本文選題：急性腦梗死 + 動脈自旋標記�。� 參考：《廣西醫(yī)科大學》2017年碩士論文

【摘要】：目的:對比分析磁共振動脈自旋標記(arterial spin labeling,ASL)與動態(tài)磁敏感對比增強灌注成像(dynamic susceptibility contrast perfusion weighted imaging,DSC-PWI)在急性腦梗死中的應用價值。方法:對發(fā)病時間在72小時內(nèi)的30例急性腦梗死患者,采用T1WI、T2WI、DWI、FLAIR、擴散加權(quán)成像(DWI)、MRA、ASL及DSC-PWI檢查,對比觀察ASL與DSC的在急性腦梗死中的灌注表現(xiàn),采用對稱性檢(Bowker檢驗)分析DSC-PWI各參數(shù)分別與ASL-CBF的相關性。結(jié)果:30例行磁共振檢查的急性腦梗死患者,ASL灌注結(jié)果顯示低灌注24例,正常灌注3例,高灌注3例;DSC灌注結(jié)果顯示低灌注23例,正常灌注5例,高灌注2例;ASL與DSC低灌注結(jié)果一致23例,高灌注結(jié)果一致2例,正常灌注結(jié)果一致3例,低灌注結(jié)果一致率為76.6%。ASL灌注結(jié)果與DSC-PWI中CBF、CBV相比,具有統(tǒng)計學差異(P0.05),ASL與DSC-PWI中MTT、TTP相比,無明顯統(tǒng)計學差異(P0.05),與MTT、TTP的加權(quán)Kappa值分別為0.569、0.633,ASL與DSC-TTP具有較好一致性。結(jié)論:在急性腦梗死診斷中,ASL技術(shù)灌注結(jié)果與DSC技術(shù)相比有較好一致性,具有無創(chuàng)性且對低灌注的檢測敏感性較高。
[Abstract]:Objective: to compare and analyze the value of dynamic susceptibility contrast perfusion weighted imaging (DSC-PWI) with magnetic resonance arteriolar spin labeling (ASL) and dynamic magnetic sensitivity contrast enhanced perfusion imaging (DSC-PWI) in acute cerebral infarction.Methods: 30 patients with acute cerebral infarction within 72 hours were examined with T1WII T2WIT2WIFLAIR.DWIIMA MRAASL and DSC-PWI were examined by diffusion weighted imaging. The perfusion manifestations of ASL and DSC in acute cerebral infarction were compared and observed.The correlation between the parameters of DSC-PWI and ASL-CBF was analyzed by using the symmetry Bowker test.Results the results of ASL perfusion in 30 cases of acute cerebral infarction showed that 24 cases had low perfusion, 3 cases had normal perfusion, 3 cases had high perfusion, 23 cases had low perfusion and 5 cases had normal perfusion.The results of hyperperfusion were consistent with those of DSC in 23 cases, hyperperfusion in 2 cases and normal perfusion in 3 cases. The results of low perfusion were as follows: compared with DSC-PWI in DSC-PWI, there was statistical difference between 76.6%.ASL and DSC-PWI.There was no significant statistical difference (P 0.05). The weighted Kappa values of TTP and MTT were 0. 569 and 0. 633A, respectively. There was a good agreement between ASL and DSC-TTP.Conclusion: in the diagnosis of acute cerebral infarction, the perfusion results of ASL technique are consistent with those of DSC technique, and they are noninvasive and sensitive to low perfusion.
【學位授予單位】：廣西醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R445.2;R743.33

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