本文選題：椎底動(dòng)脈供血不足　切入點(diǎn)：磁共振波譜學(xué)　出處：《中國(guó)臨床醫(yī)學(xué)影像雜志》2015年05期

【摘要】：目的:應(yīng)用磁共振波譜技術(shù)(MRS)探討椎基底動(dòng)脈供血不足(VBI)患者的枕葉及小腦代謝物變化。方法:選取9例經(jīng)臨床和MRA診斷為VBI患者和7名年齡相匹配的健康志愿者(對(duì)照組),采用化學(xué)位移成像采集枕葉及小腦的MRS數(shù)據(jù),測(cè)量VBI患者及正常對(duì)照組的代謝物比值NAA/Cr、NAA/Cr2、Cho/Cr、Cho/Cr2、NAA/Cho,采用Mann-Whitney U檢驗(yàn)比較兩組間MRS代謝參數(shù)之間的差異;并統(tǒng)計(jì)兩組間Lac峰出現(xiàn)的例數(shù),應(yīng)用Fisher確切概率法比較有無差異。結(jié)果 :VBI患者組枕葉的NAA/Cr、NAA/Cr2、Cho/Cr、Cho/Cr2、NAA/Cho與對(duì)照組差異無統(tǒng)計(jì)學(xué)意義(均P0.05);VBI患者組小腦的NAA/Cr低于對(duì)照組(0.83±0.15比0.98±0.14,P=0.043),NAA/Cr2、Cho/Cr、Cho/Cr2、NAA/Cho與對(duì)照組差異無統(tǒng)計(jì)學(xué)意義(均P0.05);9例VBI患者中4例在小腦可探測(cè)到Lac峰,1例在枕葉可探測(cè)到Lac峰,對(duì)照組均未探測(cè)到Lac峰,差別具有統(tǒng)計(jì)學(xué)意義(P=0.034)。結(jié)論:應(yīng)用MRS技術(shù)可敏感的探測(cè)VBI患者腦組織代謝物的變化,有助于從生化角度評(píng)價(jià)VBI導(dǎo)致的腦損害。
[Abstract]:Objective: to investigate the changes of metabolites in occipital lobe and cerebellum in patients with vertebrobasilar insufficiency (VBI) by magnetic resonance spectroscopy (MRS). Methods: 9 patients with VBI diagnosed clinically and MRA and 7 age-matched healthy volunteers were selected. MRS data of occipital lobe and cerebellum were collected by chemical shift imaging. The metabolite ratios of VBI patients and normal controls were measured. The metabolic parameters of MRS were compared by Mann-Whitney U test, and the cases of Lac peak appeared in the two groups were counted, and the ratio of NAA / NAA / NAA / NAA / NAA / Cr _ (2) / Cr _ (2) / Cr _ (2) / Cr _ (2) / Cr _ (2) / Cr _ (2) O _ (2) were measured. Results there was no significant difference in NAA/Cr between the two groups by using the exact probability method of Fisher. Results there was no significant difference in NAA/Cr between the two groups (P 0.05). The NAA/Cr of the cerebellum in the patients with VBI was 0.83 鹵0.15 vs 0.98 鹵0.14P 0.043. There was no significant difference between the two groups (all of them had no significant difference between the control group and the control group (P < 0.05). In 9 cases of VBI, 4 cases could detect Lac peak in cerebellum and 1 case could detect Lac peak in occipital lobe. No Lac peak was detected in the control group, and the difference was statistically significant. Conclusion: the application of MRS can sensitively detect the changes of brain metabolites in VBI patients, which is helpful to evaluate the brain damage caused by VBI from a biochemical point of view.
【作者單位】： 濱州醫(yī)學(xué)院煙臺(tái)附屬醫(yī)院放射科;
【分類號(hào)】：R743;R445.2

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