本文選題：椎底動脈供血不足　切入點：磁共振波譜學　出處：《中國臨床醫(yī)學影像雜志》2015年05期

【摘要】：目的:應用磁共振波譜技術(MRS)探討椎基底動脈供血不足(VBI)患者的枕葉及小腦代謝物變化。方法:選取9例經臨床和MRA診斷為VBI患者和7名年齡相匹配的健康志愿者(對照組),采用化學位移成像采集枕葉及小腦的MRS數據,測量VBI患者及正常對照組的代謝物比值NAA/Cr、NAA/Cr2、Cho/Cr、Cho/Cr2、NAA/Cho,采用Mann-Whitney U檢驗比較兩組間MRS代謝參數之間的差異;并統(tǒng)計兩組間Lac峰出現的例數,應用Fisher確切概率法比較有無差異。結果 :VBI患者組枕葉的NAA/Cr、NAA/Cr2、Cho/Cr、Cho/Cr2、NAA/Cho與對照組差異無統(tǒng)計學意義(均P0.05);VBI患者組小腦的NAA/Cr低于對照組(0.83±0.15比0.98±0.14,P=0.043),NAA/Cr2、Cho/Cr、Cho/Cr2、NAA/Cho與對照組差異無統(tǒng)計學意義(均P0.05);9例VBI患者中4例在小腦可探測到Lac峰,1例在枕葉可探測到Lac峰,對照組均未探測到Lac峰,差別具有統(tǒng)計學意義(P=0.034)。結論:應用MRS技術可敏感的探測VBI患者腦組織代謝物的變化,有助于從生化角度評價VBI導致的腦損害。
[Abstract]:Objective: to investigate the changes of metabolites in occipital lobe and cerebellum in patients with vertebrobasilar insufficiency (VBI) by magnetic resonance spectroscopy (MRS). Methods: 9 patients with VBI diagnosed clinically and MRA and 7 age-matched healthy volunteers were selected. MRS data of occipital lobe and cerebellum were collected by chemical shift imaging. The metabolite ratios of VBI patients and normal controls were measured. The metabolic parameters of MRS were compared by Mann-Whitney U test, and the cases of Lac peak appeared in the two groups were counted, and the ratio of NAA / NAA / NAA / NAA / NAA / Cr _ (2) / Cr _ (2) / Cr _ (2) / Cr _ (2) / Cr _ (2) / Cr _ (2) O _ (2) were measured. Results there was no significant difference in NAA/Cr between the two groups by using the exact probability method of Fisher. Results there was no significant difference in NAA/Cr between the two groups (P 0.05). The NAA/Cr of the cerebellum in the patients with VBI was 0.83 鹵0.15 vs 0.98 鹵0.14P 0.043. There was no significant difference between the two groups (all of them had no significant difference between the control group and the control group (P < 0.05). In 9 cases of VBI, 4 cases could detect Lac peak in cerebellum and 1 case could detect Lac peak in occipital lobe. No Lac peak was detected in the control group, and the difference was statistically significant. Conclusion: the application of MRS can sensitively detect the changes of brain metabolites in VBI patients, which is helpful to evaluate the brain damage caused by VBI from a biochemical point of view.
【作者單位】： 濱州醫(yī)學院煙臺附屬醫(yī)院放射科;
【分類號】：R743;R445.2

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