本文選題：納米金粒子　切入點(diǎn)：蒙特卡羅　出處：《強(qiáng)激光與粒子束》2017年12期 　論文類型：期刊論文

【摘要】：納米金粒子(GNP)應(yīng)用為放療輻射增敏劑是目前國(guó)際上的一個(gè)研究熱點(diǎn)。使用自主研發(fā)的納劑量生物物理蒙特卡羅程序(NASIC),模擬研究了光子照射下細(xì)胞環(huán)境中GNP的物理增敏效應(yīng)和生物增敏效應(yīng)。通過(guò)建立單個(gè)GNP位于細(xì)胞核中心以及多個(gè)GNP在細(xì)胞內(nèi)四種理想分布的GNP-細(xì)胞模型,分析光子能量、GNP粒子尺寸和分布對(duì)能量沉積、DNA輻射損傷和細(xì)胞存活的影響。結(jié)果表明,GNP附近約2μm的范圍內(nèi)具有能量沉積的增強(qiáng)效應(yīng),這主要是因?yàn)镚NP內(nèi)光電效應(yīng)作用數(shù)目的顯著增加。不同條件下細(xì)胞核內(nèi)能量沉積、DSB數(shù)目和細(xì)胞存活分?jǐn)?shù)增強(qiáng)效應(yīng)的變化規(guī)律基本一致,但增強(qiáng)因子呈遞減趨勢(shì),三種評(píng)價(jià)指標(biāo)增強(qiáng)因子的最大值分別為1.55,1.32和1.14。光子能量為40keV、GNP直徑為100nm并分布在細(xì)胞核表面時(shí),相比其他參數(shù)組合具有較高的物理和生物輻射增敏效應(yīng)。
[Abstract]:The application of nanocrystalline gold particle GNP as radiosensitizer is a hot topic in the world. The physics of GNP in cell environment under photon irradiation was simulated by using the self-developed nano-dose biophysical Monte Carlo program (NASCC). Through the establishment of a single GNP located in the nuclear center and four ideal distribution of GNP in the cell, we established the GNP-cell model. The effects of the size and distribution of photonic energy (GNP) particles on DNA radiation damage and cell survival in energy deposition were analyzed. The results showed that there was an enhanced effect of energy deposition in the range of about 2 渭 m near GNP. This is mainly due to the significant increase in the number of photovoltaic effects in GNP. The changes of the number of DSBs in the nucleus and the enhancement effect of cell survival fraction were basically consistent under different conditions, but the enhancement factors showed a decreasing trend. The maximum value of enhancement factor of the three evaluation indexes was 1.55g 1.32 and 1.14.The photon energy of 40keV GNP was 100nm and distributed on the nuclear surface, which had higher physical and biological radiosensitization effect than other parameter combinations.
【作者單位】： 清華大學(xué)工程物理系;清華大學(xué)粒子技術(shù)與輻射成像教育部重點(diǎn)實(shí)驗(yàn)室;同方威視技術(shù)股份有限公司;
【基金】：國(guó)家自然科學(xué)基金項(xiàng)目(11375103) 國(guó)家重點(diǎn)基礎(chǔ)研究計(jì)劃項(xiàng)目(2016YFC0904600)
【分類號(hào)】：R730.55
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本文編號(hào)：1650041