本文選題：速度向量成像技術(shù) + 動脈粥樣硬化��； 參考：《南京醫(yī)科大學(xué)》2014年碩士論文

【摘要】：研究目的 1)應(yīng)用VVI技術(shù)研究糖尿病組和正常對照組頸動脈斑塊長軸力學(xué)特征； 2)比較兩組之間各個(gè)感興趣區(qū)力學(xué)指標(biāo)的差異; 3)比較兩組內(nèi)各個(gè)感興趣區(qū)力學(xué)指標(biāo)的差異,指出哪些指標(biāo)可用于提示斑塊的 受力情況。 研究方法 選取2型糖尿病患者合并頸動脈斑塊50例,頸動脈斑塊不伴2型糖尿病患者50例作為對照組,應(yīng)用速度向量成像技術(shù)比較兩組間及兩組內(nèi)各點(diǎn)速度、應(yīng)變力和應(yīng)變率三個(gè)指標(biāo)間的差異。采用SPSS16.0統(tǒng)計(jì)軟件進(jìn)行分析,計(jì)量資料以均數(shù)加減標(biāo)準(zhǔn)差表示,結(jié)果均以P0.05為有顯著性意義。兩組間斑塊同一位置ROI同一參數(shù)比較應(yīng)用兩樣本獨(dú)立t檢驗(yàn),兩組內(nèi)斑塊不同ROI各參數(shù)比較應(yīng)用單因素方差分析,本組符合Levene方差齊性檢驗(yàn)并采用LSD檢驗(yàn)方法進(jìn)行多重比較。 研究結(jié)果 一、兩組一般情況比較 糖尿病組的年齡、性別、TC、TG、HDL、LDL與對照組比較無統(tǒng)計(jì)學(xué)意義(P0.05),糖尿病組空腹血糖較對照組明顯增高,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。 二、兩組間斑塊VVI各指標(biāo)間的比較糖尿病組的速度、應(yīng)變力及應(yīng)變率等各項(xiàng)指標(biāo)均較對照組減小(見表1)； 三、兩組內(nèi)斑塊不同ROI間各VVI指標(biāo)間的比較 3.1速度 3.1.1糖尿病組內(nèi)斑塊速度均是先從R1到R4減小,再從R4到R5增大；其中R1點(diǎn)速度正向峰值、負(fù)向峰值及峰值差值與R3、R4、R5相對應(yīng)指標(biāo)比較有統(tǒng)計(jì)學(xué)意義(P0.05)； 3.1.2對照組速度正向峰值、負(fù)向峰值、峰值差值變化趨勢是先減小再增大,且各ROI間速度比較沒有統(tǒng)計(jì)學(xué)意義(P0.05)； 3.2應(yīng)變力 3.2.1糖尿病組內(nèi)斑塊應(yīng)變力正向峰值、負(fù)向峰值、峰值差值從R1到R2增大,R2到R4減小,再從R4到R5增大,其中R2點(diǎn)應(yīng)變力正向峰值與R1、R3、R4、R5相對應(yīng)指標(biāo)比較有統(tǒng)計(jì)學(xué)意義(P0.01,表2)； 3.2.2對照組應(yīng)變力正向峰值、負(fù)向峰值、峰值差值沒有明顯有規(guī)律的變化趨勢； 3.3應(yīng)變率 3.3.1糖尿病組內(nèi)斑塊應(yīng)變率各指標(biāo)變化趨勢與應(yīng)變表現(xiàn)相似,其中R2點(diǎn)應(yīng)變率正向峰值與R4點(diǎn)比較有統(tǒng)計(jì)學(xué)意義(P0.05,表3)； 3.3.2對照組內(nèi)斑塊應(yīng)變率正向峰值、負(fù)向峰值、峰值差值無明顯有規(guī)律的變話趨勢。 研究結(jié)論 1、通過VVI技術(shù)發(fā)現(xiàn)糖尿病組頸動脈斑塊各指標(biāo)較正常對照組減低,表明糖尿病組頸動脈斑塊整體機(jī)械性能下降； 2、通過組內(nèi)各指標(biāo)的分析比較得出頸動脈斑塊近心端肩部較其他各點(diǎn)受力更大,即更易破裂； 3、VVI技術(shù)可以在一定程度上評價(jià)T2DM患者頸動脈斑塊長軸上力學(xué)特征。
[Abstract]:Research purpose 1) VVI technique was used to study the long axis mechanical characteristics of carotid plaque in diabetic group and normal control group. 2) to compare the difference of mechanical indexes between the two groups in each region of interest; 3) to compare the differences of mechanical indexes between the two groups in different regions of interest, and to point out which indexes can be used to indicate the number of plaques. Stress. Research method Fifty patients with type 2 diabetes mellitus complicated with carotid artery plaque and 50 patients with carotid plaque without type 2 diabetes mellitus were selected as control group. Velocity vector imaging was used to compare the velocities of each point between two groups and within two groups. The difference between the three indexes of strain and strain rate. The statistical software of SPSS16.0 was used to analyze, and the measurement data were expressed as the standard deviation of mean addition and subtraction, and the results were all significant in the form of P0.05. Single factor analysis of variance (ANOVA) was used to compare the same ROI parameters of plaque at the same location between the two groups and the plaque ROI parameters in the two groups. The homogeneity test of Levene variance and the LSD test method were used to carry out multiple comparisons between the two groups. Research results One, two groups of general comparison There was no significant difference in age, sex, age and sex between the two groups (P 0.05). The fasting blood glucose in the diabetic group was significantly higher than that in the control group (P 0.05). Comparison of plaque VVI between the two groups; the velocity, strain and strain rate of diabetic group were lower than those of the control group (see Table 1). Comparison of different VVI Indexes between plaque and different ROI in two groups 3.1 Speed 3.1.1 plaque velocities in diabetic group were decreased from R1 to R4, then increased from R4 to R5, where the positive peak, negative peak value and difference between R1 and R4 R5 were significantly higher than those in R3 / R4 / R5 group (P < 0. 05). 3.1.2 in the control group, the change trend of the positive and negative peak velocity and the difference value of the peak value was to decrease first and then to increase, and there was no significant difference between the ROI and each other (P 0.05). 3.2 strain 3.2.1 the positive peak and negative peak of plaque strain in diabetes mellitus group, the difference of peak value increased from R1 to R2 to decrease from R2 to R4, and then increased from R4 to R5, in which the positive peak value of R2 point was significantly higher than that of R1 / R3 / R4 / R5 (P < 0.01). 3.2.2 in the control group, the positive peak value, negative peak value and the difference value of the peak value did not have a regular change trend. 3.3 strain rate 3.3.1 the variation trend of plaque strain rate in diabetic group was similar to that of strain, and the positive peak value of R2 point strain rate was significantly higher than that of R4 point (P 0.05). 3.3.2 in the control group, the positive peak value, negative peak value and difference value of plaque strain rate had no obvious tendency to change words regularly. Research conclusion 1. The results of VVI showed that the indexes of carotid plaques in diabetic group were lower than those in normal control group, which indicated that the mechanical properties of carotid plaques in diabetic group were lower than those in normal control group. 2, through the analysis and comparison of the indexes in the group, it was concluded that the proximal shoulder of carotid plaque was more forced than other points, that is, it was easier to rupture; VVI technique can be used to evaluate the long axis mechanical characteristics of carotid plaques in patients with T2DM.
【學(xué)位授予單位】：南京醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R445.2

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