本文選題：膠質(zhì)瘤　切入點：分級　出處：《山西醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:調(diào)查動態(tài)對比增強磁共振檢查所獲得的定量參數(shù)區(qū)別低級別膠質(zhì)瘤和高級別膠質(zhì)瘤的能力。方法:以“膠質(zhì)瘤”、“星形細胞瘤”、“神經(jīng)上皮性腫瘤”、“動態(tài)對比增強”、“DCE”、“dynamic contrast enhanced”“glioma”“astrocytoma”“astrocytic tumour”“neuroepithelial neoplasms”“neuroepithelial tumour”為關(guān)鍵詞,在中國知網(wǎng)(CNKI)、萬方數(shù)據(jù)庫、維普數(shù)據(jù)庫、PubMed、Science Direct、Cochrane Library中檢索國內(nèi)外公開發(fā)表的有關(guān)動態(tài)對比增強對膠質(zhì)瘤分級診斷的文獻,使用Rev Man5.3軟件對文獻進行Meta分析。結(jié)果:一共檢索到317篇文獻,最終有10篇關(guān)于動態(tài)對增強磁共振檢查在膠質(zhì)瘤分級診斷中應(yīng)用的文獻納入分析,累計病例數(shù)為419例。Meta分析結(jié)果如下:(1)LGG腫瘤實質(zhì)區(qū)的Ktrans值低于HGG腫瘤實質(zhì)區(qū)的Ktrans值WMD=-0.14,95%CI[-0.16,-0.11],結(jié)果有統(tǒng)計學(xué)意義;(2)LGG腫瘤實質(zhì)區(qū)的Ve值低于HGG腫瘤實質(zhì)區(qū)的Ve值WMD=-0.21,95%CI[-0.29,-0.15],結(jié)果有統(tǒng)計學(xué)意義;(3)LGG腫瘤實質(zhì)區(qū)的Vp值低于HGG腫瘤實質(zhì)區(qū)的Vp值WMD=-0.03,95%CI[-0.07,-0.00],結(jié)果無統(tǒng)計學(xué)意義;(4)LGG腫瘤實質(zhì)區(qū)的Kep值低于HGG腫瘤實質(zhì)區(qū)的Kep值WMD=-0.36,95%CI[-1.06,0.35],結(jié)果無統(tǒng)計學(xué)意義。結(jié)論:(1)動態(tài)對比增強所獲得的定量參數(shù)Ktrans、Ve有助于確定膠質(zhì)瘤的級別,LGG腫瘤實質(zhì)區(qū)的Ktrans、Ve低于HGG腫瘤實質(zhì)區(qū)的Ktrans、Ve。(2)由于我們納入的各項研究間存在異質(zhì)性,某些研究質(zhì)量偏低,所以還需要進一步的高質(zhì)量大樣本的病例系列研究,從而對Ktrans、Ve、Vp、Kep在膠質(zhì)瘤分級中的應(yīng)用進行更為系統(tǒng)、全面、深入的評價。
[Abstract]:Objective: to investigate the ability of dynamic contrast-enhanced magnetic resonance imaging (Mr) to distinguish between low-grade gliomas and high-grade gliomas. Methods: by using "glioma", "astrocytoma", "neuroepithelial tumor", "dynamic contrast" Enhancement, "DCE," "dynamic contrast enhanced," "glioma," "astrocytoma," "astrocytic tumour," "neuroepithelial neoplasms," "neuroepithelial tumour," The literature published at home and abroad on dynamic contrast enhancement in the diagnosis of glioma grading was searched in CNKI, Wanfang database, Webb database and PubMedMed Science Direct Cochrane Library. Meta analysis was performed with Rev Man5.3 software. Results: a total of 317 papers were retrieved, and 10 papers were included in the analysis on the application of dynamic contrast-enhanced magnetic resonance imaging in the grading diagnosis of gliomas. The results of meta-analysis are as follows: the Ktrans value of the tumor parenchyma of 1: 1 / HGG is lower than that of the Ktrans of HGG [-0.16 + -0.11]. The results show that the value of ve in the tumor parenchyma is lower than that in the tumor of HGG [WMD-0.21995 CI [-0.29h-0.15]. The value of VP in the tumor parenchyma of HGG was lower than that in the parenchyma of HGG [-0.07 + -0.00]. The results showed that the Kep value of the tumor parenchyma of HGG was lower than the value of Kep of HGG. There was no statistical significance. Conclusion there is no statistical significance. The quantitative parameter KtransVe obtained is helpful to determine the grade of gliomas. The KtransVe of the GG tumor parenchyma is lower than that of the HGG. Because of the low quality of some studies, it is necessary to further study the case series of high quality and large sample, so as to evaluate the application of VpP Kep in glioma classification more systematically, comprehensively and thoroughly.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R445.2;R739.41

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