本文選題：正常 + 人靜　； 參考：《揚(yáng)州大學(xué)》2014年碩士論文

【摘要】：第一部分正常人中腦紅核與黑質(zhì)靜息狀態(tài)功能網(wǎng)絡(luò)連接研究 目的運(yùn)用靜息態(tài)功能磁共振成像(resting-state fMRI)技術(shù),分析感興趣區(qū)與全腦其它腦區(qū)間的功能連接,探討正常人在靜息狀態(tài)下,中腦的紅核及黑質(zhì)的功能連接網(wǎng)絡(luò)。 方法正常健康受試者20人,招募自揚(yáng)州大學(xué)醫(yī)學(xué)院及揚(yáng)州市城區(qū),受試者接受靜息狀態(tài)下fMRI掃描和磁敏感成像,提取fMRI數(shù)據(jù)的低頻波動(dòng)信號(hào),以紅核和黑質(zhì)作為種子區(qū),通過時(shí)程相關(guān)分析方法獲取紅核和黑質(zhì)的網(wǎng)絡(luò)結(jié)構(gòu)。使用Rest軟件包進(jìn)行組水平單樣本t檢驗(yàn),閾值設(shè)為經(jīng)Alphasim校正的p0.001,激活像素范圍42。 結(jié)果紅核的功能連接網(wǎng)絡(luò)構(gòu)成腦區(qū)包含：前扣帶回背側(cè)、緣上回、丘腦腹內(nèi)、腹外側(cè)核、蒼白球、背側(cè)丘腦、海馬頭部、黑質(zhì)、腦橋、小腦齒狀核；黑質(zhì)的功能連接網(wǎng)絡(luò)構(gòu)成腦區(qū)包含：緣上回、輔助運(yùn)動(dòng)區(qū)、蒼白球、海馬、島葉、紅核、腦橋、小腦齒狀核；左右兩側(cè)紅核、黑質(zhì)網(wǎng)絡(luò)構(gòu)造分別呈左右基本對(duì)稱分布。紅核與黑質(zhì)的功能網(wǎng)絡(luò)盡管大部重疊,但是還是存在一定的差別,紅核呈現(xiàn)了與紋狀體及丘腦更廣泛的功能連接。 結(jié)論中腦紅核、黑質(zhì)的功能網(wǎng)絡(luò)結(jié)構(gòu)主要表現(xiàn)為與錐體外系核團(tuán)間的緊密聯(lián)系,與其生理功能是一致的；除了與皮層下結(jié)構(gòu)有廣泛的功能連接,紅核、黑質(zhì)還與少數(shù)大腦皮層的腦區(qū)呈現(xiàn)功能協(xié)同；我們的研究表明磁共振功能連接成像是探索錐體外系功能圖譜的潛在的有力工具。 第二部分正常人靜息狀態(tài)下小腦齒狀核的功能網(wǎng)絡(luò)連接研究 目的運(yùn)用靜息態(tài)功能磁共振成像(resting-state fMRI)技術(shù),分析感興趣區(qū)與全腦其它腦區(qū)間的功能連接,探討正常人在靜息狀態(tài)下,小腦齒狀核的功能連接網(wǎng)絡(luò)。 方法正常健康受試者20人,招募自揚(yáng)州大學(xué)醫(yī)學(xué)院及揚(yáng)州市城區(qū),受試者接受靜息狀態(tài)fMRI掃描和磁敏感成像,通過時(shí)程相關(guān)分析方法檢測(cè)fMRI數(shù)據(jù)的低頻波動(dòng)信號(hào),獲取以小腦左右側(cè)齒狀核作為種子區(qū)的網(wǎng)絡(luò)結(jié)構(gòu),使用Rest軟件包進(jìn)行組水平單樣本t檢驗(yàn),閾值設(shè)為經(jīng)Alphasim校正的p0.001,激活像素范圍42。 結(jié)果左側(cè)齒狀核的功能連接網(wǎng)絡(luò)構(gòu)成腦區(qū)主要包含：兩側(cè)小腦半球、小腦扁桃體、小腦蚓部、對(duì)側(cè)齒狀核、腦橋、中腦(紅核、黑質(zhì))、背側(cè)丘腦、豆?fàn)詈�、蒼白球、屏狀核、島葉；右側(cè)齒狀核的功能連接網(wǎng)絡(luò)構(gòu)成腦區(qū)主要包含：兩側(cè)小腦半球、小腦扁桃體、對(duì)側(cè)齒狀核、小腦蚓部、腦橋；左右兩側(cè)齒狀核網(wǎng)絡(luò)構(gòu)造分別呈左右基本對(duì)稱分布。 結(jié)論齒狀核的功能網(wǎng)絡(luò)構(gòu)造主要包含了小腦、腦干、丘腦及一些大腦皮層下核團(tuán),其功能網(wǎng)絡(luò)呈現(xiàn)了錐體外系結(jié)構(gòu)的緊密聯(lián)系,反映了功能網(wǎng)絡(luò)與解剖網(wǎng)絡(luò)的一致性。齒狀核的網(wǎng)絡(luò)分析可以反映錐體外系的功能連接情況。
[Abstract]:Part I study on the connections between the red nucleus of the midbrain and the resting state of the substantia nigra in normal subjectsObjective to analyze the functional connections between the region of interest and other brain regions of the whole brain using resting functional magnetic resonance imaging (fMRI) technique, and to explore the functional connections between the red nucleus and the substantia nigra of the midbrain in normal subjects.Methods Twenty healthy subjects were recruited from Yangzhou University School of Medicine and Yangzhou City. The subjects received fMRI scanning and magnetic sensitivity imaging under resting state, and extracted the low frequency wave signals from fMRI data. The red nucleus and substantia nigra were used as seed regions.The network structure of red nucleus and substantia nigra was obtained by time history correlation analysis.Rest software package was used to test the group level single sample, the threshold value was set to p0.001 corrected by Alphasim, and the active pixel range was 42.Results the functional connective network of the red nucleus consisted of the dorsal cingulate gyrus, superior