本文選題：乳腺腫瘤　切入點：擴散磁共振成像　出處：《中國醫(yī)學影像技術(shù)》2015年07期

【摘要】：目的應(yīng)用體素內(nèi)不相干運動(IVIM)雙指數(shù)模型探討真性彌散系數(shù)(D)、與灌注相關(guān)的假性彌散系數(shù)(D*),灌注分數(shù)(f)在診斷乳腺腫塊樣病變診斷中的應(yīng)用價值。方法收集經(jīng)病理證實的乳腺惡性腫塊48例(惡性組)、良性腫塊26例(良性組)及正常體檢者19名(對照組),均行常規(guī)MRI檢查及多b值的彌散加權(quán)成像檢查。比較3組間D值、f值、D*值及ADC值的差異,采用ROC曲線評估各個指標對乳腺良惡性腫塊樣病變的診斷效能。結(jié)果對照組、良性組及惡性組間D、f、D*及ADC值的差異均有統(tǒng)計學意義(P均0.01)。良性組D值低于對照組、且高于惡性組(P均0.01);惡性組f值高于對照組及良性組(P均0.01),而對照組與良性組間差異無統(tǒng)計學意義(P=0.14);良性組D*值低于對照組、高于惡性組(P均0.01);良性組ADC值低于對照組、高于惡性組(P均0.01)。惡性組的D值顯著低于ADC值(P0.01)。分析采用各DWI參數(shù)鑒別診斷乳腺惡性腫塊樣變的ROC曲線,D值具有較高的診斷效能,其次依次為ADC值,f值及D*值,曲線下面積(AUC)依次為0.95、0.90、0.87、0.75。結(jié)論 IVIM雙指數(shù)模型能夠真實反映乳腺腫塊樣病變水分子的彌散情況,尤其是D值對乳腺病變良惡性的鑒別診斷具有重要的參考意義。
[Abstract]:Objective to investigate the diagnostic value of true diffusion coefficient (DG), pseudo-diffusive coefficient (PSD) and perfusion fraction (F) in diagnosis of breast tumor-like lesions by using the IVIM-VIVIMM model. Methods the clinical data of dysmenorrhea were collected. 48 cases of malignant breast masses (malignant group, 26 cases of benign mass) and 19 cases of normal physical examination (control group) were examined by conventional MRI and diffusion-weighted imaging with multiple b values. The difference between the value of D * and the value of ADC, ROC curve was used to evaluate the diagnostic efficacy of each index for benign and malignant breast tumor-like lesions. Results there were significant differences in D * and ADC values among the control group, benign group and malignant group (P < 0.01). The D value of benign group was lower than that of control group. The F value of the malignant group was higher than that of the control group and the benign group, but there was no significant difference between the control group and the benign group, the D * value of the benign group was lower than that of the control group and higher than that of the malignant group, and the ADC value of the benign group was lower than that of the control group. The D value of malignant group was significantly lower than that of ADC value (P 0.01). The value of ROC curve D in differential diagnosis of malignant breast mass by DWI parameters was higher than that in malignant tumor group (P < 0.01), followed by ADC value F value and D * value, and the value of D value was higher than that of malignant tumor group (P < 0.01), and the D value of malignant group was significantly lower than that of ADC value (P < 0.01). The area under the curve is 0.950.90 / 0.870.75.Conclusion the IVIM double index model can truly reflect the diffusion of water molecules in breast tumor-like lesions, especially the D value is of great significance for the differential diagnosis of benign and malignant breast lesions.
【作者單位】： 南方醫(yī)科大學附屬深圳市婦幼保健院放射科;深圳市第二人民醫(yī)院介入治療科;北京大學深圳醫(yī)院醫(yī)學影像中心;
【分類號】：R445.2;R737.9

【參考文獻】

相關(guān)期刊論文 前1條

1 吳曉燕;張貴祥;;擴散加權(quán)成像在乳腺癌中的的臨床應(yīng)用進展[J];中國醫(yī)學影像技術(shù);2012年11期

【共引文獻】

相關(guān)期刊論文 前7條

1 汪飛;鮑克志;朱娟;楊擎;;MRM BI-RADS 3-5類腫塊性病變的DCE-MRI及DWI聯(lián)合應(yīng)用價值探討[J];中國臨床醫(yī)學影像雜志;2013年09期

2 梁玉玉;朱蓉蓉;哈若水;;比較雙指數(shù)與傳統(tǒng)單指數(shù)模型ADC值對浸潤性導管癌診斷效能研究[J];臨床放射學雜志;2014年08期

3 吳海龍;龔良庚;;磁共振功能成像在乳腺腫瘤的應(yīng)用進展[J];臨床放射學雜志;2014年10期

4 Koichi Hayano;Jorge M Fuentes-Orrego;Dushyant V Sahani;;New approaches for precise response evaluation in hepatocellular carcinoma[J];World Journal of Gastroenterology;2014年12期

5 趙金麗;李敏達;田浩;顧紅梅;沈海霞;吳獻華;;多模態(tài)磁共振成像技術(shù)在乳腺病變診斷中的應(yīng)用[J];中華臨床醫(yī)師雜志(電子版);2014年24期

6 柳善剛;任瑞美;;彌散加權(quán)成像在腫瘤療效監(jiān)測和評估中的應(yīng)用及進展[J];中華臨床醫(yī)師雜志(電子版);2015年02期

7 史卓;趙心明;楊成歡;;肝臟磁共振彌散加權(quán)成像技術(shù)的進展[J];中國腫瘤臨床與康復;2015年07期

相關(guān)碩士學位論文 前4條

1 李青;DCE-MRI及DWI與乳腺癌生物學預后因子的相關(guān)性研究[D];新疆醫(yī)科大學;2013年

2 侯煒寰;磁共振擴散加權(quán)成像對直腸癌分期分級的定量評估[D];第四軍醫(yī)大學;2014年

3 史卓;肝臟磁共振彌散加權(quán)成像三種呼吸采集方式的比較[D];北京協(xié)和醫(yī)學院;2014年

4 于學娟;3.0T-MRI表觀擴散系數(shù)與乳腺癌病理及分子生物學指標的相關(guān)性研究[D];濟南大學;2014年

【二級參考文獻】

相關(guān)期刊論文 前4條

1 A.D. Kingv;K.K. Chow;K.H. Yu;F.K.F. Mo;D.K.W. Yeung;J. Yuan;郭凌飛;;頭頸部鱗狀細胞癌:擴散加權(quán)MR成像對預測治療反應(yīng)的診斷性能[J];國際醫(yī)學放射學雜志;2013年02期

2 顧雅佳;馮曉源;唐峰;彭衛(wèi)軍;毛健;楊文濤;;乳腺腫瘤的MRI擴散特征及參數(shù)選定[J];中華放射學雜志;2007年05期

3 劉侃;周純武;歐陽漢;羅德紅;;3.0T MR擴散加權(quán)成像鑒別鼻咽癌患者頸部轉(zhuǎn)移淋巴結(jié)[J];中國醫(yī)學影像技術(shù);2010年03期

4 陳明;邢偉;陳杰;生晶;田建明;;擴散加權(quán)成像評價放射治療鼻咽癌伴頸部轉(zhuǎn)移性淋巴結(jié)療效[J];中國醫(yī)學影像技術(shù);2011年03期

，

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