wú)明顯統(tǒng)計(jì)學(xué)差異。5、C組準(zhǔn)確定性小肝癌較A組、B組高，且具有統(tǒng)計(jì)學(xué)差異。6、小肝癌ADC值低于周?chē)谓M織，二者之間比較具有統(tǒng)計(jì)學(xué)差異。結(jié)論1、LAVA增強(qiáng)較DWI、T2WI、T1WI可以較好的檢出小肝癌。2、LAVA多期增強(qiáng)動(dòng)脈期對(duì)肝硬化背景上小肝癌的檢出非常重要。3、LAVA增強(qiáng)（門(mén)脈期+平衡期）顯示小肝癌的包膜（數(shù)量、完整性）優(yōu)于T1WI、T2WI，其中T1WI優(yōu)于T2WI。4、LAVA增強(qiáng)聯(lián)合DWI可以減少對(duì)微小肝癌的漏診，DWI是LAVA增強(qiáng)有益的補(bǔ)充。5、LAVA增強(qiáng)聯(lián)合DWI有利于提高肝硬化背景上小肝癌的定性。6、本研究小肝癌ADC值低于周?chē)谓M織，說(shuō)明小肝癌彌散受限。
[Abstract]:Objective to investigate the value of 3.0T Mr liver accelerated volume acquisition combined with DWI in the detection and characterization of small hepatocellular carcinoma (HCC) in the background of liver cirrhosis. Methods the imaging data of 107 patients with small liver cancer confirmed by DSA were collected. A total of 119 lesions, 95 single lesions and 12 cases of two lesions were found. All patients with small liver cancer were treated with T1WI (positive, inverse phase T2WI). To compare and analyze the positive rate of T1WI, T2WII DWI, LAVA enhancement combined with DWI and LAVA enhancement in small hepatocellular carcinoma (SHCC) and the value of T1WI (positive, reverse phase T2WILVA enhanced group A) T1WI (positive, negative phase T2WIDWIIB group) in the qualitative aspect of small hepatocellular carcinoma (SHCC). The signal characteristics of small hepatocellular carcinoma (HCC) on each sequence were observed and compared and analyzed. The time signal intensity curves of focus and surrounding liver tissue were plotted and the ADC values of small liver cancer and its surrounding liver tissue were measured. Results (1) the detection of small hepatocellular carcinoma was higher than that of DWI T2WIT T1WI, but there was no significant difference between LAVA enhancement and DWI. 2 the small HCC detected in arterial phase was higher than that in portal phase or equilibrium phase. The number and integrity of the capsule of small hepatocellular carcinoma was more than that of T1WIV T2WI, and T1WI was higher than that of T2WI.4Laiva combined with DWI, compared with that of LAVA alone. But there was no statistical difference between the two groups. The accurate characterization of small hepatocellular carcinoma in group C was higher than that in group A and B, and there was a statistical difference. The ADC value of small liver cancer was lower than that of surrounding liver tissue, and there was a statistical difference between the two groups. Conclusion (1) compared with DWI-T2WII-T _ 1WI, LAVA can be used to detect small hepatocellular carcinoma (SHC) in arterial phase. It is very important to detect SHCC in the background of cirrhosis. 3% LAVA enhancement (balance phase of portal vein) shows the number of small hepatocellular carcinoma (SHCC). T1WI is better than T2WI.4L LAVA combined with DWI can reduce the missed diagnosis of small hepatocellular carcinoma. It is a useful supplement of LAVA enhancement. 5% LAVA enhancement combined with DWI is helpful to improve the quality of small liver cancer in liver cirrhosis background. This study is to study small hepatocellular carcinoma. The ADC value was lower than that in the surrounding liver tissue. This indicates that the diffusion of small hepatocellular carcinoma is limited.
【學(xué)位授予單位】：寧夏醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R735.7;R445.2

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 倪明立;王玉慧;湯艷萍;李永;王成偉;;DWI結(jié)合LAVA技術(shù)在肝臟占位性病變中的應(yīng)用價(jià)值[J];放射學(xué)實(shí)踐;2010年12期

2 張海彬;胡道予;張娟;李建軍;曾祥芹;;磁共振多b值DWI對(duì)肝臟局灶性占位性病變的應(yīng)用價(jià)值[J];放射學(xué)實(shí)踐;2011年09期

3 卞讀軍;肖恩華;;磁共振擴(kuò)散成像技術(shù)及其在肝癌的臨床應(yīng)用[J];國(guó)際醫(yī)學(xué)放射學(xué)雜志;2011年05期

4 李迎春;宋彬;陳加源;印隆林;;3.0T薄層動(dòng)態(tài)增強(qiáng)MRI與多層螺旋CT對(duì)肝細(xì)胞性肝癌的診斷價(jià)值[J];四川大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2010年03期

5 王彥民;姜慧杰;韓桂萍;李金平;張金玲;趙德利;王金娥;;64排CT增強(qiáng)在肝癌邊緣強(qiáng)化特征與病理表現(xiàn)相關(guān)性分析[J];哈爾濱醫(yī)科大學(xué)學(xué)報(bào);2010年04期

6 孟卓;許乙凱;張雅萍;何卓凱;賈飛鴿;;3.0T MR肝臟三維容積超快速多期動(dòng)態(tài)增強(qiáng)掃描在肝局灶性病變?cè)\斷中的價(jià)值[J];中國(guó)臨床醫(yī)學(xué)影像雜志;2008年06期

7 張成佳;何仕誠(chéng);滕皋軍;方文;郭金和;鄧鋼;朱光宇;李國(guó)昭;;TACE治療原發(fā)性肝癌對(duì)肝功能影響的相關(guān)因素分析[J];東南大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2013年01期

8 張潔;趙天佐;趙琴利;宮媛媛;劉磊;張賀誠(chéng);周桂娟;康慶;陳云翔;;肝硬化相關(guān)小肝癌的血供特點(diǎn)和MRI表現(xiàn)[J];中國(guó)中西醫(yī)結(jié)合影像學(xué)雜志;2013年01期

9 張學(xué)琴;陸健;王霄英;繆小芬;張濤;梁宏偉;黃愛(ài)娜;丁丁;姜吉鋒;方艷;楊雪飛;;多排螺旋CT與MRI對(duì)乙肝肝硬化背景小肝癌檢出的比較研究[J];臨床放射學(xué)雜志;2013年06期

10 徐麗娜;唐桂波;;磁共振LAVA技術(shù)結(jié)合DWI在肝臟常見(jiàn)病變?cè)\斷中的研究進(jìn)展[J];青海醫(yī)藥雜志;2011年10期

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