marginal gyrus, ventral thalamus, ventrolateral nucleus, globus pallidus, dorsal thalamus, hippocampal head, substantia nigra, pons and dentate nucleus of cerebellum.The functional junction network of the substantia nigra consists of superior marginal gyrus, auxiliary motor area, globus pallidus, hippocampus, island lobe, red nucleus, pons and cerebellar dentate nucleus.Although most of the functional networks of the red nucleus and the substantia nigra overlap, there are some differences between the red nucleus and the striatum and thalamus.Conclusion the functional network structure of the mesencephalic red nucleus and substantia nigra is mainly related to the outer pyramidal nucleus and is consistent with its physiological function, except for the extensive functional connection with the subcortical structure.The substantia nigra is also present in synergy with a few areas of the cerebral cortex; our research suggests that magnetic resonance imaging is a potentially powerful tool for exploring the functional map of extrapyramidal systems.Part II functional network connections of the dentate nucleus of the cerebellum in normal subjects at restAim to analyze the functional connections between the region of interest and other brain regions of the whole brain using resting functional magnetic resonance imaging (fMRI) technique, and to explore the functional connectivity network of the dentate nucleus of the cerebellum in the rest state of normal persons.Methods Twenty healthy subjects were recruited from Yangzhou University School of Medicine and Yangzhou City. The subjects received resting fMRI scan and magnetic sensitivity imaging. The low frequency wave signals of fMRI data were detected by time-history correlation analysis.The network structure with the left and right dentate nucleus of cerebellum as seed region was obtained. The threshold value was set to p0.001 corrected by Alphasim and the activation pixel range was 42. 2 by using Rest software package to perform a single sample t-test at the level of group level.Results the functional connective network of the left dentate nucleus consisted of bilateral cerebellar hemisphere, cerebellar tonsil, cerebellar vermis, contralateral dentate nucleus, pons, midbrain (red nucleus, substantia nigra, dorsal thalamus, lenticular nucleus, globus pallidus, platelike nucleus).The functional connective network of the right dentate nucleus consists of the bilateral cerebellar hemisphere, the cerebellar tonsil, the contralateral dentate nucleus, the cerebellar vermis, and the pons.Conclusion the functional network of dentate nucleus mainly consists of cerebellum, brainstem, thalamus and some subcortical nuclei. Its functional network is closely related to the structure of extrapyramidal system, which reflects the consistency between functional network and anatomical network.The network analysis of dentate nucleus can reflect the functional connection of extrapyramidal system.
【學(xué)位授予單位】：揚(yáng)州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R445.2;R742

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