發(fā)布時間：2018-04-13 17:01

  本文選題：認知障礙 + 磁共振成像　； 參考：《中國臨床醫(yī)學影像雜志》2017年08期

【摘要】：目的 :對比分析多b值彌散加權(quán)成像(MB-DWI)與動脈自旋標記(ASL)在評價輕度認知功能障礙(MCI)患者海馬灌注異常中的臨床應用價值。方法:依據(jù)診斷標準與排除標準,選擇MCI患者(MCI組)和認知功能正常的老年人(NC組)各20例,進行常規(guī)MRI平掃、MRA、ASL以及MB-DWI掃描,根據(jù)ASL-CBF圖測量雙側(cè)海馬最大rCBF_(ASL)值,并測量相應區(qū)域MBDWI與灌注相關(guān)參數(shù)fast ADC-mono、fraction of fast ADC-mono、fast ADC-bi、fraction of fast ADC-bi值,對MCI組和NC組分別進行相應參數(shù)的組間統(tǒng)計學差異分析和Pearson相關(guān)性分析。結(jié)果:MCI組雙側(cè)海馬rCBF_(ASL)值較NC組降低(P0.05);MCI組雙側(cè)海馬fast ADC-mono、fraction of fast ADC-mono、fraction of fast ADC-bi值與NC組的比較差異有統(tǒng)計學意義(P0.05),雙側(cè)海馬fast ADC-bi值較NC組減低,差異無統(tǒng)計學意義(P0.05);除fast ADC-bi值外,MCI組fast ADC-mono、fraction of fast ADC-mono、fraction of fast ADC-bi值與r CBFASL的相關(guān)性具有統(tǒng)計學意義(P0.05)。結(jié)論:MB-DWI和ASL在檢出MCI患者海馬的灌注改變方面具有一致性,可用于評估MCI患者灌注改變,有利于指導臨床。
[Abstract]:Objective: to compare and analyze the clinical value of MB-DWI and ASL in evaluating hippocampal perfusion abnormalities in patients with mild cognitive impairment (MCI).Methods: according to the diagnostic criteria and exclusion criteria, 20 MCI patients with MCI) and 20 elderly patients with normal cognitive function (NC group) were examined by conventional MRI plain scan and MB-DWI scanning. The maximum rCBFStax ASL value of bilateral hippocampus was measured according to ASL-CBF images.The corresponding regional MBDWI and perfusion related parameters fast ADC-monofraction of fast ADC-Monodo fast ADC-ADC-Monodo fractionof fast ADC-bi were measured. The statistical difference analysis and Pearson correlation analysis of the corresponding parameters between MCI group and NC group were carried out.Results compared with NC group, the value of fast ADC-bi in bilateral hippocampus of MCI group was significantly lower than that in NC group (P 0.05), and the value of fast ADC-bi in bilateral hippocampus was lower than that in NC group (P 0.05).There was no significant difference (P 0.05), except for fast ADC-bi, the correlation between the value of fast ADC-monochrome fractionation of fast ADC-monotaxa fractionation of fast ADC-bi and r CBFASL was statistically significant (P 0.05).ConclusionTwo MB-DWI and ASL are consistent in detecting the changes of hippocampal perfusion in patients with MCI, which can be used to evaluate the changes of perfusion in MCI patients and to guide clinical practice.
【作者單位】： 泰山醫(yī)學院;山東大學附屬千佛山醫(yī)院影像科;
【基金】：山東省科技發(fā)展計劃項目(2009GG10002024) 山東省醫(yī)藥衛(wèi)生科技發(fā)展計劃項目(2009HW075)
【分類號】：R445.2;R749.1

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